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Improving outcome after stroke: Overcoming the translational roadblock

Endres, Matthias; Engelhardt, Britta; Koistinaho, Jari; Lindvall, Olle LU ; Meairs, Stephen; Mohr, Jay P.; Planas, Anna; Rothwell, Nancy; Schwaninger, Markus and Schwab, Martin E., et al. (2008) In Cerebrovascular Diseases 25(3). p.268-278
Abstract
Stroke poses a massive burden of disease, yet we have few effective therapies. The paucity of therapeutic options stands contrary to intensive research efforts. The failure of these past investments demands a thorough re-examination of the pathophysiology of ischaemic brain injury. Several critical areas hold the key to overcoming the translational roadblock: (1) vascular occlusion: current recanalization strategies have limited effectiveness and may have serious side effects; (2) complexity of stroke pathobiology: therapy must acknowledge the 'Janus-faced' nature of many stroke targets and must identify endogenous neuroprotective and repair mechanisms; repair; stroke outcome is modulated by the interaction of the injured brain with the... (More)
Stroke poses a massive burden of disease, yet we have few effective therapies. The paucity of therapeutic options stands contrary to intensive research efforts. The failure of these past investments demands a thorough re-examination of the pathophysiology of ischaemic brain injury. Several critical areas hold the key to overcoming the translational roadblock: (1) vascular occlusion: current recanalization strategies have limited effectiveness and may have serious side effects; (2) complexity of stroke pathobiology: therapy must acknowledge the 'Janus-faced' nature of many stroke targets and must identify endogenous neuroprotective and repair mechanisms; repair; stroke outcome is modulated by the interaction of the injured brain with the immune system; (4) regeneration: the potential of the brain for reorganization, plasticity and repair after injury is much greater than previously thought; (5) confounding factors, long-term outcome and predictive modelling. These 5 areas are linked on all levels and therefore need to be tackled by an integrative approach and innovative therapeutic strategies. (Less)
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publishing date
type
Contribution to journal
publication status
published
subject
keywords
stroke treatment, neuroprotection, brain ischaemia
in
Cerebrovascular Diseases
volume
25
issue
3
pages
268 - 278
publisher
Karger
external identifiers
  • wos:000253911800011
  • scopus:41349117677
ISSN
1421-9786
DOI
10.1159/000118039
language
English
LU publication?
yes
id
86e57c9a-c1ec-498f-b4f0-07bf800e2d41 (old id 1191487)
date added to LUP
2008-09-08 16:31:09
date last changed
2017-09-17 04:55:32
@article{86e57c9a-c1ec-498f-b4f0-07bf800e2d41,
  abstract     = {Stroke poses a massive burden of disease, yet we have few effective therapies. The paucity of therapeutic options stands contrary to intensive research efforts. The failure of these past investments demands a thorough re-examination of the pathophysiology of ischaemic brain injury. Several critical areas hold the key to overcoming the translational roadblock: (1) vascular occlusion: current recanalization strategies have limited effectiveness and may have serious side effects; (2) complexity of stroke pathobiology: therapy must acknowledge the 'Janus-faced' nature of many stroke targets and must identify endogenous neuroprotective and repair mechanisms; repair; stroke outcome is modulated by the interaction of the injured brain with the immune system; (4) regeneration: the potential of the brain for reorganization, plasticity and repair after injury is much greater than previously thought; (5) confounding factors, long-term outcome and predictive modelling. These 5 areas are linked on all levels and therefore need to be tackled by an integrative approach and innovative therapeutic strategies.},
  author       = {Endres, Matthias and Engelhardt, Britta and Koistinaho, Jari and Lindvall, Olle and Meairs, Stephen and Mohr, Jay P. and Planas, Anna and Rothwell, Nancy and Schwaninger, Markus and Schwab, Martin E. and Vivien, Denis and Wieloch, Tadeusz and Dirnagl, Ulrich},
  issn         = {1421-9786},
  keyword      = {stroke treatment,neuroprotection,brain ischaemia},
  language     = {eng},
  number       = {3},
  pages        = {268--278},
  publisher    = {Karger},
  series       = {Cerebrovascular Diseases},
  title        = {Improving outcome after stroke: Overcoming the translational roadblock},
  url          = {http://dx.doi.org/10.1159/000118039},
  volume       = {25},
  year         = {2008},
}