Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Evaluation of the effects of exercise on insulin sensitivity in Arabian and Swedish women with type 2 diabetes.

Glans, Forouzan LU ; Eriksson, Karl-Fredrik LU ; Tornberg, Åsa LU orcid ; Thorsson, Ola LU ; Wollmer, Per LU and Groop, Leif LU (2009) In Diabetes Research and Clinical Practice 85. p.69-74
Abstract
AIMS: The purpose of this study was to evaluate the effects of exercise on cardio-respiratory fitness and insulin sensitivity in sedentary, overweight Arabian and Swedish women with type 2 diabetes. METHODS: Eighteen Arabian and 14 Swedish women participated in a supervised 6-month resistance training and aerobic program of moderate intensity. Insulin sensitivity and VO(2max) were measured at entry to the study and after 3 and 6 months training. RESULTS: After 6 months exercise, insulin sensitivity (M-value) increased (2.7+/-1.4mgkg(-1)min(-1) vs. 3.4+/-2mgkg(-1)min(-1), p<0.05) in all patients and accounted for by an increase in non-oxidative glucose metabolism (0.3+/-1.1mgkg(-1)min(-1) vs. 1.5+/-1.5mgkg(-1)min(-1), p<0.005) with no... (More)
AIMS: The purpose of this study was to evaluate the effects of exercise on cardio-respiratory fitness and insulin sensitivity in sedentary, overweight Arabian and Swedish women with type 2 diabetes. METHODS: Eighteen Arabian and 14 Swedish women participated in a supervised 6-month resistance training and aerobic program of moderate intensity. Insulin sensitivity and VO(2max) were measured at entry to the study and after 3 and 6 months training. RESULTS: After 6 months exercise, insulin sensitivity (M-value) increased (2.7+/-1.4mgkg(-1)min(-1) vs. 3.4+/-2mgkg(-1)min(-1), p<0.05) in all patients and accounted for by an increase in non-oxidative glucose metabolism (0.3+/-1.1mgkg(-1)min(-1) vs. 1.5+/-1.5mgkg(-1)min(-1), p<0.005) with no significant difference between the ethnic groups. Notably, significant improvement in HbA1c was only seen in the Swedish patients who achieved greater exercise intensity (73.3+/-4.8% vs. 63.3+/-5.2% of maximum heart rate, p<0.005). No changes were observed regarding VO(2max) or lipid profile in either group. CONCLUSIONS: Although a 6-month exercise intervention of moderate intensity in Arabian and Swedish patients with type 2 diabetes can improve insulin sensitivity it is hampered by the metabolic inflexibility of switching between oxidation of glucose or fat. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Research and Clinical Practice
volume
85
pages
69 - 74
publisher
Elsevier
external identifiers
  • wos:000267913300012
  • pmid:19447515
  • scopus:67349265111
  • pmid:19447515
ISSN
1872-8227
DOI
10.1016/j.diabres.2009.04.018
project
Fysik aktivitet, träning och kost vid typ 2 diabetes
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Unit for Clinical Vascular Disease Research (013242410), Clinical Physiology and Nuclear Medicine Unit (013242320), Division of Physiotherapy (Closed 2012) (013042000), Diabetes and Endocrinology (013241530)
id
e7587a4f-1d82-428b-ba0d-6d545b673028 (old id 1412219)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19447515?dopt=Abstract
date added to LUP
2016-04-04 07:18:14
date last changed
2024-01-12 01:01:08
@article{e7587a4f-1d82-428b-ba0d-6d545b673028,
  abstract     = {{AIMS: The purpose of this study was to evaluate the effects of exercise on cardio-respiratory fitness and insulin sensitivity in sedentary, overweight Arabian and Swedish women with type 2 diabetes. METHODS: Eighteen Arabian and 14 Swedish women participated in a supervised 6-month resistance training and aerobic program of moderate intensity. Insulin sensitivity and VO(2max) were measured at entry to the study and after 3 and 6 months training. RESULTS: After 6 months exercise, insulin sensitivity (M-value) increased (2.7+/-1.4mgkg(-1)min(-1) vs. 3.4+/-2mgkg(-1)min(-1), p&lt;0.05) in all patients and accounted for by an increase in non-oxidative glucose metabolism (0.3+/-1.1mgkg(-1)min(-1) vs. 1.5+/-1.5mgkg(-1)min(-1), p&lt;0.005) with no significant difference between the ethnic groups. Notably, significant improvement in HbA1c was only seen in the Swedish patients who achieved greater exercise intensity (73.3+/-4.8% vs. 63.3+/-5.2% of maximum heart rate, p&lt;0.005). No changes were observed regarding VO(2max) or lipid profile in either group. CONCLUSIONS: Although a 6-month exercise intervention of moderate intensity in Arabian and Swedish patients with type 2 diabetes can improve insulin sensitivity it is hampered by the metabolic inflexibility of switching between oxidation of glucose or fat.}},
  author       = {{Glans, Forouzan and Eriksson, Karl-Fredrik and Tornberg, Åsa and Thorsson, Ola and Wollmer, Per and Groop, Leif}},
  issn         = {{1872-8227}},
  language     = {{eng}},
  pages        = {{69--74}},
  publisher    = {{Elsevier}},
  series       = {{Diabetes Research and Clinical Practice}},
  title        = {{Evaluation of the effects of exercise on insulin sensitivity in Arabian and Swedish women with type 2 diabetes.}},
  url          = {{http://dx.doi.org/10.1016/j.diabres.2009.04.018}},
  doi          = {{10.1016/j.diabres.2009.04.018}},
  volume       = {{85}},
  year         = {{2009}},
}