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Prognostic significance of chromosome aberrations in high-grade soft tissue sarcomas

Mertens, Fredrik LU ; Strömberg, Ulf LU ; Rydholm, Anders LU ; Gustafson, Pelle LU ; Bauer, Henrik C F ; Brosjo, Otte and Mandahl, Nils LU (2006) In Journal of Clinical Oncology 24(2). p.315-320
Abstract
Purpose To investigate whether previously observed correlations between tumor karyotype and risk of metastases could be reproduced in an independent set of high-grade soft tissue sarcomas (STSs). Patients and Methods In a previous study on high-grade STSs with clonal chromosome aberrations, we identified a number of cytogenetic variables, besides tumor grade and size, that were associated with significantly increased risk of metastases. In the present study, we have tested the predictive value of these cytogenetic variables in a new set of 156 high-grade STSs, all located in the extremities or trunk wall. Results Of the 10 cytogenetic variables that turned out to provide prognostic information in the previous series, encompassing 122 trunk... (More)
Purpose To investigate whether previously observed correlations between tumor karyotype and risk of metastases could be reproduced in an independent set of high-grade soft tissue sarcomas (STSs). Patients and Methods In a previous study on high-grade STSs with clonal chromosome aberrations, we identified a number of cytogenetic variables, besides tumor grade and size, that were associated with significantly increased risk of metastases. In the present study, we have tested the predictive value of these cytogenetic variables in a new set of 156 high-grade STSs, all located in the extremities or trunk wall. Results Of the 10 cytogenetic variables that turned out to provide prognostic information in the previous series, encompassing 122 trunk wall or extremity STSs, three were significantly associated with metastases also in the new series. In a final Cox regression analysis including these three cytogenetic variables, as well as tumor grade and size, on the combined series of 278 high-grade STSs, four parameters were found to be significantly associated with metastasis risk: tumor grade 3, tumor size >= 5 cm, breakpoint in region 1p1, and gain of region 6p1. Conclusion Our findings suggest that independent prognostic information may be gained from cytogenetic analysis of high-grade STS. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Aged, Aged, 80 and over, Chromosome Aberrations, Female, Humans, Male, Middle Aged, Prognosis, Regression Analysis, Sarcoma/genetics
in
Journal of Clinical Oncology
volume
24
issue
2
pages
6 pages
publisher
American Society of Clinical Oncology
external identifiers
  • pmid:16330667
  • wos:000234741700012
  • scopus:33644828028
  • pmid:16330667
ISSN
1527-7755
DOI
10.1200/JCO.2005.03.0999
language
English
LU publication?
yes
id
71950d6c-0faa-4c97-8ef5-383c5915b961 (old id 148876)
date added to LUP
2016-04-01 12:07:01
date last changed
2020-11-23 09:07:59
@article{71950d6c-0faa-4c97-8ef5-383c5915b961,
  abstract     = {Purpose To investigate whether previously observed correlations between tumor karyotype and risk of metastases could be reproduced in an independent set of high-grade soft tissue sarcomas (STSs). Patients and Methods In a previous study on high-grade STSs with clonal chromosome aberrations, we identified a number of cytogenetic variables, besides tumor grade and size, that were associated with significantly increased risk of metastases. In the present study, we have tested the predictive value of these cytogenetic variables in a new set of 156 high-grade STSs, all located in the extremities or trunk wall. Results Of the 10 cytogenetic variables that turned out to provide prognostic information in the previous series, encompassing 122 trunk wall or extremity STSs, three were significantly associated with metastases also in the new series. In a final Cox regression analysis including these three cytogenetic variables, as well as tumor grade and size, on the combined series of 278 high-grade STSs, four parameters were found to be significantly associated with metastasis risk: tumor grade 3, tumor size >= 5 cm, breakpoint in region 1p1, and gain of region 6p1. Conclusion Our findings suggest that independent prognostic information may be gained from cytogenetic analysis of high-grade STS.},
  author       = {Mertens, Fredrik and Strömberg, Ulf and Rydholm, Anders and Gustafson, Pelle and Bauer, Henrik C F and Brosjo, Otte and Mandahl, Nils},
  issn         = {1527-7755},
  language     = {eng},
  number       = {2},
  pages        = {315--320},
  publisher    = {American Society of Clinical Oncology},
  series       = {Journal of Clinical Oncology},
  title        = {Prognostic significance of chromosome aberrations in high-grade soft tissue sarcomas},
  url          = {http://dx.doi.org/10.1200/JCO.2005.03.0999},
  doi          = {10.1200/JCO.2005.03.0999},
  volume       = {24},
  year         = {2006},
}