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Inflammation at Birth is associated with Subnormal Development in Very Preterm Infants.

Pupp, Ingrid LU ; Hallin, Anne-Li LU ; Hellström-Westas, Lena LU ; Cilio, Corrado LU ; Berg, Ann-Cathrine LU ; Stjernqvist, Karin LU ; Fellman, Vineta LU and Ley, David LU (2008) In Pediatric Research 64. p.183-188
Abstract
Preterm birth carries a risk for impaired developmental outcome. We have previously described an association between increased levels of pro-inflammatory cytokines during the first 72 postnatal hours and cerebral damage as detected by ultrasound in a cohort of 74 very preterm infants. Sixty-seven of 71 surviving children with a mean (SD) GA of 27.1 (2.0) weeks were examined at 2 years corrected age with a standardized neurological examination and with Bayley Scales of Infant Development. We hypothesized that pro-inflammatory cytokine concentrations at or shortly after birth would be associated with an adverse developmental outcome. Increased concentrations of TNF-alpha in cord blood OR (95% CI) 3.3 (1.1-10.2), p=0.013 and at 6 h 7.8... (More)
Preterm birth carries a risk for impaired developmental outcome. We have previously described an association between increased levels of pro-inflammatory cytokines during the first 72 postnatal hours and cerebral damage as detected by ultrasound in a cohort of 74 very preterm infants. Sixty-seven of 71 surviving children with a mean (SD) GA of 27.1 (2.0) weeks were examined at 2 years corrected age with a standardized neurological examination and with Bayley Scales of Infant Development. We hypothesized that pro-inflammatory cytokine concentrations at or shortly after birth would be associated with an adverse developmental outcome. Increased concentrations of TNF-alpha in cord blood OR (95% CI) 3.3 (1.1-10.2), p=0.013 and at 6 h 7.8 (0.9-71.8), p=0.015 and of IL-6 in cord blood 1.7 (1.0-2.9), p=0.048 were associated with psychomotor developmental index <85. Increased concentrations of TNF-alpha in cord blood OR (95% CI) 3.6 (1.002-12.8), p=0.044 and of IL-8 in cord blood 3.5 (1.2-10.6), p=0.023 were associated with cerebral palsy. Associations of TNF-alpha and IL-8 in cord blood with the respective outcome measures remained significant after adjustment for other clinical variables. Pro-inflammation at birth is associated with impaired functional outcome at 2 years of corrected age in children with very preterm birth. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Research
volume
64
pages
183 - 188
publisher
International Pediatric Foundation Inc.
external identifiers
  • wos:000258022000014
  • pmid:18391842
  • scopus:52649126794
ISSN
1530-0447
DOI
10.1203/PDR.0b013e318176144d
language
English
LU publication?
yes
id
588bc072-7d7f-4a71-9e32-e7e38eff32d9 (old id 1147732)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18391842?dopt=Abstract
date added to LUP
2008-05-09 09:12:27
date last changed
2017-09-17 08:25:14
@article{588bc072-7d7f-4a71-9e32-e7e38eff32d9,
  abstract     = {Preterm birth carries a risk for impaired developmental outcome. We have previously described an association between increased levels of pro-inflammatory cytokines during the first 72 postnatal hours and cerebral damage as detected by ultrasound in a cohort of 74 very preterm infants. Sixty-seven of 71 surviving children with a mean (SD) GA of 27.1 (2.0) weeks were examined at 2 years corrected age with a standardized neurological examination and with Bayley Scales of Infant Development. We hypothesized that pro-inflammatory cytokine concentrations at or shortly after birth would be associated with an adverse developmental outcome. Increased concentrations of TNF-alpha in cord blood OR (95% CI) 3.3 (1.1-10.2), p=0.013 and at 6 h 7.8 (0.9-71.8), p=0.015 and of IL-6 in cord blood 1.7 (1.0-2.9), p=0.048 were associated with psychomotor developmental index &lt;85. Increased concentrations of TNF-alpha in cord blood OR (95% CI) 3.6 (1.002-12.8), p=0.044 and of IL-8 in cord blood 3.5 (1.2-10.6), p=0.023 were associated with cerebral palsy. Associations of TNF-alpha and IL-8 in cord blood with the respective outcome measures remained significant after adjustment for other clinical variables. Pro-inflammation at birth is associated with impaired functional outcome at 2 years of corrected age in children with very preterm birth.},
  author       = {Pupp, Ingrid and Hallin, Anne-Li and Hellström-Westas, Lena and Cilio, Corrado and Berg, Ann-Cathrine and Stjernqvist, Karin and Fellman, Vineta and Ley, David},
  issn         = {1530-0447},
  language     = {eng},
  pages        = {183--188},
  publisher    = {International Pediatric Foundation Inc.},
  series       = {Pediatric Research},
  title        = {Inflammation at Birth is associated with Subnormal Development in Very Preterm Infants.},
  url          = {http://dx.doi.org/10.1203/PDR.0b013e318176144d},
  volume       = {64},
  year         = {2008},
}