Alzheimer's disease (AD) and executive dysfunction. A case-control study on the significance of frontal white matter changes detected by diffusion tensor imaging (DTI).
(2010) In Archives of Gerontology and Geriatrics 50. p.260-266- Abstract
- White matter (WM) changes are frequently seen on structural imaging in AD but the clinical relevance of these changes is uncertain. Frontal WM pathology is often observed upon neuropathological examination in AD. Since frontal cortical/sub-cortical pathology is known to relate to executive dysfunction, the aim was to elucidate if frontal WM changes in AD correlated with executive dysfunction. In all, 15 AD patients and 15 age-matched control cases were investigated in the study, which covered conventional magnetic resonance imaging (MRI), DTI, neuropsychiatric and neuropsychological examinations. Reduced performance on neuropsychological testing of executive function correlated significantly with an increasing degree of frontal WM changes... (More)
- White matter (WM) changes are frequently seen on structural imaging in AD but the clinical relevance of these changes is uncertain. Frontal WM pathology is often observed upon neuropathological examination in AD. Since frontal cortical/sub-cortical pathology is known to relate to executive dysfunction, the aim was to elucidate if frontal WM changes in AD correlated with executive dysfunction. In all, 15 AD patients and 15 age-matched control cases were investigated in the study, which covered conventional magnetic resonance imaging (MRI), DTI, neuropsychiatric and neuropsychological examinations. Reduced performance on neuropsychological testing of executive function correlated significantly with an increasing degree of frontal WM changes detected by DTI in the AD group, while no such correlation was observed for the controls. Conventional semi-quantitative MRI assessment did not correlate with results on neuropsychological testing of executive function in any of the groups. The structural correlate to certain dimensions of executive dysfunction in AD patients could be related to changes in the deep frontal WM. DTI appears to be more sensitive in the detection of clinically significant WM alterations than conventional semi-quantitative MRI. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1412630
- author
- Sjöbeck, Martin LU ; Elfgren, Christina LU ; Larsson, Elna-Marie LU ; Brockstedt, Sara LU ; Lätt, Jimmy LU ; Englund, Elisabet LU and Passant, Ulla LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Archives of Gerontology and Geriatrics
- volume
- 50
- pages
- 260 - 266
- publisher
- Elsevier
- external identifiers
-
- wos:000276454900004
- pmid:19419776
- scopus:77649178915
- ISSN
- 1872-6976
- DOI
- 10.1016/j.archger.2009.03.014
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Psychology (012010000), Pathology, (Lund) (013030000), Radiation Physics, Lund (013034000), Diagnostic Radiology, (Lund) (013038000), Department of Psychogeriatrics (013304000)
- id
- 96fc7a63-47d5-46f8-acdc-f5dec94cef29 (old id 1412630)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19419776?dopt=Abstract
- date added to LUP
- 2016-04-04 09:08:55
- date last changed
- 2022-01-29 08:28:15
@article{96fc7a63-47d5-46f8-acdc-f5dec94cef29, abstract = {{White matter (WM) changes are frequently seen on structural imaging in AD but the clinical relevance of these changes is uncertain. Frontal WM pathology is often observed upon neuropathological examination in AD. Since frontal cortical/sub-cortical pathology is known to relate to executive dysfunction, the aim was to elucidate if frontal WM changes in AD correlated with executive dysfunction. In all, 15 AD patients and 15 age-matched control cases were investigated in the study, which covered conventional magnetic resonance imaging (MRI), DTI, neuropsychiatric and neuropsychological examinations. Reduced performance on neuropsychological testing of executive function correlated significantly with an increasing degree of frontal WM changes detected by DTI in the AD group, while no such correlation was observed for the controls. Conventional semi-quantitative MRI assessment did not correlate with results on neuropsychological testing of executive function in any of the groups. The structural correlate to certain dimensions of executive dysfunction in AD patients could be related to changes in the deep frontal WM. DTI appears to be more sensitive in the detection of clinically significant WM alterations than conventional semi-quantitative MRI.}}, author = {{Sjöbeck, Martin and Elfgren, Christina and Larsson, Elna-Marie and Brockstedt, Sara and Lätt, Jimmy and Englund, Elisabet and Passant, Ulla}}, issn = {{1872-6976}}, language = {{eng}}, pages = {{260--266}}, publisher = {{Elsevier}}, series = {{Archives of Gerontology and Geriatrics}}, title = {{Alzheimer's disease (AD) and executive dysfunction. A case-control study on the significance of frontal white matter changes detected by diffusion tensor imaging (DTI).}}, url = {{http://dx.doi.org/10.1016/j.archger.2009.03.014}}, doi = {{10.1016/j.archger.2009.03.014}}, volume = {{50}}, year = {{2010}}, }