Small intestinal CD103(+) dendritic cells display unique functional properties that are conserved between mice and humans
(2008) In Journal of Experimental Medicine 205(9). p.2139-2149- Abstract
- A functionally distinct subset of CD103(+) dendritic cells (DCs) has recently been identified in murine mesenteric lymph nodes (MLN) that induces enhanced FoxP3(+) T cell differentiation, retinoic acid receptor signaling, and gut-homing receptor (CCR9 and alpha 4 beta 7) expression in responding T cells. We show that this function is specific to small intestinal lamina propria (SI-LP) and MLN CD103(+) DCs. CD103(+) SI-LP DCs appeared to derive from circulating DC precursors that continually seed the SI- LP. BrdU pulse-chase experiments suggested that most CD103(+) DCs do not derive from a CD103(-) SI- LP DC intermediate. The majority of CD103(+) MLN DCs appear to represent a tissue- derived migratory population that plays a central role in... (More)
- A functionally distinct subset of CD103(+) dendritic cells (DCs) has recently been identified in murine mesenteric lymph nodes (MLN) that induces enhanced FoxP3(+) T cell differentiation, retinoic acid receptor signaling, and gut-homing receptor (CCR9 and alpha 4 beta 7) expression in responding T cells. We show that this function is specific to small intestinal lamina propria (SI-LP) and MLN CD103(+) DCs. CD103(+) SI-LP DCs appeared to derive from circulating DC precursors that continually seed the SI- LP. BrdU pulse-chase experiments suggested that most CD103(+) DCs do not derive from a CD103(-) SI- LP DC intermediate. The majority of CD103(+) MLN DCs appear to represent a tissue- derived migratory population that plays a central role in presenting orally derived soluble antigen to CD8(+) and CD4(+) T cells. In contrast, most CD103(+) MLN DCs appear to derive from blood precursors, and these cells could proliferate within the MLN and present systemic soluble antigen. Critically, CD103(+) DCs with similar phenotype and functional properties were present in human MLN, and their selective ability to induce CCR9 was maintained by CD103(+) MLN DCs isolated from SB Crohn ' s patients. Thus, small intestinal CD103(+) DCs represent a potential novel target for regulating human intestinal infl ammatory responses. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1286676
- author
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Experimental Medicine
- volume
- 205
- issue
- 9
- pages
- 2139 - 2149
- publisher
- Rockefeller University Press
- external identifiers
-
- wos:000259656300018
- pmid:18710932
- scopus:51049092467
- pmid:18710932
- ISSN
- 1540-9538
- DOI
- 10.1084/jem.20080414
- language
- English
- LU publication?
- yes
- id
- 6e0287f1-325e-4156-8b9c-0868c99c10ac (old id 1286676)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18710932?dopt=Abstract
- date added to LUP
- 2016-04-01 12:22:53
- date last changed
- 2022-04-21 06:37:54
@article{6e0287f1-325e-4156-8b9c-0868c99c10ac, abstract = {{A functionally distinct subset of CD103(+) dendritic cells (DCs) has recently been identified in murine mesenteric lymph nodes (MLN) that induces enhanced FoxP3(+) T cell differentiation, retinoic acid receptor signaling, and gut-homing receptor (CCR9 and alpha 4 beta 7) expression in responding T cells. We show that this function is specific to small intestinal lamina propria (SI-LP) and MLN CD103(+) DCs. CD103(+) SI-LP DCs appeared to derive from circulating DC precursors that continually seed the SI- LP. BrdU pulse-chase experiments suggested that most CD103(+) DCs do not derive from a CD103(-) SI- LP DC intermediate. The majority of CD103(+) MLN DCs appear to represent a tissue- derived migratory population that plays a central role in presenting orally derived soluble antigen to CD8(+) and CD4(+) T cells. In contrast, most CD103(+) MLN DCs appear to derive from blood precursors, and these cells could proliferate within the MLN and present systemic soluble antigen. Critically, CD103(+) DCs with similar phenotype and functional properties were present in human MLN, and their selective ability to induce CCR9 was maintained by CD103(+) MLN DCs isolated from SB Crohn ' s patients. Thus, small intestinal CD103(+) DCs represent a potential novel target for regulating human intestinal infl ammatory responses.}}, author = {{Jaensson Gyllenbäck, Elin and Uronen-Hansson, Heli and Pabst, Oliver and Eksteen, Bertus and Tian, Jiong and Coombes, Janine L. and Berg, Pia-Lena and Davidsson, Thomas and Powrie, Fiona and Johansson Lindbom, Bengt and Agace, William}}, issn = {{1540-9538}}, language = {{eng}}, number = {{9}}, pages = {{2139--2149}}, publisher = {{Rockefeller University Press}}, series = {{Journal of Experimental Medicine}}, title = {{Small intestinal CD103(+) dendritic cells display unique functional properties that are conserved between mice and humans}}, url = {{http://dx.doi.org/10.1084/jem.20080414}}, doi = {{10.1084/jem.20080414}}, volume = {{205}}, year = {{2008}}, }