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Long-term retention of neurotoxic beta-carbolines in brain neuromelanin

Ostergren, A; Annas, A; Skog, Kerstin LU ; Lindquist, N G and Brittebo, E B (2004) In Journal of Neural Transmission 111(2). p.141-157
Abstract
beta-Carbolines show structural resemblance to the neurotoxic N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and are metabolized to mitochondrial toxicants. Humans are continuously exposed to low levels of beta-carbolines through cooked food, coffee, alcoholic beverages and tobacco smoke. beta-Carbolines have previously been detected in higher levels in the pigmented substantia nigra than in the cortex of humans. The distribution of H-3-labelled harman and norharman in the brain of pigmented and albino mice and in frogs (a species having neuromelanin) was studied by tape-section and light-microscopic autoradiography. Furthermore, the binding of these beta-carbolines to dopamine-melanin and melanin granules from Sepia officinalis was... (More)
beta-Carbolines show structural resemblance to the neurotoxic N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and are metabolized to mitochondrial toxicants. Humans are continuously exposed to low levels of beta-carbolines through cooked food, coffee, alcoholic beverages and tobacco smoke. beta-Carbolines have previously been detected in higher levels in the pigmented substantia nigra than in the cortex of humans. The distribution of H-3-labelled harman and norharman in the brain of pigmented and albino mice and in frogs (a species having neuromelanin) was studied by tape-section and light-microscopic autoradiography. Furthermore, the binding of these beta-carbolines to dopamine-melanin and melanin granules from Sepia officinalis was examined. The results revealed a high affinity binding to melanin and a long-term retention (up to 30 days) in pigmented tissues, including neuromelanin-containing neurons of frogs after a single injection. The role of long-term exposure to food-related beta-carbolines and a retention of these compounds in pigment-containing neurons in the induction of idiopathic Parkinson's disease should be further considered. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
b-Carbolines, parkinsonism, neuromelanin, harman, norharman, Parkinson’s disease, dopamine–melanin, Sepia officinalis
in
Journal of Neural Transmission
volume
111
issue
2
pages
141 - 157
publisher
Springer
external identifiers
  • pmid:14767717
  • wos:000188839000003
  • scopus:1442265714
ISSN
0300-9564
DOI
10.1007/s00702-003-0080-0
language
English
LU publication?
yes
id
9223e463-6a09-4b5a-b992-27b3a8910d24 (old id 138648)
date added to LUP
2007-07-18 10:56:41
date last changed
2017-09-24 04:34:48
@article{9223e463-6a09-4b5a-b992-27b3a8910d24,
  abstract     = {beta-Carbolines show structural resemblance to the neurotoxic N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and are metabolized to mitochondrial toxicants. Humans are continuously exposed to low levels of beta-carbolines through cooked food, coffee, alcoholic beverages and tobacco smoke. beta-Carbolines have previously been detected in higher levels in the pigmented substantia nigra than in the cortex of humans. The distribution of H-3-labelled harman and norharman in the brain of pigmented and albino mice and in frogs (a species having neuromelanin) was studied by tape-section and light-microscopic autoradiography. Furthermore, the binding of these beta-carbolines to dopamine-melanin and melanin granules from Sepia officinalis was examined. The results revealed a high affinity binding to melanin and a long-term retention (up to 30 days) in pigmented tissues, including neuromelanin-containing neurons of frogs after a single injection. The role of long-term exposure to food-related beta-carbolines and a retention of these compounds in pigment-containing neurons in the induction of idiopathic Parkinson's disease should be further considered.},
  author       = {Ostergren, A and Annas, A and Skog, Kerstin and Lindquist, N G and Brittebo, E B},
  issn         = {0300-9564},
  keyword      = {b-Carbolines,parkinsonism,neuromelanin,harman,norharman,Parkinson’s disease,dopamine–melanin,Sepia officinalis},
  language     = {eng},
  number       = {2},
  pages        = {141--157},
  publisher    = {Springer},
  series       = {Journal of Neural Transmission},
  title        = {Long-term retention of neurotoxic beta-carbolines in brain neuromelanin},
  url          = {http://dx.doi.org/10.1007/s00702-003-0080-0},
  volume       = {111},
  year         = {2004},
}