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Small intestinal CD103(+) dendritic cells display unique functional properties that are conserved between mice and humans

Jaensson Gyllenbäck, Elin LU ; Uronen-Hansson, Heli LU ; Pabst, Oliver; Eksteen, Bertus; Tian, Jiong; Coombes, Janine L.; Berg, Pia-Lena; Davidsson, Thomas LU ; Powrie, Fiona and Johansson Lindbom, Bengt LU , et al. (2008) In Journal of Experimental Medicine 205(9). p.2139-2149
Abstract
A functionally distinct subset of CD103(+) dendritic cells (DCs) has recently been identified in murine mesenteric lymph nodes (MLN) that induces enhanced FoxP3(+) T cell differentiation, retinoic acid receptor signaling, and gut-homing receptor (CCR9 and alpha 4 beta 7) expression in responding T cells. We show that this function is specific to small intestinal lamina propria (SI-LP) and MLN CD103(+) DCs. CD103(+) SI-LP DCs appeared to derive from circulating DC precursors that continually seed the SI- LP. BrdU pulse-chase experiments suggested that most CD103(+) DCs do not derive from a CD103(-) SI- LP DC intermediate. The majority of CD103(+) MLN DCs appear to represent a tissue- derived migratory population that plays a central role in... (More)
A functionally distinct subset of CD103(+) dendritic cells (DCs) has recently been identified in murine mesenteric lymph nodes (MLN) that induces enhanced FoxP3(+) T cell differentiation, retinoic acid receptor signaling, and gut-homing receptor (CCR9 and alpha 4 beta 7) expression in responding T cells. We show that this function is specific to small intestinal lamina propria (SI-LP) and MLN CD103(+) DCs. CD103(+) SI-LP DCs appeared to derive from circulating DC precursors that continually seed the SI- LP. BrdU pulse-chase experiments suggested that most CD103(+) DCs do not derive from a CD103(-) SI- LP DC intermediate. The majority of CD103(+) MLN DCs appear to represent a tissue- derived migratory population that plays a central role in presenting orally derived soluble antigen to CD8(+) and CD4(+) T cells. In contrast, most CD103(+) MLN DCs appear to derive from blood precursors, and these cells could proliferate within the MLN and present systemic soluble antigen. Critically, CD103(+) DCs with similar phenotype and functional properties were present in human MLN, and their selective ability to induce CCR9 was maintained by CD103(+) MLN DCs isolated from SB Crohn ' s patients. Thus, small intestinal CD103(+) DCs represent a potential novel target for regulating human intestinal infl ammatory responses. (Less)
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Contribution to journal
publication status
published
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in
Journal of Experimental Medicine
volume
205
issue
9
pages
2139 - 2149
publisher
Rockefeller University Press
external identifiers
  • wos:000259656300018
  • pmid:18710932
  • scopus:51049092467
ISSN
1540-9538
DOI
10.1084/jem.20080414
language
English
LU publication?
yes
id
6e0287f1-325e-4156-8b9c-0868c99c10ac (old id 1286676)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18710932?dopt=Abstract
date added to LUP
2009-01-29 15:58:40
date last changed
2017-11-05 03:44:38
@article{6e0287f1-325e-4156-8b9c-0868c99c10ac,
  abstract     = {A functionally distinct subset of CD103(+) dendritic cells (DCs) has recently been identified in murine mesenteric lymph nodes (MLN) that induces enhanced FoxP3(+) T cell differentiation, retinoic acid receptor signaling, and gut-homing receptor (CCR9 and alpha 4 beta 7) expression in responding T cells. We show that this function is specific to small intestinal lamina propria (SI-LP) and MLN CD103(+) DCs. CD103(+) SI-LP DCs appeared to derive from circulating DC precursors that continually seed the SI- LP. BrdU pulse-chase experiments suggested that most CD103(+) DCs do not derive from a CD103(-) SI- LP DC intermediate. The majority of CD103(+) MLN DCs appear to represent a tissue- derived migratory population that plays a central role in presenting orally derived soluble antigen to CD8(+) and CD4(+) T cells. In contrast, most CD103(+) MLN DCs appear to derive from blood precursors, and these cells could proliferate within the MLN and present systemic soluble antigen. Critically, CD103(+) DCs with similar phenotype and functional properties were present in human MLN, and their selective ability to induce CCR9 was maintained by CD103(+) MLN DCs isolated from SB Crohn ' s patients. Thus, small intestinal CD103(+) DCs represent a potential novel target for regulating human intestinal infl ammatory responses.},
  author       = {Jaensson Gyllenbäck, Elin and Uronen-Hansson, Heli and Pabst, Oliver and Eksteen, Bertus and Tian, Jiong and Coombes, Janine L. and Berg, Pia-Lena and Davidsson, Thomas and Powrie, Fiona and Johansson Lindbom, Bengt and Agace, William},
  issn         = {1540-9538},
  language     = {eng},
  number       = {9},
  pages        = {2139--2149},
  publisher    = {Rockefeller University Press},
  series       = {Journal of Experimental Medicine},
  title        = {Small intestinal CD103(+) dendritic cells display unique functional properties that are conserved between mice and humans},
  url          = {http://dx.doi.org/10.1084/jem.20080414},
  volume       = {205},
  year         = {2008},
}