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Exposure to beta-carbolines norharman and harman

Pfau, W and Skog, Kerstin LU (2004) In Journal of Chromatography. B 802(1). p.115-126
Abstract
The aromatic beta-carbolines norharman and harman have been implicated in a number of human diseases including Parkinson's disease, tremor, addiction and cancer. It has been shown that these compounds are normal body constituents formed endogenously but external sources have been identified. Here, we summarise literature data on levels of norharman and harman in fried meat and fish, meat extracts, alcoholic drinks, and coffee brews. Other sources include edible and medicinal plants but tobacco smoke has been identified as a major source. Exposure levels from these different dietary sources are estimated to a maximum of 4 mug norharman per kg body weight (bw) per day and 1 mug harman per kg bw per day. Exposure via tobacco smoke depends on... (More)
The aromatic beta-carbolines norharman and harman have been implicated in a number of human diseases including Parkinson's disease, tremor, addiction and cancer. It has been shown that these compounds are normal body constituents formed endogenously but external sources have been identified. Here, we summarise literature data on levels of norharman and harman in fried meat and fish, meat extracts, alcoholic drinks, and coffee brews. Other sources include edible and medicinal plants but tobacco smoke has been identified as a major source. Exposure levels from these different dietary sources are estimated to a maximum of 4 mug norharman per kg body weight (bw) per day and 1 mug harman per kg bw per day. Exposure via tobacco smoke depends on smoking habits and type of cigarettes but can be estimated to 1.1 mug/kg bw for norharman and 0.6 mug/kg bw for harman per package of cigarettes smoked. Studies on toxicokinetics indicate that inhalative exposure leads to a rapid increase in plasma levels and high bioavailability of norharman and harman. Oral bioavailability is lower but there are indications that sublingual absorption may increase dietary uptake of beta-carbolines. Endogenous formation can be estimated to be 50-100 ng/kg bw per day for norharman and about 20 ng/kg bw per day for harman but these rates may increase with high intake of precursors. Biomarker studies on plasma levels of beta-carbolines reported on elevated levels of norharman, harman or both in diseased patients, alcoholics and following tobacco smoking or consumption of beta-carboline-containing food. Cigarette smoking has been identified as major influence but dietary exposure may contribute to exposure. (C) 2003 Elsevier B.V. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Reviews, β-Carbolines, Norharman, Harman
in
Journal of Chromatography. B
volume
802
issue
1
pages
115 - 126
publisher
Elsevier
external identifiers
  • wos:000189248700014
  • pmid:15036003
  • scopus:1242351299
ISSN
1873-376X
DOI
10.1016/j.jchromb.2003.10.044
language
English
LU publication?
yes
id
ec7f12b4-a00c-4076-9d7c-8a6173540173 (old id 138644)
date added to LUP
2007-07-18 11:24:57
date last changed
2017-11-05 03:29:23
@article{ec7f12b4-a00c-4076-9d7c-8a6173540173,
  abstract     = {The aromatic beta-carbolines norharman and harman have been implicated in a number of human diseases including Parkinson's disease, tremor, addiction and cancer. It has been shown that these compounds are normal body constituents formed endogenously but external sources have been identified. Here, we summarise literature data on levels of norharman and harman in fried meat and fish, meat extracts, alcoholic drinks, and coffee brews. Other sources include edible and medicinal plants but tobacco smoke has been identified as a major source. Exposure levels from these different dietary sources are estimated to a maximum of 4 mug norharman per kg body weight (bw) per day and 1 mug harman per kg bw per day. Exposure via tobacco smoke depends on smoking habits and type of cigarettes but can be estimated to 1.1 mug/kg bw for norharman and 0.6 mug/kg bw for harman per package of cigarettes smoked. Studies on toxicokinetics indicate that inhalative exposure leads to a rapid increase in plasma levels and high bioavailability of norharman and harman. Oral bioavailability is lower but there are indications that sublingual absorption may increase dietary uptake of beta-carbolines. Endogenous formation can be estimated to be 50-100 ng/kg bw per day for norharman and about 20 ng/kg bw per day for harman but these rates may increase with high intake of precursors. Biomarker studies on plasma levels of beta-carbolines reported on elevated levels of norharman, harman or both in diseased patients, alcoholics and following tobacco smoking or consumption of beta-carboline-containing food. Cigarette smoking has been identified as major influence but dietary exposure may contribute to exposure. (C) 2003 Elsevier B.V. All rights reserved.},
  author       = {Pfau, W and Skog, Kerstin},
  issn         = {1873-376X},
  keyword      = {Reviews,β-Carbolines,Norharman,Harman},
  language     = {eng},
  number       = {1},
  pages        = {115--126},
  publisher    = {Elsevier},
  series       = {Journal of Chromatography. B},
  title        = {Exposure to beta-carbolines norharman and harman},
  url          = {http://dx.doi.org/10.1016/j.jchromb.2003.10.044},
  volume       = {802},
  year         = {2004},
}