Advanced

Smoking and lymphoma risk in the european prospective investigation into cancer and nutrition

Nieters, Alexandra; Rohrmann, Sabine; Becker, Nikolaus; Linseisen, Jakob; Ruediger, Thomas; Overvad, Kim; Tjonneland, Anne; Olsen, Anja; Allen, Naomi E. and Travis, Ruth C., et al. (2008) In American Journal of Epidemiology 167(9). p.1081-1089
Abstract
Lymphomas are one of the few cancers that have been increasing in incidence over the past decades. So far, only a few established risk factors have been identified, including immunosuppression and viral infections. Recent evidence suggests etiologic heterogeneity of different lymphoma subtypes. Smoking may affect risk differently, depending on the lymphoma entity. The European Prospective Investigation into Cancer and Nutrition was used to study the role of smoking in the etiology of lymphomas and individual subtypes within a prospective study. Information on baseline and lifetime tobacco smoking by 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted... (More)
Lymphomas are one of the few cancers that have been increasing in incidence over the past decades. So far, only a few established risk factors have been identified, including immunosuppression and viral infections. Recent evidence suggests etiologic heterogeneity of different lymphoma subtypes. Smoking may affect risk differently, depending on the lymphoma entity. The European Prospective Investigation into Cancer and Nutrition was used to study the role of smoking in the etiology of lymphomas and individual subtypes within a prospective study. Information on baseline and lifetime tobacco smoking by 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted hazard ratios and 95% confidence intervals. During 3,567,410 person-years of follow-up, 1,371 lymphoma cases (1,304 non-Hodgkin's lymphomas and 67 Hodgkin's lymphomas) were identified. Relative risk for smokers at recruitment was more than twofold higher for Hodgkin's lymphoma (hazard ratio = 2.14, 95% confidence interval: 1.18, 3.87) but was not elevated for non-Hodgkin's lymphoma (hazard ratio = 1.06, 95% confidence interval: 0.94, 1.19) and individual B-cell non-Hodgkin's lymphoma subtypes. In this prospective study, smoking appeared to increase Hodgkin's lymphoma risk consistently in both genders, whereas B-cell non-Hodgkin's lymphoma risk was not associated. Future analysis should involve viral biomarkers and genetic susceptibility markers to elucidate potential mechanisms of smoking-induced carcinogenesis, particularly for Hodgkin's lymphoma. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
prospective studies, lymphoma, risk factors, smoking
in
American Journal of Epidemiology
volume
167
issue
9
pages
1081 - 1089
publisher
Oxford University Press
external identifiers
  • wos:000255310200008
  • scopus:42649144776
ISSN
0002-9262
DOI
10.1093/aje/kwn004
language
English
LU publication?
yes
id
a97bdd2b-7d58-4320-a1fd-c0f3d91b60a8 (old id 1205398)
date added to LUP
2008-09-18 15:26:05
date last changed
2017-09-10 03:52:16
@article{a97bdd2b-7d58-4320-a1fd-c0f3d91b60a8,
  abstract     = {Lymphomas are one of the few cancers that have been increasing in incidence over the past decades. So far, only a few established risk factors have been identified, including immunosuppression and viral infections. Recent evidence suggests etiologic heterogeneity of different lymphoma subtypes. Smoking may affect risk differently, depending on the lymphoma entity. The European Prospective Investigation into Cancer and Nutrition was used to study the role of smoking in the etiology of lymphomas and individual subtypes within a prospective study. Information on baseline and lifetime tobacco smoking by 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted hazard ratios and 95% confidence intervals. During 3,567,410 person-years of follow-up, 1,371 lymphoma cases (1,304 non-Hodgkin's lymphomas and 67 Hodgkin's lymphomas) were identified. Relative risk for smokers at recruitment was more than twofold higher for Hodgkin's lymphoma (hazard ratio = 2.14, 95% confidence interval: 1.18, 3.87) but was not elevated for non-Hodgkin's lymphoma (hazard ratio = 1.06, 95% confidence interval: 0.94, 1.19) and individual B-cell non-Hodgkin's lymphoma subtypes. In this prospective study, smoking appeared to increase Hodgkin's lymphoma risk consistently in both genders, whereas B-cell non-Hodgkin's lymphoma risk was not associated. Future analysis should involve viral biomarkers and genetic susceptibility markers to elucidate potential mechanisms of smoking-induced carcinogenesis, particularly for Hodgkin's lymphoma.},
  author       = {Nieters, Alexandra and Rohrmann, Sabine and Becker, Nikolaus and Linseisen, Jakob and Ruediger, Thomas and Overvad, Kim and Tjonneland, Anne and Olsen, Anja and Allen, Naomi E. and Travis, Ruth C. and Bingham, Sheila and Khaw, Kay-Tee and Ardanaz, Eva and Redondo, M. L. and Basterrechea, Mikel and Martinez, Carmen and Tormo, Maria-Jose and Rosso, Stefano and Tagliabue, Giovanna and Masala, Giovanna and Mattiello, Amalia and Tumino, Rosario and Boeing, Heiner and Bergmann, Manuela and Kaaks, Rudolf and Trichopoulou, Antonia and Trichopoulos, Dimitrios and Peeters, Petra H. and Bueno-de-Mesquita, Bas and Boffetta, Paolo and Brennan, Paul and Ferrari, Pietro and Neasham, David and Lund, Eiliv and Berglund, Göran and Manjer, Jonas and Hallmans, Göran and Johansson, Ingegerd and Vineis, Paolo and Riboli, Elio},
  issn         = {0002-9262},
  keyword      = {prospective studies,lymphoma,risk factors,smoking},
  language     = {eng},
  number       = {9},
  pages        = {1081--1089},
  publisher    = {Oxford University Press},
  series       = {American Journal of Epidemiology},
  title        = {Smoking and lymphoma risk in the european prospective investigation into cancer and nutrition},
  url          = {http://dx.doi.org/10.1093/aje/kwn004},
  volume       = {167},
  year         = {2008},
}