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Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)

Scheja, Agneta LU ; Åkesson, Anita LU ; Geborek, Pierre LU ; Wildt, Marie LU ; Wollheim, Claes B ; Wollheim, Frank LU and Vischer, Ulrich M (2001) In Arthritis Research & Therapy 3(3). p.178-182
Abstract
In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups. Higher values of the propeptide were observed in patients with early pulmonary involvement. A closer correlation of the propeptide than of vWf to biochemical markers of activity was also evident. Our results suggest that the propeptide, despite a shorter circulating half-time and lower plasma concentrations than vWf, is more useful in the assessment of disease activity in SSc.
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
systemic sclerosis, von Willebrand factor, von Willebrand factor propeptide
in
Arthritis Research & Therapy
volume
3
issue
3
pages
178 - 182
publisher
BioMed Central (BMC)
external identifiers
  • pmid:11299058
  • scopus:0035044983
ISSN
1465-9913
DOI
10.1186/ar295
language
English
LU publication?
yes
id
fec12d67-d0de-47c8-8091-bd431c9b476b (old id 1122325)
date added to LUP
2016-04-01 16:47:51
date last changed
2025-04-04 14:10:51
@article{fec12d67-d0de-47c8-8091-bd431c9b476b,
  abstract     = {{In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups. Higher values of the propeptide were observed in patients with early pulmonary involvement. A closer correlation of the propeptide than of vWf to biochemical markers of activity was also evident. Our results suggest that the propeptide, despite a shorter circulating half-time and lower plasma concentrations than vWf, is more useful in the assessment of disease activity in SSc.}},
  author       = {{Scheja, Agneta and Åkesson, Anita and Geborek, Pierre and Wildt, Marie and Wollheim, Claes B and Wollheim, Frank and Vischer, Ulrich M}},
  issn         = {{1465-9913}},
  keywords     = {{systemic sclerosis; von Willebrand factor; von Willebrand factor propeptide}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{178--182}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Arthritis Research & Therapy}},
  title        = {{Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)}},
  url          = {{http://dx.doi.org/10.1186/ar295}},
  doi          = {{10.1186/ar295}},
  volume       = {{3}},
  year         = {{2001}},
}