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Improved sensibility of the foot after temporary cutaneous anesthesia of the lower leg.

Rosén, Birgitta LU ; Björkman, Anders LU ; Weibull, Andreas LU ; Svensson, Jonas LU and Lundborg, Göran LU (2009) In NeuroReport 20. p.37-41
Abstract
Cutaneous anesthesia (EMLA_cream) of the forearm results in rapid improvement of hand sensibility, and here we applied this concept in the lower extremity. This double-blind study with 40 volunteers randomized to cutaneous application of anesthetic cream to the lower leg showed a significant improvement 2 h after treatment in touch thresholds in the EMLA group as compared with the placebo group. In 12 volunteers, fMRI examination was performed before and after treatment. Improvement was not associated with a visible cortical expansion of the cortical foot area. This novel finding may have considerable therapeutic potential in the treatment of foot sensibility disturbances in various neuropathies, such as diabetic neuropathy.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
NeuroReport
volume
20
pages
37 - 41
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000262208800008
  • pmid:19033877
  • scopus:58149236787
ISSN
1473-558X
DOI
10.1097/WNR.0b013e32831b4486
language
English
LU publication?
yes
id
422f0230-cc64-451e-a6e1-1bada4ffd2d9 (old id 1271112)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19033877?dopt=Abstract
date added to LUP
2008-12-03 13:54:57
date last changed
2017-10-22 04:54:32
@article{422f0230-cc64-451e-a6e1-1bada4ffd2d9,
  abstract     = {Cutaneous anesthesia (EMLA_cream) of the forearm results in rapid improvement of hand sensibility, and here we applied this concept in the lower extremity. This double-blind study with 40 volunteers randomized to cutaneous application of anesthetic cream to the lower leg showed a significant improvement 2 h after treatment in touch thresholds in the EMLA group as compared with the placebo group. In 12 volunteers, fMRI examination was performed before and after treatment. Improvement was not associated with a visible cortical expansion of the cortical foot area. This novel finding may have considerable therapeutic potential in the treatment of foot sensibility disturbances in various neuropathies, such as diabetic neuropathy.},
  author       = {Rosén, Birgitta and Björkman, Anders and Weibull, Andreas and Svensson, Jonas and Lundborg, Göran},
  issn         = {1473-558X},
  language     = {eng},
  pages        = {37--41},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {Improved sensibility of the foot after temporary cutaneous anesthesia of the lower leg.},
  url          = {http://dx.doi.org/10.1097/WNR.0b013e32831b4486},
  volume       = {20},
  year         = {2009},
}