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Evaluation of the effects of exercise on insulin sensitivity in Arabian and Swedish women with type 2 diabetes.

Glans, Forouzan LU ; Eriksson, Karl-Fredrik LU ; Tornberg, Åsa LU orcid ; Thorsson, Ola LU ; Wollmer, Per LU and Groop, Leif LU (2009) In Diabetes Research and Clinical Practice 85. p.69-74
Abstract
AIMS: The purpose of this study was to evaluate the effects of exercise on cardio-respiratory fitness and insulin sensitivity in sedentary, overweight Arabian and Swedish women with type 2 diabetes. METHODS: Eighteen Arabian and 14 Swedish women participated in a supervised 6-month resistance training and aerobic program of moderate intensity. Insulin sensitivity and VO(2max) were measured at entry to the study and after 3 and 6 months training. RESULTS: After 6 months exercise, insulin sensitivity (M-value) increased (2.7+/-1.4mgkg(-1)min(-1) vs. 3.4+/-2mgkg(-1)min(-1), p<0.05) in all patients and accounted for by an increase in non-oxidative glucose metabolism (0.3+/-1.1mgkg(-1)min(-1) vs. 1.5+/-1.5mgkg(-1)min(-1), p<0.005) with no... (More)
AIMS: The purpose of this study was to evaluate the effects of exercise on cardio-respiratory fitness and insulin sensitivity in sedentary, overweight Arabian and Swedish women with type 2 diabetes. METHODS: Eighteen Arabian and 14 Swedish women participated in a supervised 6-month resistance training and aerobic program of moderate intensity. Insulin sensitivity and VO(2max) were measured at entry to the study and after 3 and 6 months training. RESULTS: After 6 months exercise, insulin sensitivity (M-value) increased (2.7+/-1.4mgkg(-1)min(-1) vs. 3.4+/-2mgkg(-1)min(-1), p<0.05) in all patients and accounted for by an increase in non-oxidative glucose metabolism (0.3+/-1.1mgkg(-1)min(-1) vs. 1.5+/-1.5mgkg(-1)min(-1), p<0.005) with no significant difference between the ethnic groups. Notably, significant improvement in HbA1c was only seen in the Swedish patients who achieved greater exercise intensity (73.3+/-4.8% vs. 63.3+/-5.2% of maximum heart rate, p<0.005). No changes were observed regarding VO(2max) or lipid profile in either group. CONCLUSIONS: Although a 6-month exercise intervention of moderate intensity in Arabian and Swedish patients with type 2 diabetes can improve insulin sensitivity it is hampered by the metabolic inflexibility of switching between oxidation of glucose or fat. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Research and Clinical Practice
volume
85
pages
69 - 74
publisher
Elsevier
external identifiers
  • wos:000267913300012
  • pmid:19447515
  • scopus:67349265111
  • pmid:19447515
ISSN
1872-8227
DOI
10.1016/j.diabres.2009.04.018
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Unit for Clinical Vascular Disease Research (013242410), Clinical Physiology and Nuclear Medicine Unit (013242320), Division of Physiotherapy (Closed 2012) (013042000), Diabetes and Endocrinology (013241530)
id
e7587a4f-1d82-428b-ba0d-6d545b673028 (old id 1412219)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19447515?dopt=Abstract
date added to LUP
2016-04-04 07:18:14
date last changed
2021-03-24 03:36:47
@article{e7587a4f-1d82-428b-ba0d-6d545b673028,
  abstract     = {AIMS: The purpose of this study was to evaluate the effects of exercise on cardio-respiratory fitness and insulin sensitivity in sedentary, overweight Arabian and Swedish women with type 2 diabetes. METHODS: Eighteen Arabian and 14 Swedish women participated in a supervised 6-month resistance training and aerobic program of moderate intensity. Insulin sensitivity and VO(2max) were measured at entry to the study and after 3 and 6 months training. RESULTS: After 6 months exercise, insulin sensitivity (M-value) increased (2.7+/-1.4mgkg(-1)min(-1) vs. 3.4+/-2mgkg(-1)min(-1), p&lt;0.05) in all patients and accounted for by an increase in non-oxidative glucose metabolism (0.3+/-1.1mgkg(-1)min(-1) vs. 1.5+/-1.5mgkg(-1)min(-1), p&lt;0.005) with no significant difference between the ethnic groups. Notably, significant improvement in HbA1c was only seen in the Swedish patients who achieved greater exercise intensity (73.3+/-4.8% vs. 63.3+/-5.2% of maximum heart rate, p&lt;0.005). No changes were observed regarding VO(2max) or lipid profile in either group. CONCLUSIONS: Although a 6-month exercise intervention of moderate intensity in Arabian and Swedish patients with type 2 diabetes can improve insulin sensitivity it is hampered by the metabolic inflexibility of switching between oxidation of glucose or fat.},
  author       = {Glans, Forouzan and Eriksson, Karl-Fredrik and Tornberg, Åsa and Thorsson, Ola and Wollmer, Per and Groop, Leif},
  issn         = {1872-8227},
  language     = {eng},
  pages        = {69--74},
  publisher    = {Elsevier},
  series       = {Diabetes Research and Clinical Practice},
  title        = {Evaluation of the effects of exercise on insulin sensitivity in Arabian and Swedish women with type 2 diabetes.},
  url          = {http://dx.doi.org/10.1016/j.diabres.2009.04.018},
  doi          = {10.1016/j.diabres.2009.04.018},
  volume       = {85},
  year         = {2009},
}