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Prospective analysis of risk factors and distribution of venous thromboembolism in the population-based Malmö Thrombophilia Study (MATS).

Isma, Nazim LU ; Svensson, Peter LU ; Gottsäter, Anders LU and Lindblad, Bengt LU (2009) In Thrombosis Research 124. p.663-666
Abstract
BACKGROUND: Despite venous thromboembolism (VTE) being a major cause of morbidity and mortality, there is still limited information on its prevalence and incidence in the general population. OBJECTIVE: To evaluate risk factors, distribution and epidemiology of VTE in the Malmö area with 280 000 inhabitants. METHODS: Patients diagnosed with VTE at Malmö University Hospital in 1998-2006 were invited to a prospective population-based study. Blood sampling and a questionnaire study could be performed in 70% of patients. Remaining 30% were excluded due to language problems, dementia, other severe disease, or unwillingness to participate. RESULTS: During 1998-2006 1140 VTE patients (559 men [49%, age 62+/-16 years] and 581 women [51%, age... (More)
BACKGROUND: Despite venous thromboembolism (VTE) being a major cause of morbidity and mortality, there is still limited information on its prevalence and incidence in the general population. OBJECTIVE: To evaluate risk factors, distribution and epidemiology of VTE in the Malmö area with 280 000 inhabitants. METHODS: Patients diagnosed with VTE at Malmö University Hospital in 1998-2006 were invited to a prospective population-based study. Blood sampling and a questionnaire study could be performed in 70% of patients. Remaining 30% were excluded due to language problems, dementia, other severe disease, or unwillingness to participate. RESULTS: During 1998-2006 1140 VTE patients (559 men [49%, age 62+/-16 years] and 581 women [51%, age 61+/-20 years]) were included. Deep venous thrombosis (DVT) occurred in 882 (77%), pulmonary embolism (PE) in 330 (29%), and both DVT and PE in 72 (6%). The most common acquired risk factors among VTE patients were hormone therapy (24% of female DVT patients and 19% of female PE patients), immobilisation (17% of DVT patients and 18% of PE patients), previous surgery (13% of DVT patients and 19% of PE patients), and concomitant malignant disease (12% of DVT patients and 11% of PE patients). A positive family history for VTE was obtained from 25% of DVT patients and 22% of PE patients. Yearly incidences of VTE, DVT and PE in Malmö were 66, 51, and 19/100.000, respectively. CONCLUSION: Hormone therapy, immobilisation, previous surgery and concomitant malignancy were the most common acquired risk factors among VTE patients in this population-based study. The VTE-incidence was lower than in earlier epidemiological studies. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Thrombosis Research
volume
124
pages
663 - 666
publisher
Elsevier Ltd
external identifiers
  • wos:000272857500006
  • pmid:19497611
  • scopus:70449532380
ISSN
1879-2472
DOI
10.1016/j.thromres.2009.04.022
language
English
LU publication?
yes
id
3fbad433-088f-4001-b101-81399c29f820 (old id 1434479)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19497611?dopt=Abstract
date added to LUP
2009-07-03 08:54:04
date last changed
2017-12-10 03:46:51
@article{3fbad433-088f-4001-b101-81399c29f820,
  abstract     = {BACKGROUND: Despite venous thromboembolism (VTE) being a major cause of morbidity and mortality, there is still limited information on its prevalence and incidence in the general population. OBJECTIVE: To evaluate risk factors, distribution and epidemiology of VTE in the Malmö area with 280 000 inhabitants. METHODS: Patients diagnosed with VTE at Malmö University Hospital in 1998-2006 were invited to a prospective population-based study. Blood sampling and a questionnaire study could be performed in 70% of patients. Remaining 30% were excluded due to language problems, dementia, other severe disease, or unwillingness to participate. RESULTS: During 1998-2006 1140 VTE patients (559 men [49%, age 62+/-16 years] and 581 women [51%, age 61+/-20 years]) were included. Deep venous thrombosis (DVT) occurred in 882 (77%), pulmonary embolism (PE) in 330 (29%), and both DVT and PE in 72 (6%). The most common acquired risk factors among VTE patients were hormone therapy (24% of female DVT patients and 19% of female PE patients), immobilisation (17% of DVT patients and 18% of PE patients), previous surgery (13% of DVT patients and 19% of PE patients), and concomitant malignant disease (12% of DVT patients and 11% of PE patients). A positive family history for VTE was obtained from 25% of DVT patients and 22% of PE patients. Yearly incidences of VTE, DVT and PE in Malmö were 66, 51, and 19/100.000, respectively. CONCLUSION: Hormone therapy, immobilisation, previous surgery and concomitant malignancy were the most common acquired risk factors among VTE patients in this population-based study. The VTE-incidence was lower than in earlier epidemiological studies.},
  author       = {Isma, Nazim and Svensson, Peter and Gottsäter, Anders and Lindblad, Bengt},
  issn         = {1879-2472},
  language     = {eng},
  pages        = {663--666},
  publisher    = {Elsevier Ltd},
  series       = {Thrombosis Research},
  title        = {Prospective analysis of risk factors and distribution of venous thromboembolism in the population-based Malmö Thrombophilia Study (MATS).},
  url          = {http://dx.doi.org/10.1016/j.thromres.2009.04.022},
  volume       = {124},
  year         = {2009},
}