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Serum calcium and tumour aggressiveness in breast cancer: a prospective study of 7847 women.

Almquist, Martin LU ; Anagnostaki, Lola; Bondeson, Lennart LU ; Bondeson, Anne-Greth LU ; Borgquist, Signe LU ; Landberg, Göran LU ; Malina, Janne; Malm, Johan LU and Manjer, Jonas LU (2009) In European Journal of Cancer Prevention 18. p.354-360
Abstract
Experimental, epidemiological and clinical studies suggest that calcium and/or its regulating hormones affect breast cancer risk. There has been no prospective cohort study investigating serum calcium levels and breast cancer aggressiveness, as determined by tumour histology and stage. Dichotomized prediagnostic serum calcium levels were investigated in relation to breast cancer aggressiveness as determined by grade (mitotic frequency, tubule formation, nuclear atypia) and stage (tumour size and axillary lymph node status). Cox's proportional hazards analysis and heterogeneity analysis were used to investigate the associations between low/high calcium and grade/stage in a prospective cohort study of 7847 women, out of whom 462 women were... (More)
Experimental, epidemiological and clinical studies suggest that calcium and/or its regulating hormones affect breast cancer risk. There has been no prospective cohort study investigating serum calcium levels and breast cancer aggressiveness, as determined by tumour histology and stage. Dichotomized prediagnostic serum calcium levels were investigated in relation to breast cancer aggressiveness as determined by grade (mitotic frequency, tubule formation, nuclear atypia) and stage (tumour size and axillary lymph node status). Cox's proportional hazards analysis and heterogeneity analysis were used to investigate the associations between low/high calcium and grade/stage in a prospective cohort study of 7847 women, out of whom 462 women were diagnosed with incident breast cancer during a mean follow-up of 17.2 years. All analyses were stratified for body mass index and menopausal status. Prediagnostic serum calcium levels in premenopausal women were positively associated with increased tumour aggressiveness as determined by a higher risk of nodal metastasis; relative risk (RR) for calcium above median as compared with calcium below median was 1.88 with a 95% confidence interval (CI) of 1.04-3.38. In overweight women, prediagnostic serum calcium levels were also associated with tumour aggressiveness, as determined by both a higher risk of nodal metastasis [RR (95% CI) 1.69 (0.95-3.02)] and severe nuclear atypia [RR (95% CI) 2.06 (1.10-3.86)]. Results also indicate that, in overweight women, calcium is positively associated with worse grade as determined by tubule formation and mitotic frequency. In conclusion, prediagnostic serum calcium levels are positively associated with increased tumour aggressiveness in premenopausal and/or overweight women. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Cancer Prevention
volume
18
pages
354 - 360
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000268869200003
  • pmid:19593149
  • scopus:69749110306
ISSN
1473-5709
DOI
10.1097/CEJ.0b013e32832c386f
language
English
LU publication?
yes
id
1bad0aff-755a-49a0-80ce-4321d02eefbd (old id 1453160)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19593149?dopt=Abstract
date added to LUP
2009-08-04 11:47:54
date last changed
2017-09-10 04:44:41
@article{1bad0aff-755a-49a0-80ce-4321d02eefbd,
  abstract     = {Experimental, epidemiological and clinical studies suggest that calcium and/or its regulating hormones affect breast cancer risk. There has been no prospective cohort study investigating serum calcium levels and breast cancer aggressiveness, as determined by tumour histology and stage. Dichotomized prediagnostic serum calcium levels were investigated in relation to breast cancer aggressiveness as determined by grade (mitotic frequency, tubule formation, nuclear atypia) and stage (tumour size and axillary lymph node status). Cox's proportional hazards analysis and heterogeneity analysis were used to investigate the associations between low/high calcium and grade/stage in a prospective cohort study of 7847 women, out of whom 462 women were diagnosed with incident breast cancer during a mean follow-up of 17.2 years. All analyses were stratified for body mass index and menopausal status. Prediagnostic serum calcium levels in premenopausal women were positively associated with increased tumour aggressiveness as determined by a higher risk of nodal metastasis; relative risk (RR) for calcium above median as compared with calcium below median was 1.88 with a 95% confidence interval (CI) of 1.04-3.38. In overweight women, prediagnostic serum calcium levels were also associated with tumour aggressiveness, as determined by both a higher risk of nodal metastasis [RR (95% CI) 1.69 (0.95-3.02)] and severe nuclear atypia [RR (95% CI) 2.06 (1.10-3.86)]. Results also indicate that, in overweight women, calcium is positively associated with worse grade as determined by tubule formation and mitotic frequency. In conclusion, prediagnostic serum calcium levels are positively associated with increased tumour aggressiveness in premenopausal and/or overweight women.},
  author       = {Almquist, Martin and Anagnostaki, Lola and Bondeson, Lennart and Bondeson, Anne-Greth and Borgquist, Signe and Landberg, Göran and Malina, Janne and Malm, Johan and Manjer, Jonas},
  issn         = {1473-5709},
  language     = {eng},
  pages        = {354--360},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {European Journal of Cancer Prevention},
  title        = {Serum calcium and tumour aggressiveness in breast cancer: a prospective study of 7847 women.},
  url          = {http://dx.doi.org/10.1097/CEJ.0b013e32832c386f},
  volume       = {18},
  year         = {2009},
}