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Expression Of Pten And Shp1, Investigated From Tissue Microarrays In Pediatric Acute Lymphoblastic, Leukemia

Gauffin, Fredrika; Diffner, Eva LU ; Gustafsson, Bertil; Nordgren, Ann; Gjörloff Wingren, Anette LU ; Sander, Birgitta; Persson, Jenny L LU and Gustafsson, Britt (2009) In Pediatric Hematology & Oncology 26(1). p.48-56
Abstract
PTEN and SHP1 are tumor suppressor genes involved in the regulation of cell cycle control and apoptosis. The authors investigated the protein expression of PTEN and SHP1, by immunohistochemistry in tissue microarrays from bone marrow samples in children, diagnosed with acute lymphoblastic leukaemia and nonmalignant controls. PTEN was overexpressed in diagnostic ALL samples, while SHP1 showed a low expression. Both proteins showed a significant difference in expression compared to nonmalignant controls. The roles of PTEN and SHP1 are not well investigated in pediatric leukemia and could in the future play a role as prognostic factors.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
SHP1, tissue microarray, pediatric leukemia, PTEN
in
Pediatric Hematology & Oncology
volume
26
issue
1
pages
48 - 56
publisher
Hemisphere Pub. Corp.
external identifiers
  • wos:000263269000005
  • scopus:61649117545
ISSN
1521-0669
DOI
10.1080/08880010802625530
language
English
LU publication?
yes
id
aafe346c-2383-4369-9e6b-f28879a303d5 (old id 1374842)
date added to LUP
2009-05-08 14:06:24
date last changed
2017-01-08 03:46:01
@article{aafe346c-2383-4369-9e6b-f28879a303d5,
  abstract     = {PTEN and SHP1 are tumor suppressor genes involved in the regulation of cell cycle control and apoptosis. The authors investigated the protein expression of PTEN and SHP1, by immunohistochemistry in tissue microarrays from bone marrow samples in children, diagnosed with acute lymphoblastic leukaemia and nonmalignant controls. PTEN was overexpressed in diagnostic ALL samples, while SHP1 showed a low expression. Both proteins showed a significant difference in expression compared to nonmalignant controls. The roles of PTEN and SHP1 are not well investigated in pediatric leukemia and could in the future play a role as prognostic factors.},
  author       = {Gauffin, Fredrika and Diffner, Eva and Gustafsson, Bertil and Nordgren, Ann and Gjörloff Wingren, Anette and Sander, Birgitta and Persson, Jenny L and Gustafsson, Britt},
  issn         = {1521-0669},
  keyword      = {SHP1,tissue microarray,pediatric leukemia,PTEN},
  language     = {eng},
  number       = {1},
  pages        = {48--56},
  publisher    = {Hemisphere Pub. Corp.},
  series       = {Pediatric Hematology & Oncology},
  title        = {Expression Of Pten And Shp1, Investigated From Tissue Microarrays In Pediatric Acute Lymphoblastic, Leukemia},
  url          = {http://dx.doi.org/10.1080/08880010802625530},
  volume       = {26},
  year         = {2009},
}