Associations between food patterns defined by cluster analysis and colorectal cancer incidence in the NIH-AARP diet and health study.
(2009) In European Journal of Clinical Nutrition 63. p.707-717- Abstract
- Background/Objectives:To examine associations between food patterns, constructed with cluster analysis, and colorectal cancer incidence within the National Institutes of Health-AARP Diet and Health Study.Subjects/Methods:A prospective cohort, aged 50-71 years at baseline in 1995-1996, followed until the end of 2000. Food patterns were constructed, separately in men (n=293 576) and women (n=198 730), with 181 food variables (daily intake frequency per 1000 kcal) from a food frequency questionnaire. Four large clusters were identified in men and three in women. Cox proportional hazards regression examined associations between patterns and cancer incidence.Results:In men, a vegetable and fruit pattern was associated with reduced colorectal... (More)
- Background/Objectives:To examine associations between food patterns, constructed with cluster analysis, and colorectal cancer incidence within the National Institutes of Health-AARP Diet and Health Study.Subjects/Methods:A prospective cohort, aged 50-71 years at baseline in 1995-1996, followed until the end of 2000. Food patterns were constructed, separately in men (n=293 576) and women (n=198 730), with 181 food variables (daily intake frequency per 1000 kcal) from a food frequency questionnaire. Four large clusters were identified in men and three in women. Cox proportional hazards regression examined associations between patterns and cancer incidence.Results:In men, a vegetable and fruit pattern was associated with reduced colorectal cancer incidence (multivariate hazard ratio, HR: 0.85; 95% confidence interval, CI: 0.76, 0.94), when compared to less salutary food choices. Both the vegetable and fruit pattern and a fat-reduced foods pattern were associated with reduced rectal cancer incidence in men. In women, a similar vegetable and fruit pattern was associated with colorectal cancer protection (age-adjusted HR: 0.82; 95% CI: 0.70, 0.95), but the association was not statistically significant in multivariate analysis.Conclusions:These results, together with findings from previous studies support the hypothesis that micronutrient dense, low-fat, high-fiber food patterns protect against colorectal cancer.European Journal of Clinical Nutrition advance online publication, 6 August 2008; doi:10.1038/ejcn.2008.40. (Less)
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https://lup.lub.lu.se/record/1223409
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- 2009
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- Contribution to journal
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- published
- subject
- in
- European Journal of Clinical Nutrition
- volume
- 63
- pages
- 707 - 717
- publisher
- Nature Publishing Group
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-
- wos:000266572000001
- pmid:18685556
- scopus:67549121649
- pmid:18685556
- ISSN
- 1476-5640
- DOI
- 10.1038/ejcn.2008.40
- language
- English
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- yes
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- 2cfd6e6e-d6fa-497c-95fb-01eb38cea92d (old id 1223409)
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- http://www.ncbi.nlm.nih.gov/pubmed/18685556?dopt=Abstract
- date added to LUP
- 2016-04-04 09:13:46
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- 2022-01-29 08:55:17
@article{2cfd6e6e-d6fa-497c-95fb-01eb38cea92d, abstract = {{Background/Objectives:To examine associations between food patterns, constructed with cluster analysis, and colorectal cancer incidence within the National Institutes of Health-AARP Diet and Health Study.Subjects/Methods:A prospective cohort, aged 50-71 years at baseline in 1995-1996, followed until the end of 2000. Food patterns were constructed, separately in men (n=293 576) and women (n=198 730), with 181 food variables (daily intake frequency per 1000 kcal) from a food frequency questionnaire. Four large clusters were identified in men and three in women. Cox proportional hazards regression examined associations between patterns and cancer incidence.Results:In men, a vegetable and fruit pattern was associated with reduced colorectal cancer incidence (multivariate hazard ratio, HR: 0.85; 95% confidence interval, CI: 0.76, 0.94), when compared to less salutary food choices. Both the vegetable and fruit pattern and a fat-reduced foods pattern were associated with reduced rectal cancer incidence in men. In women, a similar vegetable and fruit pattern was associated with colorectal cancer protection (age-adjusted HR: 0.82; 95% CI: 0.70, 0.95), but the association was not statistically significant in multivariate analysis.Conclusions:These results, together with findings from previous studies support the hypothesis that micronutrient dense, low-fat, high-fiber food patterns protect against colorectal cancer.European Journal of Clinical Nutrition advance online publication, 6 August 2008; doi:10.1038/ejcn.2008.40.}}, author = {{Wirfält, Elisabet and Midthune, D and Reedy, J and Mitrou, P and Flood, A and Subar, A F and Leitzmann, M and Mouw, T and Hollenbeck, A R and Schatzkin, A and Kipnis, V}}, issn = {{1476-5640}}, language = {{eng}}, pages = {{707--717}}, publisher = {{Nature Publishing Group}}, series = {{European Journal of Clinical Nutrition}}, title = {{Associations between food patterns defined by cluster analysis and colorectal cancer incidence in the NIH-AARP diet and health study.}}, url = {{http://dx.doi.org/10.1038/ejcn.2008.40}}, doi = {{10.1038/ejcn.2008.40}}, volume = {{63}}, year = {{2009}}, }