Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)
(2001) In Arthritis Research & Therapy 3(3). p.178-182- Abstract
- In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups. Higher values of the propeptide were observed in patients with early pulmonary involvement. A closer correlation of the propeptide than of vWf to biochemical markers of activity was also evident. Our results suggest that the propeptide, despite a shorter circulating half-time and lower plasma concentrations than vWf, is more useful in the assessment of disease activity in SSc.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1122325
- author
- Scheja, Agneta LU ; Åkesson, Anita LU ; Geborek, Pierre LU ; Wildt, Marie LU ; Wollheim, Claes B ; Wollheim, Frank LU and Vischer, Ulrich M
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- systemic sclerosis, von Willebrand factor, von Willebrand factor propeptide
- in
- Arthritis Research & Therapy
- volume
- 3
- issue
- 3
- pages
- 178 - 182
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:11299058
- scopus:0035044983
- ISSN
- 1465-9913
- DOI
- 10.1186/ar295
- language
- English
- LU publication?
- yes
- id
- fec12d67-d0de-47c8-8091-bd431c9b476b (old id 1122325)
- date added to LUP
- 2016-04-01 16:47:51
- date last changed
- 2025-04-04 14:10:51
@article{fec12d67-d0de-47c8-8091-bd431c9b476b, abstract = {{In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups. Higher values of the propeptide were observed in patients with early pulmonary involvement. A closer correlation of the propeptide than of vWf to biochemical markers of activity was also evident. Our results suggest that the propeptide, despite a shorter circulating half-time and lower plasma concentrations than vWf, is more useful in the assessment of disease activity in SSc.}}, author = {{Scheja, Agneta and Åkesson, Anita and Geborek, Pierre and Wildt, Marie and Wollheim, Claes B and Wollheim, Frank and Vischer, Ulrich M}}, issn = {{1465-9913}}, keywords = {{systemic sclerosis; von Willebrand factor; von Willebrand factor propeptide}}, language = {{eng}}, number = {{3}}, pages = {{178--182}}, publisher = {{BioMed Central (BMC)}}, series = {{Arthritis Research & Therapy}}, title = {{Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)}}, url = {{http://dx.doi.org/10.1186/ar295}}, doi = {{10.1186/ar295}}, volume = {{3}}, year = {{2001}}, }