Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke
(2009) In Nature Neuroscience 12(3). p.259-267- Abstract
- Neurons are continuously generated from stem cells in discrete regions in the adult mammalian brain. We found that ependymal cells lining the lateral ventricles were quiescent and did not contribute to adult neurogenesis under normal conditions in mice but instead gave rise to neuroblasts and astrocytes in response to stroke. Ependymal cell quiescence was actively maintained by canonical Notch signaling. Inhibition of this pathway in uninjured animals allowed ependymal cells to enter the cell cycle and produce olfactory bulb neurons, whereas forced Notch signaling was sufficient to block the ependymal cell response to stroke. Ependymal cells were depleted by stroke and failed to self-renew sufficiently to maintain their own population.... (More)
- Neurons are continuously generated from stem cells in discrete regions in the adult mammalian brain. We found that ependymal cells lining the lateral ventricles were quiescent and did not contribute to adult neurogenesis under normal conditions in mice but instead gave rise to neuroblasts and astrocytes in response to stroke. Ependymal cell quiescence was actively maintained by canonical Notch signaling. Inhibition of this pathway in uninjured animals allowed ependymal cells to enter the cell cycle and produce olfactory bulb neurons, whereas forced Notch signaling was sufficient to block the ependymal cell response to stroke. Ependymal cells were depleted by stroke and failed to self-renew sufficiently to maintain their own population. Thus, although ependymal cells act as primary cells in the neural lineage to produce neurons and glial cells after stroke, they do not fulfill defining criteria for stem cells under these conditions and instead serve as a reservoir that is recruited by injury. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1372102
- author
- Carlen, Marie
; Meletis, Konstantinos
; Goritz, Christian
; Darsalia, Vladimer
LU
; Evergren, Emma
; Tanigaki, Kenji
; Amendola, Mario
; Barnabe-Heider, Fanie
; Yeung, Maggie S. Y.
; Naldini, Luigi
; Honjo, Tasuku
; Kokaia, Zaal
LU
; Shupliakov, Oleg
; Cassidy, Robert M.
; Lindvall, Olle
LU
and Frisen, Jonas
(Less) - organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Neuroscience
- volume
- 12
- issue
- 3
- pages
- 259 - 267
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000263577900010
- scopus:60749099023
- pmid:19234458
- ISSN
- 1546-1726
- DOI
- 10.1038/nn.2268
- language
- English
- LU publication?
- yes
- id
- 4e73d8d8-aee6-4a90-ac16-4f2d90df0295 (old id 1372102)
- date added to LUP
- 2016-04-01 14:01:59
- date last changed
- 2022-04-22 01:00:31
@article{4e73d8d8-aee6-4a90-ac16-4f2d90df0295,
abstract = {{Neurons are continuously generated from stem cells in discrete regions in the adult mammalian brain. We found that ependymal cells lining the lateral ventricles were quiescent and did not contribute to adult neurogenesis under normal conditions in mice but instead gave rise to neuroblasts and astrocytes in response to stroke. Ependymal cell quiescence was actively maintained by canonical Notch signaling. Inhibition of this pathway in uninjured animals allowed ependymal cells to enter the cell cycle and produce olfactory bulb neurons, whereas forced Notch signaling was sufficient to block the ependymal cell response to stroke. Ependymal cells were depleted by stroke and failed to self-renew sufficiently to maintain their own population. Thus, although ependymal cells act as primary cells in the neural lineage to produce neurons and glial cells after stroke, they do not fulfill defining criteria for stem cells under these conditions and instead serve as a reservoir that is recruited by injury.}},
author = {{Carlen, Marie and Meletis, Konstantinos and Goritz, Christian and Darsalia, Vladimer and Evergren, Emma and Tanigaki, Kenji and Amendola, Mario and Barnabe-Heider, Fanie and Yeung, Maggie S. Y. and Naldini, Luigi and Honjo, Tasuku and Kokaia, Zaal and Shupliakov, Oleg and Cassidy, Robert M. and Lindvall, Olle and Frisen, Jonas}},
issn = {{1546-1726}},
language = {{eng}},
number = {{3}},
pages = {{259--267}},
publisher = {{Nature Publishing Group}},
series = {{Nature Neuroscience}},
title = {{Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke}},
url = {{http://dx.doi.org/10.1038/nn.2268}},
doi = {{10.1038/nn.2268}},
volume = {{12}},
year = {{2009}},
}