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Persistent high signal on diffusion-weighted MRI in the late stages of small cortical and lacunar ischaemic lesions

Geijer, Bo LU ; Lindgren, Arne LU ; Brockstedt, Sara LU ; Ståhlberg, Freddy LU and Holtås, Stig LU (2001) In Neuroradiology 43(2). p.115-122
Abstract
Diffusion-weighted imaging (DWI) is very sensitive to early brain infarcts. However, the late stages have been insufficiently studied. Infarcts in small vessel disease are often multiple and of different ages, and differentiation between new and old lesions might be difficult. We have therefore studied the change with time in DWI of small (< 3 ml) ischaemic lesions. We imaged 21 patients with an acute lacunar syndrome and a lesion visible on early DWI. They all had three MRI examinations 12-58 h (early), 7-16 and 54-144 days after the onset of stroke; 10 patients with high DWI signal on the third examination had a fourth examination 12-28 months after the stroke. MRI was performed at 1.5 T, using echo-planar DWI with 7 b-values from 0... (More)
Diffusion-weighted imaging (DWI) is very sensitive to early brain infarcts. However, the late stages have been insufficiently studied. Infarcts in small vessel disease are often multiple and of different ages, and differentiation between new and old lesions might be difficult. We have therefore studied the change with time in DWI of small (< 3 ml) ischaemic lesions. We imaged 21 patients with an acute lacunar syndrome and a lesion visible on early DWI. They all had three MRI examinations 12-58 h (early), 7-16 and 54-144 days after the onset of stroke; 10 patients with high DWI signal on the third examination had a fourth examination 12-28 months after the stroke. MRI was performed at 1.5 T, using echo-planar DWI with 7 b-values from 0 to 1200 x 10(6) s/m2 and conventional T2-weighted imaging. After 7-16 days 18 of 21 lesions gave high signal on DWI, and 12/16 measurable lesions had a decreased apparent diffusion coefficient (ADC). After 54-144 days ten lesions still gave high DWI signal and two still had an ADC below normal. On the fourth examination there was no remaining high DWI signal and all ADC were higher than normal. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Key words Brain, ischaemia, Magnetic resonance imaging, diffusion-weighted
in
Neuroradiology
volume
43
issue
2
pages
115 - 122
publisher
Springer Verlag
external identifiers
  • pmid:11326555
  • scopus:0035131211
ISSN
1432-1920
DOI
10.1007/s002340000489
language
English
LU publication?
yes
id
c9627768-d829-4be5-b722-07cf8aaeb3ce (old id 1121076)
date added to LUP
2008-06-27 14:14:51
date last changed
2018-05-29 11:16:25
@article{c9627768-d829-4be5-b722-07cf8aaeb3ce,
  abstract     = {Diffusion-weighted imaging (DWI) is very sensitive to early brain infarcts. However, the late stages have been insufficiently studied. Infarcts in small vessel disease are often multiple and of different ages, and differentiation between new and old lesions might be difficult. We have therefore studied the change with time in DWI of small (&lt; 3 ml) ischaemic lesions. We imaged 21 patients with an acute lacunar syndrome and a lesion visible on early DWI. They all had three MRI examinations 12-58 h (early), 7-16 and 54-144 days after the onset of stroke; 10 patients with high DWI signal on the third examination had a fourth examination 12-28 months after the stroke. MRI was performed at 1.5 T, using echo-planar DWI with 7 b-values from 0 to 1200 x 10(6) s/m2 and conventional T2-weighted imaging. After 7-16 days 18 of 21 lesions gave high signal on DWI, and 12/16 measurable lesions had a decreased apparent diffusion coefficient (ADC). After 54-144 days ten lesions still gave high DWI signal and two still had an ADC below normal. On the fourth examination there was no remaining high DWI signal and all ADC were higher than normal.},
  author       = {Geijer, Bo and Lindgren, Arne and Brockstedt, Sara and Ståhlberg, Freddy and Holtås, Stig},
  issn         = {1432-1920},
  keyword      = {Key words Brain,ischaemia,Magnetic resonance imaging,diffusion-weighted},
  language     = {eng},
  number       = {2},
  pages        = {115--122},
  publisher    = {Springer Verlag},
  series       = {Neuroradiology},
  title        = {Persistent high signal on diffusion-weighted MRI in the late stages of small cortical and lacunar ischaemic lesions},
  url          = {http://dx.doi.org/10.1007/s002340000489},
  volume       = {43},
  year         = {2001},
}