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Model-free arterial spin labelling for cerebral blood flow quantification: introduction of regional arterial input functions identified by factor analysis.

Knutsson, Linda LU ; Bloch, Karin M; Holtås, Stig; Wirestam, Ronnie LU and Ståhlberg, Freddy LU (2008) In Magnetic Resonance Imaging 26(4). p.554-559
Abstract
PURPOSE: To identify regional arterial input functions (AIFs) using factor analysis of dynamic studies (FADS) when quantification of perfusion is performed using model-free arterial spin labelling. MATERIAL AND METHODS: Five healthy volunteers and one patient were examined on a 3-T Philips unit using quantitative STAR labelling of arterial regions (QUASAR). Two sets of images were retrieved, one where the arterial signal had been crushed and another where it was retained. FADS was applied to the arterial signal curves to acquire the AIFs. Perfusion maps were obtained using block-circulant SVD deconvolution and regional AIFs obtained by FADS. In the volunteers, the ASL experiment was repeated within 24 h. The patient was also examined using... (More)
PURPOSE: To identify regional arterial input functions (AIFs) using factor analysis of dynamic studies (FADS) when quantification of perfusion is performed using model-free arterial spin labelling. MATERIAL AND METHODS: Five healthy volunteers and one patient were examined on a 3-T Philips unit using quantitative STAR labelling of arterial regions (QUASAR). Two sets of images were retrieved, one where the arterial signal had been crushed and another where it was retained. FADS was applied to the arterial signal curves to acquire the AIFs. Perfusion maps were obtained using block-circulant SVD deconvolution and regional AIFs obtained by FADS. In the volunteers, the ASL experiment was repeated within 24 h. The patient was also examined using dynamic susceptibility contrast MRI. RESULTS: In the healthy volunteers, CBF was 64+/-10 ml/[min 100 g] (mean+/-S.D.) in GM and 24+/-4 ml/[min 100 g] in WM, while the mean aBV was 0.94% in GM and 0.25% in WM. DISCUSSION: Good CBF image quality and reasonable quantitative CBF values were obtained using the combined QUASAR/FADS technique. We conclude that FADS may be a useful supplement in the evaluation of ASL data using QUASAR. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Magnetic Resonance Imaging
volume
26
issue
4
pages
554 - 559
publisher
Elsevier
external identifiers
  • pmid:18060721
  • wos:000255299100013
  • scopus:41949102012
ISSN
1873-5894
DOI
10.1016/j.mri.2007.10.006
language
English
LU publication?
yes
id
fd9980f7-82d4-41f2-9094-f89e423b3510 (old id 1314981)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18060721?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
date added to LUP
2009-06-18 11:48:03
date last changed
2017-01-01 04:40:25
@article{fd9980f7-82d4-41f2-9094-f89e423b3510,
  abstract     = {PURPOSE: To identify regional arterial input functions (AIFs) using factor analysis of dynamic studies (FADS) when quantification of perfusion is performed using model-free arterial spin labelling. MATERIAL AND METHODS: Five healthy volunteers and one patient were examined on a 3-T Philips unit using quantitative STAR labelling of arterial regions (QUASAR). Two sets of images were retrieved, one where the arterial signal had been crushed and another where it was retained. FADS was applied to the arterial signal curves to acquire the AIFs. Perfusion maps were obtained using block-circulant SVD deconvolution and regional AIFs obtained by FADS. In the volunteers, the ASL experiment was repeated within 24 h. The patient was also examined using dynamic susceptibility contrast MRI. RESULTS: In the healthy volunteers, CBF was 64+/-10 ml/[min 100 g] (mean+/-S.D.) in GM and 24+/-4 ml/[min 100 g] in WM, while the mean aBV was 0.94% in GM and 0.25% in WM. DISCUSSION: Good CBF image quality and reasonable quantitative CBF values were obtained using the combined QUASAR/FADS technique. We conclude that FADS may be a useful supplement in the evaluation of ASL data using QUASAR.},
  author       = {Knutsson, Linda and Bloch, Karin M and Holtås, Stig and Wirestam, Ronnie and Ståhlberg, Freddy},
  issn         = {1873-5894},
  language     = {eng},
  number       = {4},
  pages        = {554--559},
  publisher    = {Elsevier},
  series       = {Magnetic Resonance Imaging},
  title        = {Model-free arterial spin labelling for cerebral blood flow quantification: introduction of regional arterial input functions identified by factor analysis.},
  url          = {http://dx.doi.org/10.1016/j.mri.2007.10.006},
  volume       = {26},
  year         = {2008},
}