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High ID2 protein expression correlates with a favourable prognosis in patients with primary breast cancer and reduces cellular invasiveness of breast cancer cells.

Stighall, Maria LU ; Manetopoulos, Christina LU ; Axelson, Håkan LU and Landberg, Göran LU (2005) In International Journal of Cancer 115(3). p.403-411
Abstract
ID proteins have been implicated in the regulation of cell proliferation and differentiation in various cell types during normal development as well as in the formation of cancer. Our aim was to delineate the expression of ID2 by immunohistochemistry in primary breast cancer in order to detect potential associations with cell cycle regulatory proteins and/or clinicopathologic parameters. We further overexpressed ID2 in a breast cancer cell line to elaborate potential effects on proliferation and invasiveness. We observed large variations in ID2 expression in primary breast cancer, and the protein was localised to both the nucleus and cytoplasm. Interestingly, a high cytoplasmic ID2 protein level correlated with a favourable prognosis.... (More)
ID proteins have been implicated in the regulation of cell proliferation and differentiation in various cell types during normal development as well as in the formation of cancer. Our aim was to delineate the expression of ID2 by immunohistochemistry in primary breast cancer in order to detect potential associations with cell cycle regulatory proteins and/or clinicopathologic parameters. We further overexpressed ID2 in a breast cancer cell line to elaborate potential effects on proliferation and invasiveness. We observed large variations in ID2 expression in primary breast cancer, and the protein was localised to both the nucleus and cytoplasm. Interestingly, a high cytoplasmic ID2 protein level correlated with a favourable prognosis. Overexpressing ID2 in the MDA-MB-468 breast cancer cell line generated a marked cytoplasmic localisation of the protein and reduced the invasive capacity of cells. Modest enhancement of cell proliferation was further detected in ID2-overexpressing cells. In conclusion, ID2 protein expression varies substantially within primary breast tumours and high cytoplasmic levels of ID2 might reflect a less aggressive breast tumour phenotype. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
breast cancer, invasion, proliferation, ID2
in
International Journal of Cancer
volume
115
issue
3
pages
403 - 411
publisher
John Wiley & Sons
external identifiers
  • wos:000229025600010
  • pmid:15688367
  • scopus:18644374754
ISSN
0020-7136
DOI
10.1002/ijc.20875
language
English
LU publication?
yes
id
3160e475-7fa6-4150-ae19-c40cb2766efc (old id 133909)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15688367&dopt=Abstract
date added to LUP
2007-07-27 10:35:59
date last changed
2017-11-12 03:18:40
@article{3160e475-7fa6-4150-ae19-c40cb2766efc,
  abstract     = {ID proteins have been implicated in the regulation of cell proliferation and differentiation in various cell types during normal development as well as in the formation of cancer. Our aim was to delineate the expression of ID2 by immunohistochemistry in primary breast cancer in order to detect potential associations with cell cycle regulatory proteins and/or clinicopathologic parameters. We further overexpressed ID2 in a breast cancer cell line to elaborate potential effects on proliferation and invasiveness. We observed large variations in ID2 expression in primary breast cancer, and the protein was localised to both the nucleus and cytoplasm. Interestingly, a high cytoplasmic ID2 protein level correlated with a favourable prognosis. Overexpressing ID2 in the MDA-MB-468 breast cancer cell line generated a marked cytoplasmic localisation of the protein and reduced the invasive capacity of cells. Modest enhancement of cell proliferation was further detected in ID2-overexpressing cells. In conclusion, ID2 protein expression varies substantially within primary breast tumours and high cytoplasmic levels of ID2 might reflect a less aggressive breast tumour phenotype.},
  author       = {Stighall, Maria and Manetopoulos, Christina and Axelson, Håkan and Landberg, Göran},
  issn         = {0020-7136},
  keyword      = {breast cancer,invasion,proliferation,ID2},
  language     = {eng},
  number       = {3},
  pages        = {403--411},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {High ID2 protein expression correlates with a favourable prognosis in patients with primary breast cancer and reduces cellular invasiveness of breast cancer cells.},
  url          = {http://dx.doi.org/10.1002/ijc.20875},
  volume       = {115},
  year         = {2005},
}