Long-term testosterone stimulation induces hyperplasia in the guinea-pig prostate.
(2004) In Prostate Cancer and Prostatic Diseases 7(3). p.227-231- Abstract
- The relation between supraphysiologic circulating testosterone levels and prostatic diseases is unclear and difficult to study in men. Animal models may be advantageous. Based on a pilot study, testosterone enantate 50 mg (n=12) or 25 mg (n=12) was administered to guinea-pigs intramuscularly every 3 weeks, for either 7 or 14 months. The histopathology of the prostate was described. Epithelial hyperplasia was found in 14/21 animals receiving testosterone and in 7/12 very old animals, but no such changes were found in the sham or castrated animals. Testosterone stimulation seems to induce epithelial hyperplasia, but not cancer, in the guinea-pig prostate.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/126906
- author
- Acosta, Stefan LU ; Dizeyi, Nishtman LU ; Feinstein, R ; Pierzynowski, Stefan LU and Abrahamsson, Per-Anders LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Prostate Cancer and Prostatic Diseases
- volume
- 7
- issue
- 3
- pages
- 227 - 231
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:15289812
- wos:000224124000011
- scopus:16644389268
- ISSN
- 1476-5608
- DOI
- 10.1038/sj.pcan.4500744
- language
- English
- LU publication?
- yes
- id
- 803b9a23-c043-4993-b577-4f5441db40cf (old id 126906)
- date added to LUP
- 2016-04-01 12:03:25
- date last changed
- 2022-01-26 22:07:27
@article{803b9a23-c043-4993-b577-4f5441db40cf, abstract = {{The relation between supraphysiologic circulating testosterone levels and prostatic diseases is unclear and difficult to study in men. Animal models may be advantageous. Based on a pilot study, testosterone enantate 50 mg (n=12) or 25 mg (n=12) was administered to guinea-pigs intramuscularly every 3 weeks, for either 7 or 14 months. The histopathology of the prostate was described. Epithelial hyperplasia was found in 14/21 animals receiving testosterone and in 7/12 very old animals, but no such changes were found in the sham or castrated animals. Testosterone stimulation seems to induce epithelial hyperplasia, but not cancer, in the guinea-pig prostate.}}, author = {{Acosta, Stefan and Dizeyi, Nishtman and Feinstein, R and Pierzynowski, Stefan and Abrahamsson, Per-Anders}}, issn = {{1476-5608}}, language = {{eng}}, number = {{3}}, pages = {{227--231}}, publisher = {{Nature Publishing Group}}, series = {{Prostate Cancer and Prostatic Diseases}}, title = {{Long-term testosterone stimulation induces hyperplasia in the guinea-pig prostate.}}, url = {{https://lup.lub.lu.se/search/files/2762340/624071.pdf}}, doi = {{10.1038/sj.pcan.4500744}}, volume = {{7}}, year = {{2004}}, }