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Short-term outcome predictors in infants born at 23-24 gestational weeks

Forsblad, Kristina LU ; Källén, Karin LU ; Marsal, Karel LU and Hellström-Westas, Lena LU (2008) In Acta Pædiatrica 97(5). p.551-556
Abstract
Aim: Outcome is uncertain in infants born at 23-24 gestational weeks. The aim of the present study was to identify possible early predictors of outcome in these infants. Materials and Methods: Data from the Swedish medical birth register (MBR) for live-born infants with gestational ages (GAs) 23 and 24 weeks, born during the time-period 2000-2002, were analysed in relation to short-term outcomes, that is survival and survival without severe brain damage (intraventricular haemorrhage [IVH] grades 3 and 4 and/or periventricular leukomalacia [PVL]). Results: In 57 infants born at 23 gestational weeks, survival was associated with birthweight (BW) (p = 0.018) and 5-min Apgar score (p = 0.020) on univariate analyses. In 99 infants born at 24... (More)
Aim: Outcome is uncertain in infants born at 23-24 gestational weeks. The aim of the present study was to identify possible early predictors of outcome in these infants. Materials and Methods: Data from the Swedish medical birth register (MBR) for live-born infants with gestational ages (GAs) 23 and 24 weeks, born during the time-period 2000-2002, were analysed in relation to short-term outcomes, that is survival and survival without severe brain damage (intraventricular haemorrhage [IVH] grades 3 and 4 and/or periventricular leukomalacia [PVL]). Results: In 57 infants born at 23 gestational weeks, survival was associated with birthweight (BW) (p = 0.018) and 5-min Apgar score (p = 0.020) on univariate analyses. In 99 infants born at 24 weeks of gestation, survival without severe brain damage correlated with BW (p = 0.039), birth type (singleton/multiple) (p = 0.017) and Apgar score at 1, 5 and 10 min (p = 0.028, 0.014 and 0.030, respectively). The best model for predicting survival without severe brain damage in infants born at 24 gestational weeks was based on 5-min Apgar score and birth type. The small number of live-born infants at 23 weeks of gestation did not allow for multiple logistic regression analyses. Conclusion: The 5-min Apgar score is associated with short-term outcome in live-born infants at 23-24 gestational weeks. The association is stronger for infants born at 24 weeks of gestation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
survival, prognosis, preterm, Apgar score, outcome
in
Acta Pædiatrica
volume
97
issue
5
pages
551 - 556
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000254988600009
  • scopus:41749125030
ISSN
1651-2227
DOI
10.1111/j.1651-2227.2008.00737.x
language
English
LU publication?
yes
id
dd4f1eee-9b94-43d6-8154-5d93987c4ed8 (old id 1206550)
date added to LUP
2008-08-28 14:04:35
date last changed
2017-04-23 04:05:56
@article{dd4f1eee-9b94-43d6-8154-5d93987c4ed8,
  abstract     = {Aim: Outcome is uncertain in infants born at 23-24 gestational weeks. The aim of the present study was to identify possible early predictors of outcome in these infants. Materials and Methods: Data from the Swedish medical birth register (MBR) for live-born infants with gestational ages (GAs) 23 and 24 weeks, born during the time-period 2000-2002, were analysed in relation to short-term outcomes, that is survival and survival without severe brain damage (intraventricular haemorrhage [IVH] grades 3 and 4 and/or periventricular leukomalacia [PVL]). Results: In 57 infants born at 23 gestational weeks, survival was associated with birthweight (BW) (p = 0.018) and 5-min Apgar score (p = 0.020) on univariate analyses. In 99 infants born at 24 weeks of gestation, survival without severe brain damage correlated with BW (p = 0.039), birth type (singleton/multiple) (p = 0.017) and Apgar score at 1, 5 and 10 min (p = 0.028, 0.014 and 0.030, respectively). The best model for predicting survival without severe brain damage in infants born at 24 gestational weeks was based on 5-min Apgar score and birth type. The small number of live-born infants at 23 weeks of gestation did not allow for multiple logistic regression analyses. Conclusion: The 5-min Apgar score is associated with short-term outcome in live-born infants at 23-24 gestational weeks. The association is stronger for infants born at 24 weeks of gestation.},
  author       = {Forsblad, Kristina and Källén, Karin and Marsal, Karel and Hellström-Westas, Lena},
  issn         = {1651-2227},
  keyword      = {survival,prognosis,preterm,Apgar score,outcome},
  language     = {eng},
  number       = {5},
  pages        = {551--556},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta Pædiatrica},
  title        = {Short-term outcome predictors in infants born at 23-24 gestational weeks},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.2008.00737.x},
  volume       = {97},
  year         = {2008},
}