Long-term retention of neurotoxic beta-carbolines in brain neuromelanin
(2004) In Journal of Neural Transmission 111(2). p.141-157- Abstract
- beta-Carbolines show structural resemblance to the neurotoxic N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and are metabolized to mitochondrial toxicants. Humans are continuously exposed to low levels of beta-carbolines through cooked food, coffee, alcoholic beverages and tobacco smoke. beta-Carbolines have previously been detected in higher levels in the pigmented substantia nigra than in the cortex of humans. The distribution of H-3-labelled harman and norharman in the brain of pigmented and albino mice and in frogs (a species having neuromelanin) was studied by tape-section and light-microscopic autoradiography. Furthermore, the binding of these beta-carbolines to dopamine-melanin and melanin granules from Sepia officinalis was... (More)
- beta-Carbolines show structural resemblance to the neurotoxic N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and are metabolized to mitochondrial toxicants. Humans are continuously exposed to low levels of beta-carbolines through cooked food, coffee, alcoholic beverages and tobacco smoke. beta-Carbolines have previously been detected in higher levels in the pigmented substantia nigra than in the cortex of humans. The distribution of H-3-labelled harman and norharman in the brain of pigmented and albino mice and in frogs (a species having neuromelanin) was studied by tape-section and light-microscopic autoradiography. Furthermore, the binding of these beta-carbolines to dopamine-melanin and melanin granules from Sepia officinalis was examined. The results revealed a high affinity binding to melanin and a long-term retention (up to 30 days) in pigmented tissues, including neuromelanin-containing neurons of frogs after a single injection. The role of long-term exposure to food-related beta-carbolines and a retention of these compounds in pigment-containing neurons in the induction of idiopathic Parkinson's disease should be further considered. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/138648
- author
- Ostergren, A ; Annas, A ; Skog, Kerstin LU ; Lindquist, N G and Brittebo, E B
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- b-Carbolines, parkinsonism, neuromelanin, harman, norharman, Parkinson’s disease, dopamine–melanin, Sepia officinalis
- in
- Journal of Neural Transmission
- volume
- 111
- issue
- 2
- pages
- 141 - 157
- publisher
- Springer
- external identifiers
-
- pmid:14767717
- wos:000188839000003
- scopus:1442265714
- ISSN
- 0300-9564
- DOI
- 10.1007/s00702-003-0080-0
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Applied Nutrition and Food Chemistry (011001300)
- id
- 9223e463-6a09-4b5a-b992-27b3a8910d24 (old id 138648)
- date added to LUP
- 2016-04-01 17:11:03
- date last changed
- 2023-09-05 08:41:29
@article{9223e463-6a09-4b5a-b992-27b3a8910d24,
abstract = {{beta-Carbolines show structural resemblance to the neurotoxic N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and are metabolized to mitochondrial toxicants. Humans are continuously exposed to low levels of beta-carbolines through cooked food, coffee, alcoholic beverages and tobacco smoke. beta-Carbolines have previously been detected in higher levels in the pigmented substantia nigra than in the cortex of humans. The distribution of H-3-labelled harman and norharman in the brain of pigmented and albino mice and in frogs (a species having neuromelanin) was studied by tape-section and light-microscopic autoradiography. Furthermore, the binding of these beta-carbolines to dopamine-melanin and melanin granules from Sepia officinalis was examined. The results revealed a high affinity binding to melanin and a long-term retention (up to 30 days) in pigmented tissues, including neuromelanin-containing neurons of frogs after a single injection. The role of long-term exposure to food-related beta-carbolines and a retention of these compounds in pigment-containing neurons in the induction of idiopathic Parkinson's disease should be further considered.}},
author = {{Ostergren, A and Annas, A and Skog, Kerstin and Lindquist, N G and Brittebo, E B}},
issn = {{0300-9564}},
keywords = {{b-Carbolines; parkinsonism; neuromelanin; harman; norharman; Parkinson’s disease; dopamine–melanin; Sepia officinalis}},
language = {{eng}},
number = {{2}},
pages = {{141--157}},
publisher = {{Springer}},
series = {{Journal of Neural Transmission}},
title = {{Long-term retention of neurotoxic beta-carbolines in brain neuromelanin}},
url = {{http://dx.doi.org/10.1007/s00702-003-0080-0}},
doi = {{10.1007/s00702-003-0080-0}},
volume = {{111}},
year = {{2004}},
}