Advanced

Mitochondrial DNA polymorphisms are associated with susceptibility and phenotype of systemic lupus erythematosus.

Jönsen, Andreas LU ; Yu, X; Truedsson, Lennart LU ; Nived, Ola LU ; Sturfelt, Gunnar LU ; Ibrahim, S and Bengtsson, Aa (2009) In Lupus 18(4). p.309-312
Abstract
The objective of this study was to investigate the possible association between mitochondrial DNA polymorphisms and systemic lupus erythematosus (SLE). A cohort from the Department of Rheumatology, Lund University Hospital, Sweden, consisting of 166 unrelated SLE patients was investigated as well as 190 unrelated healthy blood donors. Mean age at SLE diagnosis was 39 years (range 10-83) and mean follow-up time was 16 years (range 1-44). There were 87% women among the lupus patients, and the control group consisted of 98 women and 92 men from the same geographical area and with a similar age and ethnicity. The mtDNA SNP nt16189C was associated with SLE (OR = 1.98, 95% CI 1.04-3.78, P = 0.05). In addition, SNP nt13708A was associated with... (More)
The objective of this study was to investigate the possible association between mitochondrial DNA polymorphisms and systemic lupus erythematosus (SLE). A cohort from the Department of Rheumatology, Lund University Hospital, Sweden, consisting of 166 unrelated SLE patients was investigated as well as 190 unrelated healthy blood donors. Mean age at SLE diagnosis was 39 years (range 10-83) and mean follow-up time was 16 years (range 1-44). There were 87% women among the lupus patients, and the control group consisted of 98 women and 92 men from the same geographical area and with a similar age and ethnicity. The mtDNA SNP nt16189C was associated with SLE (OR = 1.98, 95% CI 1.04-3.78, P = 0.05). In addition, SNP nt13708A was associated with SLE in males (OR = 3.46, 95% CI 1.08-11.1, P = 0.04), although the number of male patients was low. Furthermore, SNP nt10398A was associated with secondary anti-phospholipid syndrome (P = 0.017, OR 8.2, 95% CI 1.1-63). In conclusion, in this study, we have for the first time investigated the possible association between SLE disease and mitochondrial DNA polymorphisms. Altogether, these novel results suggest that mtDNA polymorphisms may be associated with development of SLE and may potentially be of importance in SLE pathogenesis. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Lupus
volume
18
issue
4
pages
309 - 312
publisher
SAGE Publications Ltd
external identifiers
  • wos:000264320100004
  • pmid:19276298
  • scopus:62749122727
ISSN
0961-2033
DOI
10.1177/0961203308097477
language
English
LU publication?
yes
id
635922a2-660e-4830-a9a6-709c66a85c22 (old id 1367882)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19276298?dopt=Abstract
date added to LUP
2009-04-07 16:26:16
date last changed
2017-11-19 04:18:59
@article{635922a2-660e-4830-a9a6-709c66a85c22,
  abstract     = {The objective of this study was to investigate the possible association between mitochondrial DNA polymorphisms and systemic lupus erythematosus (SLE). A cohort from the Department of Rheumatology, Lund University Hospital, Sweden, consisting of 166 unrelated SLE patients was investigated as well as 190 unrelated healthy blood donors. Mean age at SLE diagnosis was 39 years (range 10-83) and mean follow-up time was 16 years (range 1-44). There were 87% women among the lupus patients, and the control group consisted of 98 women and 92 men from the same geographical area and with a similar age and ethnicity. The mtDNA SNP nt16189C was associated with SLE (OR = 1.98, 95% CI 1.04-3.78, P = 0.05). In addition, SNP nt13708A was associated with SLE in males (OR = 3.46, 95% CI 1.08-11.1, P = 0.04), although the number of male patients was low. Furthermore, SNP nt10398A was associated with secondary anti-phospholipid syndrome (P = 0.017, OR 8.2, 95% CI 1.1-63). In conclusion, in this study, we have for the first time investigated the possible association between SLE disease and mitochondrial DNA polymorphisms. Altogether, these novel results suggest that mtDNA polymorphisms may be associated with development of SLE and may potentially be of importance in SLE pathogenesis.},
  author       = {Jönsen, Andreas and Yu, X and Truedsson, Lennart and Nived, Ola and Sturfelt, Gunnar and Ibrahim, S and Bengtsson, Aa},
  issn         = {0961-2033},
  language     = {eng},
  number       = {4},
  pages        = {309--312},
  publisher    = {SAGE Publications Ltd},
  series       = {Lupus},
  title        = {Mitochondrial DNA polymorphisms are associated with susceptibility and phenotype of systemic lupus erythematosus.},
  url          = {http://dx.doi.org/10.1177/0961203308097477},
  volume       = {18},
  year         = {2009},
}