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MiRNA expression in urothelial carcinomas: Important roles of miR-10a, miR-222, miR-125b, miR-7 and miR-452 for tumor stage and metastasis, and frequent homozygous losses of miR-31.

Veerla, Srinivas LU ; Lindgren, David LU ; Kvist, Anders LU ; Frigyesi, Attila LU ; Staaf, Johan LU ; Persson, Helena LU ; Liedberg, Fredrik LU ; Chebil, Gunilla; Gudjonsson, Sigurdur LU and Borg, Åke LU , et al. (2009) In International Journal of Cancer 124. p.2236-2242
Abstract
We analyzed 34 cases of urothelial carcinomas by miRNA, mRNA and genomic profiling. Unsupervised hierarchical clustering using expression information for 300 miRNAs produced 3 major clusters of tumors corresponding to Ta, T1 and T2-T3 tumors, respectively. A subsequent SAM analysis identified 51 miRNAs that discriminated the 3 pathological subtypes. A score based on the expression levels of the 51 miRNAs, identified muscle invasive tumors with high precision and sensitivity. MiRNAs showing high expression in muscle invasive tumors included miR-222 and miR-125b and in Ta tumors miR-10a. A miRNA signature for FGFR3 mutated cases was also identified with miR-7 as an important member. MiR-31, located in 9p21, was found to be homozygously... (More)
We analyzed 34 cases of urothelial carcinomas by miRNA, mRNA and genomic profiling. Unsupervised hierarchical clustering using expression information for 300 miRNAs produced 3 major clusters of tumors corresponding to Ta, T1 and T2-T3 tumors, respectively. A subsequent SAM analysis identified 51 miRNAs that discriminated the 3 pathological subtypes. A score based on the expression levels of the 51 miRNAs, identified muscle invasive tumors with high precision and sensitivity. MiRNAs showing high expression in muscle invasive tumors included miR-222 and miR-125b and in Ta tumors miR-10a. A miRNA signature for FGFR3 mutated cases was also identified with miR-7 as an important member. MiR-31, located in 9p21, was found to be homozygously deleted in 3 cases and miR-452 and miR-452* were shown to be over expressed in node positive tumors. In addition, these latter miRNAs were shown to be excellent prognostic markers for death by disease as outcome. The presented data shows that pathological subtypes of urothelial carcinoma show distinct miRNA gene expression signatures. (c) 2009 Wiley-Liss, Inc. (Less)
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published
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International Journal of Cancer
volume
124
pages
2236 - 2242
publisher
John Wiley & Sons
external identifiers
  • wos:000264647600031
  • pmid:19127597
  • scopus:63449123568
ISSN
0020-7136
DOI
10.1002/ijc.24183
language
English
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yes
id
a2c75ae1-b59f-4a4d-96af-9f18b216b6ff (old id 1289875)
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http://www.ncbi.nlm.nih.gov/pubmed/19127597?dopt=Abstract
date added to LUP
2009-02-03 10:17:19
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2017-12-10 04:40:43
@article{a2c75ae1-b59f-4a4d-96af-9f18b216b6ff,
  abstract     = {We analyzed 34 cases of urothelial carcinomas by miRNA, mRNA and genomic profiling. Unsupervised hierarchical clustering using expression information for 300 miRNAs produced 3 major clusters of tumors corresponding to Ta, T1 and T2-T3 tumors, respectively. A subsequent SAM analysis identified 51 miRNAs that discriminated the 3 pathological subtypes. A score based on the expression levels of the 51 miRNAs, identified muscle invasive tumors with high precision and sensitivity. MiRNAs showing high expression in muscle invasive tumors included miR-222 and miR-125b and in Ta tumors miR-10a. A miRNA signature for FGFR3 mutated cases was also identified with miR-7 as an important member. MiR-31, located in 9p21, was found to be homozygously deleted in 3 cases and miR-452 and miR-452* were shown to be over expressed in node positive tumors. In addition, these latter miRNAs were shown to be excellent prognostic markers for death by disease as outcome. The presented data shows that pathological subtypes of urothelial carcinoma show distinct miRNA gene expression signatures. (c) 2009 Wiley-Liss, Inc.},
  author       = {Veerla, Srinivas and Lindgren, David and Kvist, Anders and Frigyesi, Attila and Staaf, Johan and Persson, Helena and Liedberg, Fredrik and Chebil, Gunilla and Gudjonsson, Sigurdur and Borg, Åke and Månsson, Wiking and Rovira, Carlos and Höglund, Mattias},
  issn         = {0020-7136},
  language     = {eng},
  pages        = {2236--2242},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {MiRNA expression in urothelial carcinomas: Important roles of miR-10a, miR-222, miR-125b, miR-7 and miR-452 for tumor stage and metastasis, and frequent homozygous losses of miR-31.},
  url          = {http://dx.doi.org/10.1002/ijc.24183},
  volume       = {124},
  year         = {2009},
}