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Free-breathing fetal cardiac MRI with doppler ultrasound gating, compressed sensing, and motion compensation

Haris, Kostas LU ; Hedström, Erik LU ; Kording, Fabian ; Bidhult, Sebastian LU ; Steding-Ehrenborg, Katarina LU ; Ruprecht, Christian ; Heiberg, Einar LU ; Arheden, Håkan LU and Aletras, Anthony H LU (2020) In Journal of Magnetic Resonance Imaging 51(1). p.260-272
Abstract

BACKGROUND: Fetal cardiovascular MRI complements ultrasound to assess fetal cardiovascular pathophysiology.

PURPOSE: To develop a free-breathing method for retrospective fetal cine MRI using Doppler ultrasound (DUS) cardiac gating and tiny golden angle radial sampling (tyGRASP) for accelerated acquisition capable of detecting fetal movements for motion compensation.

STUDY TYPE: Feasibility study.

SUBJECTS: Nine volunteers (gestational week 34-40). Short-axis and four-chamber views were acquired during maternal free-breathing and breath-hold.

FIELD STRENGTH/SEQUENCE: 1.5T cine balanced steady-state free precession.

ASSESSMENT: A self-gated reconstruction method was improved for clinical application by using... (More)

BACKGROUND: Fetal cardiovascular MRI complements ultrasound to assess fetal cardiovascular pathophysiology.

PURPOSE: To develop a free-breathing method for retrospective fetal cine MRI using Doppler ultrasound (DUS) cardiac gating and tiny golden angle radial sampling (tyGRASP) for accelerated acquisition capable of detecting fetal movements for motion compensation.

STUDY TYPE: Feasibility study.

SUBJECTS: Nine volunteers (gestational week 34-40). Short-axis and four-chamber views were acquired during maternal free-breathing and breath-hold.

FIELD STRENGTH/SEQUENCE: 1.5T cine balanced steady-state free precession.

ASSESSMENT: A self-gated reconstruction method was improved for clinical application by using 1) retrospective DUS gating, and 2) motion detection and rejection/correction algorithms for compensating for fetal motion. The free-breathing reconstructions were qualitatively and quantitatively assessed, and DUS-gating was compared with self-gating in breath-hold reconstructions. A scoring of 1-4 for overall image quality, cardiac, and extracardiac diagnostic quality was used.

STATISTICAL TESTS: Friedman's test was used to assess differences in qualitative scoring between observers. A Wilcoxon matched-pairs signed rank test was used to assess differences between breath-hold and free-breathing acquisitions and between observers' quantitative measurements.

RESULTS: In all cases, 111 free-breathing and 145 breath-hold acquisitions, the automatically calculated DUS-based cardiac gating signal provided reconstructions of diagnostic quality (median score 4, range 1-4). Free-breathing did not affect the DUS-based cardiac gated retrospective radial reconstruction with respect to image or diagnostic quality (all P > 0.06). Motion detection with rejection/correction in k-space produced high-quality free-breathing DUS-based reconstructions [median 3, range (2-4)], whereas free-breathing self-gated methods failed in 80 out of 88 cases to produce a stable gating signal.

DATA CONCLUSION: Free-breathing fetal cine cardiac MRI based on DUS gating and tyGRASP with motion compensation yields diagnostic images. This simplifies acquisition for the pregnant woman and thus could help increase fetal cardiac MRI acceptance in the clinic.

LEVEL OF EVIDENCE: 2 Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2019.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Magnetic Resonance Imaging
volume
51
issue
1
pages
260 - 272
publisher
John Wiley & Sons
external identifiers
  • scopus:85076371992
  • pmid:31228302
ISSN
1522-2586
DOI
10.1002/jmri.26842
language
English
LU publication?
yes
additional info
© 2019 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.
id
120793f7-f45e-484a-9373-d7556a139bac
date added to LUP
2019-06-25 20:01:55
date last changed
2020-01-14 14:19:56
@article{120793f7-f45e-484a-9373-d7556a139bac,
  abstract     = {<p>BACKGROUND: Fetal cardiovascular MRI complements ultrasound to assess fetal cardiovascular pathophysiology.</p><p>PURPOSE: To develop a free-breathing method for retrospective fetal cine MRI using Doppler ultrasound (DUS) cardiac gating and tiny golden angle radial sampling (tyGRASP) for accelerated acquisition capable of detecting fetal movements for motion compensation.</p><p>STUDY TYPE: Feasibility study.</p><p>SUBJECTS: Nine volunteers (gestational week 34-40). Short-axis and four-chamber views were acquired during maternal free-breathing and breath-hold.</p><p>FIELD STRENGTH/SEQUENCE: 1.5T cine balanced steady-state free precession.</p><p>ASSESSMENT: A self-gated reconstruction method was improved for clinical application by using 1) retrospective DUS gating, and 2) motion detection and rejection/correction algorithms for compensating for fetal motion. The free-breathing reconstructions were qualitatively and quantitatively assessed, and DUS-gating was compared with self-gating in breath-hold reconstructions. A scoring of 1-4 for overall image quality, cardiac, and extracardiac diagnostic quality was used.</p><p>STATISTICAL TESTS: Friedman's test was used to assess differences in qualitative scoring between observers. A Wilcoxon matched-pairs signed rank test was used to assess differences between breath-hold and free-breathing acquisitions and between observers' quantitative measurements.</p><p>RESULTS: In all cases, 111 free-breathing and 145 breath-hold acquisitions, the automatically calculated DUS-based cardiac gating signal provided reconstructions of diagnostic quality (median score 4, range 1-4). Free-breathing did not affect the DUS-based cardiac gated retrospective radial reconstruction with respect to image or diagnostic quality (all P &gt; 0.06). Motion detection with rejection/correction in k-space produced high-quality free-breathing DUS-based reconstructions [median 3, range (2-4)], whereas free-breathing self-gated methods failed in 80 out of 88 cases to produce a stable gating signal.</p><p>DATA CONCLUSION: Free-breathing fetal cine cardiac MRI based on DUS gating and tyGRASP with motion compensation yields diagnostic images. This simplifies acquisition for the pregnant woman and thus could help increase fetal cardiac MRI acceptance in the clinic.</p><p>LEVEL OF EVIDENCE: 2 Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2019.</p>},
  author       = {Haris, Kostas and Hedström, Erik and Kording, Fabian and Bidhult, Sebastian and Steding-Ehrenborg, Katarina and Ruprecht, Christian and Heiberg, Einar and Arheden, Håkan and Aletras, Anthony H},
  issn         = {1522-2586},
  language     = {eng},
  number       = {1},
  pages        = {260--272},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Magnetic Resonance Imaging},
  title        = {Free-breathing fetal cardiac MRI with doppler ultrasound gating, compressed sensing, and motion compensation},
  url          = {http://dx.doi.org/10.1002/jmri.26842},
  doi          = {10.1002/jmri.26842},
  volume       = {51},
  year         = {2020},
}