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Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in early knee osteoarthritis.

Tiderius, Carl Johan LU ; Olsson, Lars E LU ; Leander, Peter LU ; Ekberg, Olle LU and Dahlberg, Leif LU (2003) In Magnetic Resonance in Medicine 49(3). p.488-492
Abstract
Delayed contrast-enhanced MRI of cartilage (dGEMRIC) is a noninvasive technique to study cartilage glycosaminoglycan (GAG) content in vivo. This study evaluates dGEMRIC in patients with preradiographic degenerative cartilage changes. Seventeen knees in 15 patients (age 35-70) with arthroscopically verified cartilage changes (softening and fibrillations) in the medial or lateral femoral compartment, knee pain, and normal weight-bearing radiography were included. MRI (1.5 T) was performed precontrast and at 1.5 and 3 hr after an intravenous injection of Gd-DTPA2- at 0.3 mmol/kg body weight. T1 measurements were made in regions of interest in medial and lateral femoral cartilage using sets of five turbo inversion recovery images. Precontrast,... (More)
Delayed contrast-enhanced MRI of cartilage (dGEMRIC) is a noninvasive technique to study cartilage glycosaminoglycan (GAG) content in vivo. This study evaluates dGEMRIC in patients with preradiographic degenerative cartilage changes. Seventeen knees in 15 patients (age 35-70) with arthroscopically verified cartilage changes (softening and fibrillations) in the medial or lateral femoral compartment, knee pain, and normal weight-bearing radiography were included. MRI (1.5 T) was performed precontrast and at 1.5 and 3 hr after an intravenous injection of Gd-DTPA2- at 0.3 mmol/kg body weight. T1 measurements were made in regions of interest in medial and lateral femoral cartilage using sets of five turbo inversion recovery images. Precontrast, R1 (R1 = 1/T1, 1/s) was slightly lower in diseased compared to reference compartment, indicating increased hydration (P = 0.01). Postcontrast, R1 was higher in diseased than in reference compartment at 1.5 hr, 3.45 ± 0.90 and 2.64 ± 0.58 (mean ± SD), respectively (P < 0.01), as well as at 3 hr, 2.94 ± 0.60 and 2.50 ± 0.37, respectively (P = 0.01). The washout of the contrast medium was faster in diseased cartilage as shown by a higher R1 at 1.5 than at 3 hr in the diseased but not in the reference compartment. In conclusion, dGEMRIC can identify GAG loss in early stage cartilage disease with a higher sensitivity at 1.5 than 3 hr. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
glycosaminoglycan, dGEMRIC, osteoarthritis, knee
in
Magnetic Resonance in Medicine
volume
49
issue
3
pages
488 - 492
publisher
Wiley Online Library
external identifiers
  • wos:000181297200011
  • pmid:12594751
  • scopus:0037372146
ISSN
1522-2594
DOI
10.1002/mrm.10389
language
English
LU publication?
yes
id
342e72fa-4c81-4f53-b7a2-63ac1ef24d30 (old id 112268)
date added to LUP
2007-07-30 11:47:29
date last changed
2017-07-02 03:37:44
@article{342e72fa-4c81-4f53-b7a2-63ac1ef24d30,
  abstract     = {Delayed contrast-enhanced MRI of cartilage (dGEMRIC) is a noninvasive technique to study cartilage glycosaminoglycan (GAG) content in vivo. This study evaluates dGEMRIC in patients with preradiographic degenerative cartilage changes. Seventeen knees in 15 patients (age 35-70) with arthroscopically verified cartilage changes (softening and fibrillations) in the medial or lateral femoral compartment, knee pain, and normal weight-bearing radiography were included. MRI (1.5 T) was performed precontrast and at 1.5 and 3 hr after an intravenous injection of Gd-DTPA2- at 0.3 mmol/kg body weight. T1 measurements were made in regions of interest in medial and lateral femoral cartilage using sets of five turbo inversion recovery images. Precontrast, R1 (R1 = 1/T1, 1/s) was slightly lower in diseased compared to reference compartment, indicating increased hydration (P = 0.01). Postcontrast, R1 was higher in diseased than in reference compartment at 1.5 hr, 3.45 ± 0.90 and 2.64 ± 0.58 (mean ± SD), respectively (P &lt; 0.01), as well as at 3 hr, 2.94 ± 0.60 and 2.50 ± 0.37, respectively (P = 0.01). The washout of the contrast medium was faster in diseased cartilage as shown by a higher R1 at 1.5 than at 3 hr in the diseased but not in the reference compartment. In conclusion, dGEMRIC can identify GAG loss in early stage cartilage disease with a higher sensitivity at 1.5 than 3 hr.},
  author       = {Tiderius, Carl Johan and Olsson, Lars E and Leander, Peter and Ekberg, Olle and Dahlberg, Leif},
  issn         = {1522-2594},
  keyword      = {glycosaminoglycan,dGEMRIC,osteoarthritis,knee},
  language     = {eng},
  number       = {3},
  pages        = {488--492},
  publisher    = {Wiley Online Library},
  series       = {Magnetic Resonance in Medicine},
  title        = {Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in early knee osteoarthritis.},
  url          = {http://dx.doi.org/10.1002/mrm.10389},
  volume       = {49},
  year         = {2003},
}