Markers of high fish intake are associated with decreased risk of a first myocardial infarction
(2001) In British Journal of Nutrition 86(3). p.397-404- Abstract
- High intake of fish has been associated with reduced risk of CHD. The high content of n-3 polyunsaturated fatty acids (PUFA) in fish has been suggested to be a protective factor. In addition, fish is the entirely dominating source of methylmercury for the general population, and the concentration of Hg in erythrocytes (Ery-Hg) is often used as an index of fish consumption. Our aim was to study the relationships between a first-ever myocardial infarction, Ery-Hg, activity of gluthathione peroxidase in erythrocytes (Ery-GSH-Px) and plasma concentration of the n-3 PUFA eicosapentaenoic and docosahexaenoic acids (P-PUFA). In a population-based prospective nested case-control study within Northern Sweden seventy-eight cases of a first-ever... (More)
- High intake of fish has been associated with reduced risk of CHD. The high content of n-3 polyunsaturated fatty acids (PUFA) in fish has been suggested to be a protective factor. In addition, fish is the entirely dominating source of methylmercury for the general population, and the concentration of Hg in erythrocytes (Ery-Hg) is often used as an index of fish consumption. Our aim was to study the relationships between a first-ever myocardial infarction, Ery-Hg, activity of gluthathione peroxidase in erythrocytes (Ery-GSH-Px) and plasma concentration of the n-3 PUFA eicosapentaenoic and docosahexaenoic acids (P-PUFA). In a population-based prospective nested case-control study within Northern Sweden seventy-eight cases of a first-ever myocardial infarction were compared with 156 controls with respect to Ery-Hg, P-PUFA and Ery-GSH-Px. Both Ery-Hg and P-PUFA, but not Ery-GSH-Px, were significantly higher in subjects reporting high fish intake (at least one meal per week) than in those with lower intake. This finding suggests that Ery-Hg and P-PUFA reflect previous long-term fish intake. Low risk of myocardial infarction was associated with high Ery-Hg or high P-PUFA. In a multivariate model the risk of myocardial infarction was further reduced in subjects with both high Ery-Hg and high P-PUFA (odds ratio 0.16, 95 % CI 0.04, 0.65). In conclusion, there is a strong inverse association between the risk of a first myocardial infarction and the biomarkers of fish intake, Ery-Hg and P-PUFA, and this association is independent of traditional risk factors. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1121696
- author
- Hallgren, C G ; Hallmans, G ; Jansson, J H ; Marklund, S L ; Huhtasaari, F ; Schutz, A ; Strömberg, Ulf LU ; Vessby, B and Skerfving, Staffan LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Fish intake, Mercury, n-3 polyunsaturated fatty acids, Myocardial infarction
- in
- British Journal of Nutrition
- volume
- 86
- issue
- 3
- pages
- 397 - 404
- publisher
- Cambridge University Press
- external identifiers
-
- pmid:11570992
- scopus:0034809498
- ISSN
- 1475-2662
- DOI
- 10.1079/BJN2001415
- language
- English
- LU publication?
- yes
- id
- e96c61e2-122a-47ba-b745-c412b31f0be1 (old id 1121696)
- date added to LUP
- 2016-04-01 11:59:31
- date last changed
- 2022-01-26 21:11:49
@article{e96c61e2-122a-47ba-b745-c412b31f0be1, abstract = {{High intake of fish has been associated with reduced risk of CHD. The high content of n-3 polyunsaturated fatty acids (PUFA) in fish has been suggested to be a protective factor. In addition, fish is the entirely dominating source of methylmercury for the general population, and the concentration of Hg in erythrocytes (Ery-Hg) is often used as an index of fish consumption. Our aim was to study the relationships between a first-ever myocardial infarction, Ery-Hg, activity of gluthathione peroxidase in erythrocytes (Ery-GSH-Px) and plasma concentration of the n-3 PUFA eicosapentaenoic and docosahexaenoic acids (P-PUFA). In a population-based prospective nested case-control study within Northern Sweden seventy-eight cases of a first-ever myocardial infarction were compared with 156 controls with respect to Ery-Hg, P-PUFA and Ery-GSH-Px. Both Ery-Hg and P-PUFA, but not Ery-GSH-Px, were significantly higher in subjects reporting high fish intake (at least one meal per week) than in those with lower intake. This finding suggests that Ery-Hg and P-PUFA reflect previous long-term fish intake. Low risk of myocardial infarction was associated with high Ery-Hg or high P-PUFA. In a multivariate model the risk of myocardial infarction was further reduced in subjects with both high Ery-Hg and high P-PUFA (odds ratio 0.16, 95 % CI 0.04, 0.65). In conclusion, there is a strong inverse association between the risk of a first myocardial infarction and the biomarkers of fish intake, Ery-Hg and P-PUFA, and this association is independent of traditional risk factors.}}, author = {{Hallgren, C G and Hallmans, G and Jansson, J H and Marklund, S L and Huhtasaari, F and Schutz, A and Strömberg, Ulf and Vessby, B and Skerfving, Staffan}}, issn = {{1475-2662}}, keywords = {{Fish intake; Mercury; n-3 polyunsaturated fatty acids; Myocardial infarction}}, language = {{eng}}, number = {{3}}, pages = {{397--404}}, publisher = {{Cambridge University Press}}, series = {{British Journal of Nutrition}}, title = {{Markers of high fish intake are associated with decreased risk of a first myocardial infarction}}, url = {{http://dx.doi.org/10.1079/BJN2001415}}, doi = {{10.1079/BJN2001415}}, volume = {{86}}, year = {{2001}}, }