Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes
Cervin, Camilla LU ; Lyssenko, Valeriya LU ; Bakhtadze, Ekaterine LU ; Lindholm, Eero LU ; Nilsson, Peter LU ; Tuomi, Tiinamaija LU
; Cilio, Corrado
LU
and Groop, Leif
LU
(2008)
In Diabetes
57(5).
p.1433-1437
- Abstract
- OBJECTIVE-Latent autoimmune diabetes in adults (LADA) is often considered a slowly progressing subtype of type 1 diabetes, although the clinical picture more resembles type 2 diabetes. One way to improve classification is to study whether LADA shares genetic features with type 1 and/or type 2 diabetes. RESEARCH DESIGN AND METHODS-To accomplish this we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type I diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA, 718 type 1 diabetic, and 1,676 type 2 diabetic patients, as well as 1,704 healthy control subjects from Sweden and Finland. RESULTS-LADA subjects showed, compared with type 2 diabetic patients, increased frequency of risk for the... (More)
- OBJECTIVE-Latent autoimmune diabetes in adults (LADA) is often considered a slowly progressing subtype of type 1 diabetes, although the clinical picture more resembles type 2 diabetes. One way to improve classification is to study whether LADA shares genetic features with type 1 and/or type 2 diabetes. RESEARCH DESIGN AND METHODS-To accomplish this we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type I diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA, 718 type 1 diabetic, and 1,676 type 2 diabetic patients, as well as 1,704 healthy control subjects from Sweden and Finland. RESULTS-LADA subjects showed, compared with type 2 diabetic patients, increased frequency of risk for the HLA-DQB1 *0201/*0302 genotype (27 vs. 6.9%; P < 1 X 10(-6)), with similar frequency as with type I diabetes (36%). In addition, LADA subjects showed higher frequencies of protective HLA-DQB1 *0602(3)/X than type I diabetic patients (8.1 vs. 3.2%, P = 0.003). The AA genotype of rs689, referring to the class I allele in the INS VNTR, as well as the CT/TT genotypes of rs2476601 in the PTPN22 gene, were increased both in type 1 diabetic (P = 3 X 10(-14) and P = 1 X 10(-10), respectively) and LADA (P = 0.001 and P = 0.002) subjects compared with control subjects. Notably, the frequency of the type 2 diabetes-associated CT/TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects (52.8%; P = 0.03), to the same extent as in type 2 diabetic subjects (54.1%, P = 3 X 10(-7)), compared with control subjects (44.8%) and type I diabetic subjects (43.39%). CONCLUSIONS-LADA shares genetic features with both type I (HLA, INS VNTR, and PTPN22) and type 2 (TCF7L2) diabetes, which justifies considering LADA as an admixture of the two major types of diabetes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1204808
- author
- Cervin, Camilla
LU
; Lyssenko, Valeriya
LU
; Bakhtadze, Ekaterine
LU
; Lindholm, Eero
LU
; Nilsson, Peter
LU
; Tuomi, Tiinamaija
LU
; Cilio, Corrado
LU
and Groop, Leif
LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes
- volume
- 57
- issue
- 5
- pages
- 1433 - 1437
- publisher
- American Diabetes Association Inc.
- external identifiers
-
- wos:000255628700037
- pmid:18310307
- scopus:48449092224
- pmid:18310307
- ISSN
- 1939-327X
- DOI
- 10.2337/db07-0299
- language
- English
- LU publication?
- yes
- id
- d33918cc-873b-4e96-a6fb-149d25f5b26b (old id 1204808)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18310307?dopt=Abstract
- date added to LUP
- 2016-04-01 11:41:11
- date last changed
- 2024-05-07 11:15:19
@article{d33918cc-873b-4e96-a6fb-149d25f5b26b,
abstract = {{OBJECTIVE-Latent autoimmune diabetes in adults (LADA) is often considered a slowly progressing subtype of type 1 diabetes, although the clinical picture more resembles type 2 diabetes. One way to improve classification is to study whether LADA shares genetic features with type 1 and/or type 2 diabetes. RESEARCH DESIGN AND METHODS-To accomplish this we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type I diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA, 718 type 1 diabetic, and 1,676 type 2 diabetic patients, as well as 1,704 healthy control subjects from Sweden and Finland. RESULTS-LADA subjects showed, compared with type 2 diabetic patients, increased frequency of risk for the HLA-DQB1 *0201/*0302 genotype (27 vs. 6.9%; P < 1 X 10(-6)), with similar frequency as with type I diabetes (36%). In addition, LADA subjects showed higher frequencies of protective HLA-DQB1 *0602(3)/X than type I diabetic patients (8.1 vs. 3.2%, P = 0.003). The AA genotype of rs689, referring to the class I allele in the INS VNTR, as well as the CT/TT genotypes of rs2476601 in the PTPN22 gene, were increased both in type 1 diabetic (P = 3 X 10(-14) and P = 1 X 10(-10), respectively) and LADA (P = 0.001 and P = 0.002) subjects compared with control subjects. Notably, the frequency of the type 2 diabetes-associated CT/TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects (52.8%; P = 0.03), to the same extent as in type 2 diabetic subjects (54.1%, P = 3 X 10(-7)), compared with control subjects (44.8%) and type I diabetic subjects (43.39%). CONCLUSIONS-LADA shares genetic features with both type I (HLA, INS VNTR, and PTPN22) and type 2 (TCF7L2) diabetes, which justifies considering LADA as an admixture of the two major types of diabetes.}},
author = {{Cervin, Camilla and Lyssenko, Valeriya and Bakhtadze, Ekaterine and Lindholm, Eero and Nilsson, Peter and Tuomi, Tiinamaija and Cilio, Corrado and Groop, Leif}},
issn = {{1939-327X}},
language = {{eng}},
number = {{5}},
pages = {{1433--1437}},
publisher = {{American Diabetes Association Inc.}},
series = {{Diabetes}},
title = {{Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes}},
url = {{http://dx.doi.org/10.2337/db07-0299}},
doi = {{10.2337/db07-0299}},
volume = {{57}},
year = {{2008}},
}