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Tissue reactions evoked by porous and plane surfaces made out of silicon and titanium.

Rosengren, Agneta LU ; Wallman, Lars LU ; Danielsen, Nils LU ; Laurell, Thomas LU and Bjursten, Lars Magnus LU (2002) In IEEE Transactions on Biomedical Engineering 49(4). p.392-399
Abstract
Square-shaped silicon or titanium implants with plane or porous surfaces surrounded by a rim of silicone were implanted in the rat abdominal wall for evaluation of the tissue response after one, six, or 12 weeks. Cell damage was identified as increased membrane permeability using fluorescence microscopy by injection of propidium iodide prior to the killing of the rats. Capsule thickness and immunohistochemical quantification of macrophages were used as a further measure of the foreign-body reaction. There were no significant differences in capsular cell densities for macrophages, total cells (macrophages, fibroblasts, and other cells), or necrotic cells at the different time points for the four surfaces studied. However, significant... (More)
Square-shaped silicon or titanium implants with plane or porous surfaces surrounded by a rim of silicone were implanted in the rat abdominal wall for evaluation of the tissue response after one, six, or 12 weeks. Cell damage was identified as increased membrane permeability using fluorescence microscopy by injection of propidium iodide prior to the killing of the rats. Capsule thickness and immunohistochemical quantification of macrophages were used as a further measure of the foreign-body reaction. There were no significant differences in capsular cell densities for macrophages, total cells (macrophages, fibroblasts, and other cells), or necrotic cells at the different time points for the four surfaces studied. However, significant differences in the kinetics of the response were found between plane surfaces compared with porous ones. Both types of plane surfaces developed a significant increase in capsule thickness over time in contrast to the porous implants. Porous silicon displayed a significant decrease in total cells in the reactive capsule over time. Furthermore, porous silicon and titanium surfaces displayed a significant decrease in total cell numbers at the implant interface between six and 12 weeks. The present study demonstrated that implanted silicon elicited soft-tissue reactions comparable to that of titanium (Less)
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; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Rats, Prosthesis Design, Titanium, Support, Non-U.S. Gov't, Nonparametric, Statistics, Sprague-Dawley, Silicon, Foreign-Body Reaction: pathology, Cell Membrane Permeability, Image Processing, Animal, Biocompatible Materials, Microscopy, Abdominal Muscles, Male, Immunoenzyme Techniques, Computer-Assisted, Prostheses and Implants: adverse effects, Fluorescence
in
IEEE Transactions on Biomedical Engineering
volume
49
issue
4
pages
392 - 399
publisher
IEEE - Institute of Electrical and Electronics Engineers Inc.
external identifiers
  • wos:000174524700013
  • pmid:11942731
  • scopus:0036130785
ISSN
1558-2531
DOI
10.1109/10.991167
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Biomedical Engineering (011200011), Surgery Research Unit (013242220), Neuroendocrine Cell Biology (013212008), Neural Interfaces (013212003), Department of Clinical Sciences, Malmö (013240000)
id
74621a3b-a589-4396-a111-d9ac3f4412b8 (old id 115447)
date added to LUP
2016-04-01 15:28:54
date last changed
2020-02-26 04:52:58
@article{74621a3b-a589-4396-a111-d9ac3f4412b8,
  abstract     = {Square-shaped silicon or titanium implants with plane or porous surfaces surrounded by a rim of silicone were implanted in the rat abdominal wall for evaluation of the tissue response after one, six, or 12 weeks. Cell damage was identified as increased membrane permeability using fluorescence microscopy by injection of propidium iodide prior to the killing of the rats. Capsule thickness and immunohistochemical quantification of macrophages were used as a further measure of the foreign-body reaction. There were no significant differences in capsular cell densities for macrophages, total cells (macrophages, fibroblasts, and other cells), or necrotic cells at the different time points for the four surfaces studied. However, significant differences in the kinetics of the response were found between plane surfaces compared with porous ones. Both types of plane surfaces developed a significant increase in capsule thickness over time in contrast to the porous implants. Porous silicon displayed a significant decrease in total cells in the reactive capsule over time. Furthermore, porous silicon and titanium surfaces displayed a significant decrease in total cell numbers at the implant interface between six and 12 weeks. The present study demonstrated that implanted silicon elicited soft-tissue reactions comparable to that of titanium},
  author       = {Rosengren, Agneta and Wallman, Lars and Danielsen, Nils and Laurell, Thomas and Bjursten, Lars Magnus},
  issn         = {1558-2531},
  language     = {eng},
  number       = {4},
  pages        = {392--399},
  publisher    = {IEEE - Institute of Electrical and Electronics Engineers Inc.},
  series       = {IEEE Transactions on Biomedical Engineering},
  title        = {Tissue reactions evoked by porous and plane surfaces made out of silicon and titanium.},
  url          = {https://lup.lub.lu.se/search/ws/files/4401721/623801.pdf},
  doi          = {10.1109/10.991167},
  volume       = {49},
  year         = {2002},
}