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High body mass index is associated with increased risk for osteoarthritis of the first carpometacarpal joint during more than 30 years of follow-up

Rydberg, Mattias LU orcid ; Dahlin, Lars B LU orcid ; Gottsäter, Anders LU ; Nilsson, Peter M LU ; Melander, Olle LU orcid and Zimmerman, Malin LU orcid (2020) In RMD Open 6(3).
Abstract
Introduction Osteoarthritis (OA) of the first carpometacarpal (CMC-1) joint is a common hand disorder with symptoms including pain and weakness of the thumb. Previous studies have associated high BMI with OA of weight-bearing joints, whereas studies regarding non-weight-bearing joints have shown conflicting results. Thus, the aim of this study was to investigate the influence of overweight and obesity on incident OA of the CMC-1 joint.

Method During 1974 to 1992, 33 346 participants aged 26–61 years were included in the population-based cohort Malmö Preventive Project. Endpoint data were retrieved from Swedish national registers until end of 2018. Sex-stratified Cox regression models adjusted for potential confounders were... (More)
Introduction Osteoarthritis (OA) of the first carpometacarpal (CMC-1) joint is a common hand disorder with symptoms including pain and weakness of the thumb. Previous studies have associated high BMI with OA of weight-bearing joints, whereas studies regarding non-weight-bearing joints have shown conflicting results. Thus, the aim of this study was to investigate the influence of overweight and obesity on incident OA of the CMC-1 joint.

Method During 1974 to 1992, 33 346 participants aged 26–61 years were included in the population-based cohort Malmö Preventive Project. Endpoint data were retrieved from Swedish national registers until end of 2018. Sex-stratified Cox regression models adjusted for potential confounders were calculated using BMI as a continuous variable and stratified for normal weight, overweight and obesity.

Results Median follow-up was 36 years for men and 32 years for women. A one-unit increment of BMI was independently associated with incident OA of the CMC-1 joint in men (HR 1.12; 95% CI 1.09 to 1.15, p<0.001) and women (HR 1.05; 95% CI 1.03 to 1.08, p<0.001). Stratifying for BMI groups, obesity was independently associated with OA of the CMC-1 joint in men (HR 3.57; 95% CI 2.68 to 4.77, p<0.001) and women (HR 1.98; 95% CI 1.44 to 2.73, p<0.001).

Conclusion High BMI and obesity are major risk factors for OA of the CMC-1 joint. The association was stronger among men but could be demonstrated also among women. Future studies are warranted to clarify underlying pathophysiological mechanisms for this association, enabling identification of potential therapeutic targets related to obesity in order to prevent the development of OA of the CMC-1 joint. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
RMD Open
volume
6
issue
3
article number
e001368
publisher
BMJ Publishing Group
external identifiers
  • pmid:33109634
  • scopus:85094831776
ISSN
2056-5933
DOI
10.1136/rmdopen-2020-001368
language
English
LU publication?
yes
id
137c1ab5-5876-4210-8ac3-23510bd47d4f
date added to LUP
2020-11-03 07:08:27
date last changed
2024-01-02 19:32:11
@article{137c1ab5-5876-4210-8ac3-23510bd47d4f,
  abstract     = {{Introduction Osteoarthritis (OA) of the first carpometacarpal (CMC-1) joint is a common hand disorder with symptoms including pain and weakness of the thumb. Previous studies have associated high BMI with OA of weight-bearing joints, whereas studies regarding non-weight-bearing joints have shown conflicting results. Thus, the aim of this study was to investigate the influence of overweight and obesity on incident OA of the CMC-1 joint.<br>
<br>
Method During 1974 to 1992, 33 346 participants aged 26–61 years were included in the population-based cohort Malmö Preventive Project. Endpoint data were retrieved from Swedish national registers until end of 2018. Sex-stratified Cox regression models adjusted for potential confounders were calculated using BMI as a continuous variable and stratified for normal weight, overweight and obesity.<br>
<br>
Results Median follow-up was 36 years for men and 32 years for women. A one-unit increment of BMI was independently associated with incident OA of the CMC-1 joint in men (HR 1.12; 95% CI 1.09 to 1.15, p&lt;0.001) and women (HR 1.05; 95% CI 1.03 to 1.08, p&lt;0.001). Stratifying for BMI groups, obesity was independently associated with OA of the CMC-1 joint in men (HR 3.57; 95% CI 2.68 to 4.77, p&lt;0.001) and women (HR 1.98; 95% CI 1.44 to 2.73, p&lt;0.001).<br>
<br>
Conclusion High BMI and obesity are major risk factors for OA of the CMC-1 joint. The association was stronger among men but could be demonstrated also among women. Future studies are warranted to clarify underlying pathophysiological mechanisms for this association, enabling identification of potential therapeutic targets related to obesity in order to prevent the development of OA of the CMC-1 joint.}},
  author       = {{Rydberg, Mattias and Dahlin, Lars B and Gottsäter, Anders and Nilsson, Peter M and Melander, Olle and Zimmerman, Malin}},
  issn         = {{2056-5933}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{3}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{RMD Open}},
  title        = {{High body mass index is associated with increased risk for osteoarthritis of the first carpometacarpal joint during more than 30 years of follow-up}},
  url          = {{http://dx.doi.org/10.1136/rmdopen-2020-001368}},
  doi          = {{10.1136/rmdopen-2020-001368}},
  volume       = {{6}},
  year         = {{2020}},
}