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Platinum, palladium, rhodium, molybdenum and strontium in blood of urban women in nine countries

Rentschler, Gerda LU ; Rodushkin, Ilia; Cerna, Milena; Chen, Chunying; Harari, Florencia; Harari, Raúl; Horvat, Milena; Hruba, Frantiska; Kasparova, Lucie and Koppova, Kvetoslava, et al. (2017) In International Journal of Hygiene and Environmental Health
Abstract

Background: There is little reliable information on human exposure to the metals platinum (Pt), palladium (Pd) and rhodium (Rh), despite their use in enormous quantities in catalytic converters for automobile exhaust systems. Objectives: To evaluate blood concentrations of Pt (B-Pt), Pd (B-Pd) and Rh (B-Rh) in women from six European and three non-European countries, and to identify potentially influential factors. In addition, molybdenum (Mo) and strontium (Sr) were analysed. Methods: Blood from 248 women aged 47-61 was analysed by high resolution inductively coupled plasma mass spectrometry under strict quality control. Results: The medians were: B-Pt 0.8 (range <0.6-5.2), B-Pd <5 (<5-9.3), B-Rh <0.4 (<0.4-3.6). ng/L... (More)

Background: There is little reliable information on human exposure to the metals platinum (Pt), palladium (Pd) and rhodium (Rh), despite their use in enormous quantities in catalytic converters for automobile exhaust systems. Objectives: To evaluate blood concentrations of Pt (B-Pt), Pd (B-Pd) and Rh (B-Rh) in women from six European and three non-European countries, and to identify potentially influential factors. In addition, molybdenum (Mo) and strontium (Sr) were analysed. Methods: Blood from 248 women aged 47-61 was analysed by high resolution inductively coupled plasma mass spectrometry under strict quality control. Results: The medians were: B-Pt 0.8 (range <0.6-5.2), B-Pd <5 (<5-9.3), B-Rh <0.4 (<0.4-3.6). ng/L and B-Mo 2.0 (0.2-16) and B-Sr 16.6 (3.5-49) μg/L. Two women with highly elevated B-Pt (242 and 60. ng/L), previously cancer treated with cis-platinum, were not included in the data analysis. All elements varied geographically (2-3 times) (B-Pd P = 0.05; all other elements P. <. 0.001); variations within each area were generally 5-10 times. Traffic was not associated with increased concentrations. Conclusions: General population blood concentrations of Pt, Pd and Rh are within or below the single digit ng/L range, much lower than in most previous reports. This is probably due to improved analytical performance, allowing for more reliable information at ultra-trace levels. In general, Mo and Sr agreed with previously reported concentrations. All elements showed geographical and inter-individual variations, but no convincing relationships with self-reported traffic intensity were found. Pt from the antineoplastic drug cis-platinum is retained in the body for years.

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keywords
Biomarkers, Biomonitoring, Catalytic converters, Cis-platinum, High-resolution ICP-MS, Human, Metals, Traffic, Women
in
International Journal of Hygiene and Environmental Health
publisher
Elsevier
external identifiers
  • scopus:85034617573
ISSN
1438-4639
DOI
10.1016/j.ijheh.2017.10.017
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English
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yes
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142193d4-d326-4c65-9afb-238f700c9fff
date added to LUP
2017-12-28 10:34:44
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2018-03-30 03:00:15
@article{142193d4-d326-4c65-9afb-238f700c9fff,
  abstract     = {<p>Background: There is little reliable information on human exposure to the metals platinum (Pt), palladium (Pd) and rhodium (Rh), despite their use in enormous quantities in catalytic converters for automobile exhaust systems. Objectives: To evaluate blood concentrations of Pt (B-Pt), Pd (B-Pd) and Rh (B-Rh) in women from six European and three non-European countries, and to identify potentially influential factors. In addition, molybdenum (Mo) and strontium (Sr) were analysed. Methods: Blood from 248 women aged 47-61 was analysed by high resolution inductively coupled plasma mass spectrometry under strict quality control. Results: The medians were: B-Pt 0.8 (range &lt;0.6-5.2), B-Pd &lt;5 (&lt;5-9.3), B-Rh &lt;0.4 (&lt;0.4-3.6). ng/L and B-Mo 2.0 (0.2-16) and B-Sr 16.6 (3.5-49) μg/L. Two women with highly elevated B-Pt (242 and 60. ng/L), previously cancer treated with cis-platinum, were not included in the data analysis. All elements varied geographically (2-3 times) (B-Pd P = 0.05; all other elements P. &lt;. 0.001); variations within each area were generally 5-10 times. Traffic was not associated with increased concentrations. Conclusions: General population blood concentrations of Pt, Pd and Rh are within or below the single digit ng/L range, much lower than in most previous reports. This is probably due to improved analytical performance, allowing for more reliable information at ultra-trace levels. In general, Mo and Sr agreed with previously reported concentrations. All elements showed geographical and inter-individual variations, but no convincing relationships with self-reported traffic intensity were found. Pt from the antineoplastic drug cis-platinum is retained in the body for years.</p>},
  author       = {Rentschler, Gerda and Rodushkin, Ilia and Cerna, Milena and Chen, Chunying and Harari, Florencia and Harari, Raúl and Horvat, Milena and Hruba, Frantiska and Kasparova, Lucie and Koppova, Kvetoslava and Krskova, Andrea and Krsnik, Mladen and Laamech, Jawhar and Li, Yu Feng and Löfmark, Lina and Lundh, Thomas and Lundström, Nils Göran and Lyoussi, Badiaa and Mazej, Darja and Osredkar, Josko and Pawlas, Krystyna and Pawlas, Natalia and Prokopowicz, Adam and Skerfving, Staffan and Snoj Tratnik, Janja and Spevackova, Vera and Spiric, Zdravko and Sundkvist, Anneli and Strömberg, Ulf and Vadla, Drazenka and Wranova, Katerina and Zizi, Soumia and Bergdahl, Ingvar A.},
  issn         = {1438-4639},
  keyword      = {Biomarkers,Biomonitoring,Catalytic converters,Cis-platinum,High-resolution ICP-MS,Human,Metals,Traffic,Women},
  language     = {eng},
  month        = {11},
  publisher    = {Elsevier},
  series       = {International Journal of Hygiene and Environmental Health},
  title        = {Platinum, palladium, rhodium, molybdenum and strontium in blood of urban women in nine countries},
  url          = {http://dx.doi.org/10.1016/j.ijheh.2017.10.017},
  year         = {2017},
}