MiRNA expression in urothelial carcinomas: Important roles of miR-10a, miR-222, miR-125b, miR-7 and miR-452 for tumor stage and metastasis, and frequent homozygous losses of miR-31.
Veerla, Srinivas LU
; Lindgren, David
LU
; Kvist, Anders
LU
; Frigyesi, Attila
LU
; Staaf, Johan
LU
; Persson, Helena
LU
; Liedberg, Fredrik
LU
; Chebil, Gunilla
; Gudjonsson, Sigurdur
LU
and Borg, Åke
LU
, et al.
(2009)
In International Journal of Cancer
124.
p.2236-2242
- Abstract
- We analyzed 34 cases of urothelial carcinomas by miRNA, mRNA and genomic profiling. Unsupervised hierarchical clustering using expression information for 300 miRNAs produced 3 major clusters of tumors corresponding to Ta, T1 and T2-T3 tumors, respectively. A subsequent SAM analysis identified 51 miRNAs that discriminated the 3 pathological subtypes. A score based on the expression levels of the 51 miRNAs, identified muscle invasive tumors with high precision and sensitivity. MiRNAs showing high expression in muscle invasive tumors included miR-222 and miR-125b and in Ta tumors miR-10a. A miRNA signature for FGFR3 mutated cases was also identified with miR-7 as an important member. MiR-31, located in 9p21, was found to be homozygously... (More)
- We analyzed 34 cases of urothelial carcinomas by miRNA, mRNA and genomic profiling. Unsupervised hierarchical clustering using expression information for 300 miRNAs produced 3 major clusters of tumors corresponding to Ta, T1 and T2-T3 tumors, respectively. A subsequent SAM analysis identified 51 miRNAs that discriminated the 3 pathological subtypes. A score based on the expression levels of the 51 miRNAs, identified muscle invasive tumors with high precision and sensitivity. MiRNAs showing high expression in muscle invasive tumors included miR-222 and miR-125b and in Ta tumors miR-10a. A miRNA signature for FGFR3 mutated cases was also identified with miR-7 as an important member. MiR-31, located in 9p21, was found to be homozygously deleted in 3 cases and miR-452 and miR-452* were shown to be over expressed in node positive tumors. In addition, these latter miRNAs were shown to be excellent prognostic markers for death by disease as outcome. The presented data shows that pathological subtypes of urothelial carcinoma show distinct miRNA gene expression signatures. (c) 2009 Wiley-Liss, Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1289875
- author
- Veerla, Srinivas
LU
; Lindgren, David
LU
; Kvist, Anders
LU
; Frigyesi, Attila
LU
; Staaf, Johan
LU
; Persson, Helena
LU
; Liedberg, Fredrik
LU
; Chebil, Gunilla
; Gudjonsson, Sigurdur
LU
and Borg, Åke
LU
, et al. (More)
- Veerla, Srinivas
LU
; Lindgren, David
LU
; Kvist, Anders
LU
; Frigyesi, Attila
LU
; Staaf, Johan
LU
; Persson, Helena
LU
; Liedberg, Fredrik
LU
; Chebil, Gunilla
; Gudjonsson, Sigurdur
LU
; Borg, Åke
LU
; Månsson, Wiking
LU
; Rovira, Carlos
LU
and Höglund, Mattias
LU
(Less)
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Cancer
- volume
- 124
- pages
- 2236 - 2242
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000264647600031
- pmid:19127597
- scopus:63449123568
- pmid:19127597
- ISSN
- 0020-7136
- DOI
- 10.1002/ijc.24183
- language
- English
- LU publication?
- yes
- id
- a2c75ae1-b59f-4a4d-96af-9f18b216b6ff (old id 1289875)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19127597?dopt=Abstract
- date added to LUP
- 2016-04-04 06:58:16
- date last changed
- 2024-02-10 18:18:53
@article{a2c75ae1-b59f-4a4d-96af-9f18b216b6ff,
abstract = {{We analyzed 34 cases of urothelial carcinomas by miRNA, mRNA and genomic profiling. Unsupervised hierarchical clustering using expression information for 300 miRNAs produced 3 major clusters of tumors corresponding to Ta, T1 and T2-T3 tumors, respectively. A subsequent SAM analysis identified 51 miRNAs that discriminated the 3 pathological subtypes. A score based on the expression levels of the 51 miRNAs, identified muscle invasive tumors with high precision and sensitivity. MiRNAs showing high expression in muscle invasive tumors included miR-222 and miR-125b and in Ta tumors miR-10a. A miRNA signature for FGFR3 mutated cases was also identified with miR-7 as an important member. MiR-31, located in 9p21, was found to be homozygously deleted in 3 cases and miR-452 and miR-452* were shown to be over expressed in node positive tumors. In addition, these latter miRNAs were shown to be excellent prognostic markers for death by disease as outcome. The presented data shows that pathological subtypes of urothelial carcinoma show distinct miRNA gene expression signatures. (c) 2009 Wiley-Liss, Inc.}},
author = {{Veerla, Srinivas and Lindgren, David and Kvist, Anders and Frigyesi, Attila and Staaf, Johan and Persson, Helena and Liedberg, Fredrik and Chebil, Gunilla and Gudjonsson, Sigurdur and Borg, Åke and Månsson, Wiking and Rovira, Carlos and Höglund, Mattias}},
issn = {{0020-7136}},
language = {{eng}},
pages = {{2236--2242}},
publisher = {{John Wiley & Sons Inc.}},
series = {{International Journal of Cancer}},
title = {{MiRNA expression in urothelial carcinomas: Important roles of miR-10a, miR-222, miR-125b, miR-7 and miR-452 for tumor stage and metastasis, and frequent homozygous losses of miR-31.}},
url = {{http://dx.doi.org/10.1002/ijc.24183}},
doi = {{10.1002/ijc.24183}},
volume = {{124}},
year = {{2009}},
}