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Lactoferrin and Cancer Disease Prevention

Rodrigues, Ligia; Teixeira, Jose; Schmitt, Fernando; Paulsson, Marie LU and Lindmark Månsson, Helena LU (2009) In Critical Reviews in Food Science and Nutrition 49(3). p.203-217
Abstract
Lactoferrin (LF) is an iron-binding glycoprotein that is composed of the transferrin family and is predominantly found in the products of the exocrine glands located in the gateways of the digestive, respiratory, and reproductive systems, suggesting a role in the non-specific defence against invading pathogens. Additionally, several physiological roles have been attributed to LF, namely regulation of iron homeostasis, host defence against infection and inflammation, regulation of cellular growth, and differentiation and protection against cancer development and metastasis. These findings have suggested LF's great potential therapeutic use in cancer disease prevention and/or treatment, namely as a chemopreventive agent. This review looks at... (More)
Lactoferrin (LF) is an iron-binding glycoprotein that is composed of the transferrin family and is predominantly found in the products of the exocrine glands located in the gateways of the digestive, respiratory, and reproductive systems, suggesting a role in the non-specific defence against invading pathogens. Additionally, several physiological roles have been attributed to LF, namely regulation of iron homeostasis, host defence against infection and inflammation, regulation of cellular growth, and differentiation and protection against cancer development and metastasis. These findings have suggested LF's great potential therapeutic use in cancer disease prevention and/or treatment, namely as a chemopreventive agent. This review looks at the recent advances in understanding the mechanisms underlying the multifunctional roles of LF and future perspectives on its potential therapeutic applications. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
infection, lactoferrin, chemoprevention, inflammation, cancer
in
Critical Reviews in Food Science and Nutrition
volume
49
issue
3
pages
203 - 217
publisher
Taylor & Francis
external identifiers
  • wos:000261803100001
  • scopus:57749195333
ISSN
1040-8398
DOI
10.1080/10408390701856157
language
English
LU publication?
yes
id
8a0a884d-d4b2-49d8-aaac-5a7cc8cc6086 (old id 1313680)
date added to LUP
2009-03-06 15:44:21
date last changed
2017-12-17 03:29:13
@article{8a0a884d-d4b2-49d8-aaac-5a7cc8cc6086,
  abstract     = {Lactoferrin (LF) is an iron-binding glycoprotein that is composed of the transferrin family and is predominantly found in the products of the exocrine glands located in the gateways of the digestive, respiratory, and reproductive systems, suggesting a role in the non-specific defence against invading pathogens. Additionally, several physiological roles have been attributed to LF, namely regulation of iron homeostasis, host defence against infection and inflammation, regulation of cellular growth, and differentiation and protection against cancer development and metastasis. These findings have suggested LF's great potential therapeutic use in cancer disease prevention and/or treatment, namely as a chemopreventive agent. This review looks at the recent advances in understanding the mechanisms underlying the multifunctional roles of LF and future perspectives on its potential therapeutic applications.},
  author       = {Rodrigues, Ligia and Teixeira, Jose and Schmitt, Fernando and Paulsson, Marie and Lindmark Månsson, Helena},
  issn         = {1040-8398},
  keyword      = {infection,lactoferrin,chemoprevention,inflammation,cancer},
  language     = {eng},
  number       = {3},
  pages        = {203--217},
  publisher    = {Taylor & Francis},
  series       = {Critical Reviews in Food Science and Nutrition},
  title        = {Lactoferrin and Cancer Disease Prevention},
  url          = {http://dx.doi.org/10.1080/10408390701856157},
  volume       = {49},
  year         = {2009},
}