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Markers of high fish intake are associated with decreased risk of a first myocardial infarction

Hallgren, C G; Hallmans, G; Jansson, J H; Marklund, S L; Huhtasaari, F; Schutz, A; Strömberg, Ulf LU ; Vessby, B and Skerfving, Staffan LU (2001) In British Journal of Nutrition 86(3). p.397-404
Abstract
High intake of fish has been associated with reduced risk of CHD. The high content of n-3 polyunsaturated fatty acids (PUFA) in fish has been suggested to be a protective factor. In addition, fish is the entirely dominating source of methylmercury for the general population, and the concentration of Hg in erythrocytes (Ery-Hg) is often used as an index of fish consumption. Our aim was to study the relationships between a first-ever myocardial infarction, Ery-Hg, activity of gluthathione peroxidase in erythrocytes (Ery-GSH-Px) and plasma concentration of the n-3 PUFA eicosapentaenoic and docosahexaenoic acids (P-PUFA). In a population-based prospective nested case-control study within Northern Sweden seventy-eight cases of a first-ever... (More)
High intake of fish has been associated with reduced risk of CHD. The high content of n-3 polyunsaturated fatty acids (PUFA) in fish has been suggested to be a protective factor. In addition, fish is the entirely dominating source of methylmercury for the general population, and the concentration of Hg in erythrocytes (Ery-Hg) is often used as an index of fish consumption. Our aim was to study the relationships between a first-ever myocardial infarction, Ery-Hg, activity of gluthathione peroxidase in erythrocytes (Ery-GSH-Px) and plasma concentration of the n-3 PUFA eicosapentaenoic and docosahexaenoic acids (P-PUFA). In a population-based prospective nested case-control study within Northern Sweden seventy-eight cases of a first-ever myocardial infarction were compared with 156 controls with respect to Ery-Hg, P-PUFA and Ery-GSH-Px. Both Ery-Hg and P-PUFA, but not Ery-GSH-Px, were significantly higher in subjects reporting high fish intake (at least one meal per week) than in those with lower intake. This finding suggests that Ery-Hg and P-PUFA reflect previous long-term fish intake. Low risk of myocardial infarction was associated with high Ery-Hg or high P-PUFA. In a multivariate model the risk of myocardial infarction was further reduced in subjects with both high Ery-Hg and high P-PUFA (odds ratio 0.16, 95 % CI 0.04, 0.65). In conclusion, there is a strong inverse association between the risk of a first myocardial infarction and the biomarkers of fish intake, Ery-Hg and P-PUFA, and this association is independent of traditional risk factors. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Fish intake, Mercury, n-3 polyunsaturated fatty acids, Myocardial infarction
in
British Journal of Nutrition
volume
86
issue
3
pages
397 - 404
publisher
Cambridge University Press
external identifiers
  • pmid:11570992
  • scopus:0034809498
ISSN
1475-2662
DOI
10.1079/BJN2001415
language
English
LU publication?
yes
id
e96c61e2-122a-47ba-b745-c412b31f0be1 (old id 1121696)
date added to LUP
2008-08-27 14:39:27
date last changed
2018-04-01 03:27:30
@article{e96c61e2-122a-47ba-b745-c412b31f0be1,
  abstract     = {High intake of fish has been associated with reduced risk of CHD. The high content of n-3 polyunsaturated fatty acids (PUFA) in fish has been suggested to be a protective factor. In addition, fish is the entirely dominating source of methylmercury for the general population, and the concentration of Hg in erythrocytes (Ery-Hg) is often used as an index of fish consumption. Our aim was to study the relationships between a first-ever myocardial infarction, Ery-Hg, activity of gluthathione peroxidase in erythrocytes (Ery-GSH-Px) and plasma concentration of the n-3 PUFA eicosapentaenoic and docosahexaenoic acids (P-PUFA). In a population-based prospective nested case-control study within Northern Sweden seventy-eight cases of a first-ever myocardial infarction were compared with 156 controls with respect to Ery-Hg, P-PUFA and Ery-GSH-Px. Both Ery-Hg and P-PUFA, but not Ery-GSH-Px, were significantly higher in subjects reporting high fish intake (at least one meal per week) than in those with lower intake. This finding suggests that Ery-Hg and P-PUFA reflect previous long-term fish intake. Low risk of myocardial infarction was associated with high Ery-Hg or high P-PUFA. In a multivariate model the risk of myocardial infarction was further reduced in subjects with both high Ery-Hg and high P-PUFA (odds ratio 0.16, 95 % CI 0.04, 0.65). In conclusion, there is a strong inverse association between the risk of a first myocardial infarction and the biomarkers of fish intake, Ery-Hg and P-PUFA, and this association is independent of traditional risk factors.},
  author       = {Hallgren, C G and Hallmans, G and Jansson, J H and Marklund, S L and Huhtasaari, F and Schutz, A and Strömberg, Ulf and Vessby, B and Skerfving, Staffan},
  issn         = {1475-2662},
  keyword      = {Fish intake,Mercury,n-3 polyunsaturated fatty acids,Myocardial infarction},
  language     = {eng},
  number       = {3},
  pages        = {397--404},
  publisher    = {Cambridge University Press},
  series       = {British Journal of Nutrition},
  title        = {Markers of high fish intake are associated with decreased risk of a first myocardial infarction},
  url          = {http://dx.doi.org/10.1079/BJN2001415},
  volume       = {86},
  year         = {2001},
}