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Immune problems in central nervous system cell therapy

Barker, Roger A and Widner, Håkan LU (2004) In NeuroRx2004-01-01+01:002007-01-01+01:00 1(4). p.472-481
Abstract
Transplantation of cells and tissues to the mammalian brain and CNS has revived the interest in the immunological status of brain and its response to grafted tissue. The previously held view that the brain was an absolute "immunologically privileged site" allowing indefinite survival without rejection of grafts of cells has proven to be wrong. Thus, the brain should be regarded as a site where immune responses can occur, albeit in a modified form, and under certain circumstances these are as vigorous as those seen in other peripheral sites. Clinical cell transplant trials have now been performed in Parkinson's disease, Huntington's disease, demyelinating diseases, retinal disorders, stroke, epilepsy, and even deafness, and normally are... (More)
Transplantation of cells and tissues to the mammalian brain and CNS has revived the interest in the immunological status of brain and its response to grafted tissue. The previously held view that the brain was an absolute "immunologically privileged site" allowing indefinite survival without rejection of grafts of cells has proven to be wrong. Thus, the brain should be regarded as a site where immune responses can occur, albeit in a modified form, and under certain circumstances these are as vigorous as those seen in other peripheral sites. Clinical cell transplant trials have now been performed in Parkinson's disease, Huntington's disease, demyelinating diseases, retinal disorders, stroke, epilepsy, and even deafness, and normally are designed as cell replacement strategies, although implantation of genetically modified cells for supplementation of growth factors has also been tried. In addition, some disorders of the CNS for which cell therapies are being considered have an immunological basis, such as multiple sclerosis, which further complicates the situation. Embryonic neural tissue allografted into the CNS of animals and patients with neurodegenerative conditions survives, makes and receives synapses, and ameliorates behavioral deficits. The use of aborted human tissue is logistically and ethically complicated, which has lead to the search for alternative sources of cells, including xenogeneic tissue, genetically modified cells, and stem cells, all of which can and will induce some level of immune reaction. We review some of the immunological factors involved in transplantation of cells to CNS. (Less)
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type
Contribution to journal
publication status
published
subject
in
NeuroRx2004-01-01+01:002007-01-01+01:00
volume
1
issue
4
pages
472 - 481
publisher
Springer
external identifiers
  • pmid:15717048
  • scopus:18444373622
ISSN
1545-5343
DOI
10.1602/neurorx.1.4.472
language
English
LU publication?
yes
id
19c5c9bd-f20a-469e-b6b6-54850f537349 (old id 1129502)
date added to LUP
2008-06-12 14:41:44
date last changed
2017-12-17 03:49:49
@article{19c5c9bd-f20a-469e-b6b6-54850f537349,
  abstract     = {Transplantation of cells and tissues to the mammalian brain and CNS has revived the interest in the immunological status of brain and its response to grafted tissue. The previously held view that the brain was an absolute "immunologically privileged site" allowing indefinite survival without rejection of grafts of cells has proven to be wrong. Thus, the brain should be regarded as a site where immune responses can occur, albeit in a modified form, and under certain circumstances these are as vigorous as those seen in other peripheral sites. Clinical cell transplant trials have now been performed in Parkinson's disease, Huntington's disease, demyelinating diseases, retinal disorders, stroke, epilepsy, and even deafness, and normally are designed as cell replacement strategies, although implantation of genetically modified cells for supplementation of growth factors has also been tried. In addition, some disorders of the CNS for which cell therapies are being considered have an immunological basis, such as multiple sclerosis, which further complicates the situation. Embryonic neural tissue allografted into the CNS of animals and patients with neurodegenerative conditions survives, makes and receives synapses, and ameliorates behavioral deficits. The use of aborted human tissue is logistically and ethically complicated, which has lead to the search for alternative sources of cells, including xenogeneic tissue, genetically modified cells, and stem cells, all of which can and will induce some level of immune reaction. We review some of the immunological factors involved in transplantation of cells to CNS.},
  author       = {Barker, Roger A and Widner, Håkan},
  issn         = {1545-5343},
  language     = {eng},
  number       = {4},
  pages        = {472--481},
  publisher    = {Springer},
  series       = {NeuroRx2004-01-01+01:002007-01-01+01:00},
  title        = {Immune problems in central nervous system cell therapy},
  url          = {http://dx.doi.org/10.1602/neurorx.1.4.472},
  volume       = {1},
  year         = {2004},
}