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Malignancies during follow-up in an epidemiologically defined systemic lupus erythematosus inception cohort in southern Sweden

Nived, O LU ; Bengtsson, A LU ; Jönsen, A LU ; Sturfelt, G LU and Olsson, H LU (2001) In Lupus 10(7). p.4-500
Abstract

The objective of this study was to identify all malignancies in an inception cohort of SLE patients in southern Sweden and compare with the observed frequencies and spectrum of malignancies in the general population. All adult incidence cases of SLE in a defined population during the period 1981-1996 were retrieved from a prospective database and the cases were followed to endpoint or through 1998. The SLE cohort registry was aggregated with the National Cancer Registry to identify all malignancies by date, type and outcome. Standardized morbidity rates (SMR) were calculated based on the sex- and age-matched general population of the region. Sixteen malignancies occurred in 13 patients out of a total of 116 SLE patients observed for... (More)

The objective of this study was to identify all malignancies in an inception cohort of SLE patients in southern Sweden and compare with the observed frequencies and spectrum of malignancies in the general population. All adult incidence cases of SLE in a defined population during the period 1981-1996 were retrieved from a prospective database and the cases were followed to endpoint or through 1998. The SLE cohort registry was aggregated with the National Cancer Registry to identify all malignancies by date, type and outcome. Standardized morbidity rates (SMR) were calculated based on the sex- and age-matched general population of the region. Sixteen malignancies occurred in 13 patients out of a total of 116 SLE patients observed for 1086 patient-years. The SMR for all cancers detected was 2.24 (confidence interval 0.6-5.7) for males and 1.02 (confidence interval 0.4-2.1) for females and thus indicative of no general increase in malignancies. However, the SMR for non-Hodgkin lymphoma was 11.63 (confidence interval 1.4-42.0), for pulmonary cancer 5.55 (confidence interval 0.7-20.1) and prostatic cancer 6.41 (confidence interval 1.3-18.7) all significantly increased. The increase in prostatic carcinoma disappeared when only cases occurring after a latency period of 3y after SLE diagnosis were included. In this comprehensive inception cohort of SLE no increase in relative risk of malignancy overall was found, but the frequencies of non-Hodgkin lymphoma and pulmonary cancer were increased, possibly also the frequency of prostatic carcinoma.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Incidence, Lupus Erythematosus, Systemic, Male, Middle Aged, Neoplasms
in
Lupus
volume
10
issue
7
pages
5 pages
publisher
SAGE Publications Ltd
external identifiers
  • pmid:11480849
  • scopus:0034918755
ISSN
0961-2033
DOI
10.1191/096120301678416079
language
English
LU publication?
yes
id
2c1a77b5-89d0-4811-970a-5ebfaa744f13 (old id 1120130)
date added to LUP
2008-07-08 11:13:47
date last changed
2018-05-29 12:02:14
@article{2c1a77b5-89d0-4811-970a-5ebfaa744f13,
  abstract     = {<p>The objective of this study was to identify all malignancies in an inception cohort of SLE patients in southern Sweden and compare with the observed frequencies and spectrum of malignancies in the general population. All adult incidence cases of SLE in a defined population during the period 1981-1996 were retrieved from a prospective database and the cases were followed to endpoint or through 1998. The SLE cohort registry was aggregated with the National Cancer Registry to identify all malignancies by date, type and outcome. Standardized morbidity rates (SMR) were calculated based on the sex- and age-matched general population of the region. Sixteen malignancies occurred in 13 patients out of a total of 116 SLE patients observed for 1086 patient-years. The SMR for all cancers detected was 2.24 (confidence interval 0.6-5.7) for males and 1.02 (confidence interval 0.4-2.1) for females and thus indicative of no general increase in malignancies. However, the SMR for non-Hodgkin lymphoma was 11.63 (confidence interval 1.4-42.0), for pulmonary cancer 5.55 (confidence interval 0.7-20.1) and prostatic cancer 6.41 (confidence interval 1.3-18.7) all significantly increased. The increase in prostatic carcinoma disappeared when only cases occurring after a latency period of 3y after SLE diagnosis were included. In this comprehensive inception cohort of SLE no increase in relative risk of malignancy overall was found, but the frequencies of non-Hodgkin lymphoma and pulmonary cancer were increased, possibly also the frequency of prostatic carcinoma.</p>},
  author       = {Nived, O and Bengtsson, A and Jönsen, A and Sturfelt, G and Olsson, H},
  issn         = {0961-2033},
  keyword      = {Aged,Aged, 80 and over,Female,Follow-Up Studies,Humans,Incidence,Lupus Erythematosus, Systemic,Male,Middle Aged,Neoplasms},
  language     = {eng},
  number       = {7},
  pages        = {4--500},
  publisher    = {SAGE Publications Ltd},
  series       = {Lupus},
  title        = {Malignancies during follow-up in an epidemiologically defined systemic lupus erythematosus inception cohort in southern Sweden},
  url          = {http://dx.doi.org/10.1191/096120301678416079},
  volume       = {10},
  year         = {2001},
}