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An elemental diet fed, enteral or parenteral, does not support growth in young pigs with exocrine pancreatic insufficiency.

Rengman, Sofia LU ; Fedkiv, Olexandr LU ; Botermans, Jos; Svendsen, Jörgen; Weström, Björn LU and Pierzynowski, Stefan LU (2009) In Clinical Nutrition 28. p.325-330
Abstract
BACKGROUND: & aims: Young individuals with exocrine pancreatic insufficiency (EPI) show growth reduction that can be reversed by dietary pancreatic enzyme supplementation. Here we investigated whether feeding an elemental diet could replace the growth-promoting effect of enzyme supplementation in EPI pigs. METHODS: Weaned pigs with intact pancreas (control) or pancreatic duct-ligated (EPI pigs) were given a commercial pig feed, a fat-enriched diet, or an elemental diet, intragastrically and intravenously, with or without porcine pancreatin (Creon((R))) supplementation for 1week. RESULTS: Control pigs, irrespective of receiving pig feed or an elemental diet, increased their body weight by 13.4-20.1%, while EPI pigs showed negligible... (More)
BACKGROUND: & aims: Young individuals with exocrine pancreatic insufficiency (EPI) show growth reduction that can be reversed by dietary pancreatic enzyme supplementation. Here we investigated whether feeding an elemental diet could replace the growth-promoting effect of enzyme supplementation in EPI pigs. METHODS: Weaned pigs with intact pancreas (control) or pancreatic duct-ligated (EPI pigs) were given a commercial pig feed, a fat-enriched diet, or an elemental diet, intragastrically and intravenously, with or without porcine pancreatin (Creon((R))) supplementation for 1week. RESULTS: Control pigs, irrespective of receiving pig feed or an elemental diet, increased their body weight by 13.4-20.1%, while EPI pigs showed negligible weight gain. Giving a fat-enriched diet did not improve growth of the EPI pigs. However, if the EPI pigs were supplemented with pancreatin in combination with fat-enriched feed or the elemental diet, i.v., their body weight increased by 16.6 %and 8.5%, respectively. CONCLUSION: Control pigs maintained normal growth, independently of the diet being given in polymeric or elemental form, while EPI pigs showed impaired growth when receiving the same diets without enzyme supplementation. Pancreatic juice and enzyme preparations, in addition to their digestive properties, also appear to affect nutrient assimilation and anabolism in young individuals. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Nutrition
volume
28
pages
325 - 330
publisher
Elsevier
external identifiers
  • wos:000267620400018
  • scopus:67349118728
ISSN
1532-1983
DOI
10.1016/j.clnu.2009.02.010
language
English
LU publication?
yes
id
362f662d-dd65-4ad1-8673-63ffaa2b5651 (old id 1367672)
date added to LUP
2009-04-14 09:41:01
date last changed
2017-09-03 04:15:16
@article{362f662d-dd65-4ad1-8673-63ffaa2b5651,
  abstract     = {BACKGROUND: & aims: Young individuals with exocrine pancreatic insufficiency (EPI) show growth reduction that can be reversed by dietary pancreatic enzyme supplementation. Here we investigated whether feeding an elemental diet could replace the growth-promoting effect of enzyme supplementation in EPI pigs. METHODS: Weaned pigs with intact pancreas (control) or pancreatic duct-ligated (EPI pigs) were given a commercial pig feed, a fat-enriched diet, or an elemental diet, intragastrically and intravenously, with or without porcine pancreatin (Creon((R))) supplementation for 1week. RESULTS: Control pigs, irrespective of receiving pig feed or an elemental diet, increased their body weight by 13.4-20.1%, while EPI pigs showed negligible weight gain. Giving a fat-enriched diet did not improve growth of the EPI pigs. However, if the EPI pigs were supplemented with pancreatin in combination with fat-enriched feed or the elemental diet, i.v., their body weight increased by 16.6 %and 8.5%, respectively. CONCLUSION: Control pigs maintained normal growth, independently of the diet being given in polymeric or elemental form, while EPI pigs showed impaired growth when receiving the same diets without enzyme supplementation. Pancreatic juice and enzyme preparations, in addition to their digestive properties, also appear to affect nutrient assimilation and anabolism in young individuals.},
  author       = {Rengman, Sofia and Fedkiv, Olexandr and Botermans, Jos and Svendsen, Jörgen and Weström, Björn and Pierzynowski, Stefan},
  issn         = {1532-1983},
  language     = {eng},
  pages        = {325--330},
  publisher    = {Elsevier},
  series       = {Clinical Nutrition},
  title        = {An elemental diet fed, enteral or parenteral, does not support growth in young pigs with exocrine pancreatic insufficiency.},
  url          = {http://dx.doi.org/10.1016/j.clnu.2009.02.010},
  volume       = {28},
  year         = {2009},
}