Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity.
Sonestedt, Emily LU
; Roos, Charlotta
LU
; Gullberg, Bo
LU
; Ericson, Ulrika
LU
; Wirfält, Elisabet
LU
and Orho-Melander, Marju
LU
(2009)
In The American journal of clinical nutrition
90.
p.1418-1425
- Abstract
- BACKGROUND: The fat mass and obesity-associated gene (FTO) has been shown to be associated with obesity and to influence appetite regulation. OBJECTIVE: The aim was to examine whether dietary factors (macronutrient and fiber intakes) and leisure-time physical activity modify the association between genetic variation in FTO and body mass index (BMI; in kg/m(2)). DESIGN: A cross-sectional study examined 4839 subjects in the population-based Malmö Diet and Cancer study with dietary data (from a modified diet history method) and information on the genetic variant FTO (rs9939609). Direct anthropometric measures were made, and leisure-time physical activity was determined from the duration participants spent on 18 different physical activities.... (More)
- BACKGROUND: The fat mass and obesity-associated gene (FTO) has been shown to be associated with obesity and to influence appetite regulation. OBJECTIVE: The aim was to examine whether dietary factors (macronutrient and fiber intakes) and leisure-time physical activity modify the association between genetic variation in FTO and body mass index (BMI; in kg/m(2)). DESIGN: A cross-sectional study examined 4839 subjects in the population-based Malmö Diet and Cancer study with dietary data (from a modified diet history method) and information on the genetic variant FTO (rs9939609). Direct anthropometric measures were made, and leisure-time physical activity was determined from the duration participants spent on 18 different physical activities. RESULTS: Significant interactions between energy-adjusted fat intake and FTO genotype (P = 0.04) and between carbohydrate intake and FTO genotype (P = 0.001) on BMI were observed. The observed increase in BMI across FTO genotypes was restricted to those who reported a high-fat diet, with a mean BMI of 25.3 (95% CI: 24.9, 25.6) among TT carriers and of 26.3 (95% CI: 25.8, 26.8) among AA carriers (P = 0.0001). The FTO variant was not associated with a higher BMI among subjects with lower fat intakes (BMI = 25.7 and 25.9 in TT carriers and AA carriers, respectively; P = 0.42). Among individuals with a low-carbohydrate intake, we observed a mean BMI of 25.4 for TT carriers and of 26.8 for AA carriers. The increase in BMI across genotypes was mainly restricted to individuals who reported low leisure-time physical activity (P for trend = 0.004, P for interaction = 0.05). CONCLUSION: Our results indicate that high-fat diets and low physical activity levels may accentuate the susceptibility to obesity by the FTO variant. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1483888
- author
- Sonestedt, Emily
LU
; Roos, Charlotta
LU
; Gullberg, Bo
LU
; Ericson, Ulrika
LU
; Wirfält, Elisabet
LU
and Orho-Melander, Marju
LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The American journal of clinical nutrition
- volume
- 90
- pages
- 1418 - 1425
- publisher
- Elsevier
- external identifiers
-
- wos:000270959500040
- pmid:19726594
- scopus:70350686380
- ISSN
- 1938-3207
- DOI
- 10.3945/ajcn.2009.27958
- language
- English
- LU publication?
- yes
- id
- b5957bb7-b667-4a47-b469-21e6c7e586df (old id 1483888)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19726594?dopt=Abstract
- date added to LUP
- 2016-04-04 09:03:47
- date last changed
- 2025-01-06 03:35:06
@article{b5957bb7-b667-4a47-b469-21e6c7e586df,
abstract = {{BACKGROUND: The fat mass and obesity-associated gene (FTO) has been shown to be associated with obesity and to influence appetite regulation. OBJECTIVE: The aim was to examine whether dietary factors (macronutrient and fiber intakes) and leisure-time physical activity modify the association between genetic variation in FTO and body mass index (BMI; in kg/m(2)). DESIGN: A cross-sectional study examined 4839 subjects in the population-based Malmö Diet and Cancer study with dietary data (from a modified diet history method) and information on the genetic variant FTO (rs9939609). Direct anthropometric measures were made, and leisure-time physical activity was determined from the duration participants spent on 18 different physical activities. RESULTS: Significant interactions between energy-adjusted fat intake and FTO genotype (P = 0.04) and between carbohydrate intake and FTO genotype (P = 0.001) on BMI were observed. The observed increase in BMI across FTO genotypes was restricted to those who reported a high-fat diet, with a mean BMI of 25.3 (95% CI: 24.9, 25.6) among TT carriers and of 26.3 (95% CI: 25.8, 26.8) among AA carriers (P = 0.0001). The FTO variant was not associated with a higher BMI among subjects with lower fat intakes (BMI = 25.7 and 25.9 in TT carriers and AA carriers, respectively; P = 0.42). Among individuals with a low-carbohydrate intake, we observed a mean BMI of 25.4 for TT carriers and of 26.8 for AA carriers. The increase in BMI across genotypes was mainly restricted to individuals who reported low leisure-time physical activity (P for trend = 0.004, P for interaction = 0.05). CONCLUSION: Our results indicate that high-fat diets and low physical activity levels may accentuate the susceptibility to obesity by the FTO variant.}},
author = {{Sonestedt, Emily and Roos, Charlotta and Gullberg, Bo and Ericson, Ulrika and Wirfält, Elisabet and Orho-Melander, Marju}},
issn = {{1938-3207}},
language = {{eng}},
pages = {{1418--1425}},
publisher = {{Elsevier}},
series = {{The American journal of clinical nutrition}},
title = {{Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity.}},
url = {{http://dx.doi.org/10.3945/ajcn.2009.27958}},
doi = {{10.3945/ajcn.2009.27958}},
volume = {{90}},
year = {{2009}},
}