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Correlation between different intensities of anti-vitamin K treatment and coagulation parameters

Jerkeman, Anna LU ; Astermark, Jan LU ; Hedner, Ulla LU ; Lethagen, Stefan LU ; Olsson, Carl-Gustav and Berntorp, Erik LU (2000) In Thrombosis Research 98(6). p.467-471
Abstract
In order to study the effect of different intensities of anti-vitamin K treatment on coagulation parameters, 23 patients with venous thromboembolism were given, after the initial treatment period, warfarin at doses giving an International Normalised Ratio of 1.3-2.0 for 4 weeks, and of 1.1-1.3 for another 4 weeks. Blood samples were taken at the end of each of these periods and 4 weeks after the end of warfarin treatment. The vitamin K-dependent coagulation factors VII, IX, and X, as well as the inhibitor protein C and its cofactor protein S, all showed a highly significant correlation with treatment intensity. This was to some extent also true for the coagulation activation markers, prothrombin fragment 1+2 and thrombin-antithrombin... (More)
In order to study the effect of different intensities of anti-vitamin K treatment on coagulation parameters, 23 patients with venous thromboembolism were given, after the initial treatment period, warfarin at doses giving an International Normalised Ratio of 1.3-2.0 for 4 weeks, and of 1.1-1.3 for another 4 weeks. Blood samples were taken at the end of each of these periods and 4 weeks after the end of warfarin treatment. The vitamin K-dependent coagulation factors VII, IX, and X, as well as the inhibitor protein C and its cofactor protein S, all showed a highly significant correlation with treatment intensity. This was to some extent also true for the coagulation activation markers, prothrombin fragment 1+2 and thrombin-antithrombin complex. Ratios of pro- and anticoagulant factors in some instances showed a decrease at therapeutical (International Normalised Ratio) levels, and also sometimes with reduced warfarin treatment intensity. Taken together, our results encourage further research addressing issues of varying treatment intensity with warfarin and alternative methods for monitoring of anti-vitamin K treatment. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Thrombosis Research
volume
98
issue
6
pages
467 - 471
external identifiers
  • pmid:10899345
  • scopus:0034659271
ISSN
1879-2472
DOI
10.1016/S0049-3848(00)00203-6
language
English
LU publication?
yes
id
91c08436-9e24-40b9-9f1f-dcb69f270179 (old id 1117379)
date added to LUP
2008-06-27 14:41:27
date last changed
2017-01-01 04:45:17
@article{91c08436-9e24-40b9-9f1f-dcb69f270179,
  abstract     = {In order to study the effect of different intensities of anti-vitamin K treatment on coagulation parameters, 23 patients with venous thromboembolism were given, after the initial treatment period, warfarin at doses giving an International Normalised Ratio of 1.3-2.0 for 4 weeks, and of 1.1-1.3 for another 4 weeks. Blood samples were taken at the end of each of these periods and 4 weeks after the end of warfarin treatment. The vitamin K-dependent coagulation factors VII, IX, and X, as well as the inhibitor protein C and its cofactor protein S, all showed a highly significant correlation with treatment intensity. This was to some extent also true for the coagulation activation markers, prothrombin fragment 1+2 and thrombin-antithrombin complex. Ratios of pro- and anticoagulant factors in some instances showed a decrease at therapeutical (International Normalised Ratio) levels, and also sometimes with reduced warfarin treatment intensity. Taken together, our results encourage further research addressing issues of varying treatment intensity with warfarin and alternative methods for monitoring of anti-vitamin K treatment.},
  author       = {Jerkeman, Anna and Astermark, Jan and Hedner, Ulla and Lethagen, Stefan and Olsson, Carl-Gustav and Berntorp, Erik},
  issn         = {1879-2472},
  language     = {eng},
  number       = {6},
  pages        = {467--471},
  series       = {Thrombosis Research},
  title        = {Correlation between different intensities of anti-vitamin K treatment and coagulation parameters},
  url          = {http://dx.doi.org/10.1016/S0049-3848(00)00203-6},
  volume       = {98},
  year         = {2000},
}