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Long-term testosterone stimulation induces hyperplasia in the guinea-pig prostate.

Acosta, Stefan LU ; Dizeyi, Nishtman LU ; Feinstein, R; Pierzynowski, Stefan LU and Abrahamsson, Per-Anders LU (2004) In Prostate Cancer and Prostatic Diseases 7(3). p.227-231
Abstract
The relation between supraphysiologic circulating testosterone levels and prostatic diseases is unclear and difficult to study in men. Animal models may be advantageous. Based on a pilot study, testosterone enantate 50 mg (n=12) or 25 mg (n=12) was administered to guinea-pigs intramuscularly every 3 weeks, for either 7 or 14 months. The histopathology of the prostate was described. Epithelial hyperplasia was found in 14/21 animals receiving testosterone and in 7/12 very old animals, but no such changes were found in the sham or castrated animals. Testosterone stimulation seems to induce epithelial hyperplasia, but not cancer, in the guinea-pig prostate.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Prostate Cancer and Prostatic Diseases
volume
7
issue
3
pages
227 - 231
publisher
Nature Publishing Group
external identifiers
  • pmid:15289812
  • wos:000224124000011
  • scopus:16644389268
ISSN
1476-5608
DOI
10.1038/sj.pcan.4500744
language
English
LU publication?
yes
id
803b9a23-c043-4993-b577-4f5441db40cf (old id 126906)
date added to LUP
2007-07-09 13:18:29
date last changed
2017-01-01 04:47:42
@article{803b9a23-c043-4993-b577-4f5441db40cf,
  abstract     = {The relation between supraphysiologic circulating testosterone levels and prostatic diseases is unclear and difficult to study in men. Animal models may be advantageous. Based on a pilot study, testosterone enantate 50 mg (n=12) or 25 mg (n=12) was administered to guinea-pigs intramuscularly every 3 weeks, for either 7 or 14 months. The histopathology of the prostate was described. Epithelial hyperplasia was found in 14/21 animals receiving testosterone and in 7/12 very old animals, but no such changes were found in the sham or castrated animals. Testosterone stimulation seems to induce epithelial hyperplasia, but not cancer, in the guinea-pig prostate.},
  author       = {Acosta, Stefan and Dizeyi, Nishtman and Feinstein, R and Pierzynowski, Stefan and Abrahamsson, Per-Anders},
  issn         = {1476-5608},
  language     = {eng},
  number       = {3},
  pages        = {227--231},
  publisher    = {Nature Publishing Group},
  series       = {Prostate Cancer and Prostatic Diseases},
  title        = {Long-term testosterone stimulation induces hyperplasia in the guinea-pig prostate.},
  url          = {http://dx.doi.org/10.1038/sj.pcan.4500744},
  volume       = {7},
  year         = {2004},
}