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Functional properties of the human ventral mesencephalic neural stem cell line hVM1.

Tønnesen, Jan; Seiz, Emma Gonzalez; Ramos, Milagros; Lindvall, Olle LU ; Martinez-Serrano, Alberto and Kokaia, Merab LU (2010) In Experimental Neurology 223. p.653-656
Abstract
The human fetal ventral mesencephalon-derived stem cell line, hVM1, yields high number of tyrosine hydroxylase-expressing presumed dopaminergic neurons upon in vitro differentiation. Here we report that cells generated from this line differentiate into a neuronal phenotype, express electrophysiological properties of functional neurons and respond to neurotransmitters in vitro. However, the electrophysiological properties are immature and the cells require longer maturation time than possible under in vitro conditions.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Experimental Neurology
volume
223
pages
653 - 656
publisher
Academic Press
external identifiers
  • wos:000277743700046
  • pmid:20122925
  • scopus:77952554364
ISSN
0014-4886
DOI
10.1016/j.expneurol.2010.01.013
language
English
LU publication?
yes
id
8b53ad3b-0fee-4bed-b68f-42e1b3eb6206 (old id 1553062)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20122925?dopt=Abstract
date added to LUP
2010-03-02 15:48:30
date last changed
2018-05-29 10:00:00
@article{8b53ad3b-0fee-4bed-b68f-42e1b3eb6206,
  abstract     = {The human fetal ventral mesencephalon-derived stem cell line, hVM1, yields high number of tyrosine hydroxylase-expressing presumed dopaminergic neurons upon in vitro differentiation. Here we report that cells generated from this line differentiate into a neuronal phenotype, express electrophysiological properties of functional neurons and respond to neurotransmitters in vitro. However, the electrophysiological properties are immature and the cells require longer maturation time than possible under in vitro conditions.},
  author       = {Tønnesen, Jan and Seiz, Emma Gonzalez and Ramos, Milagros and Lindvall, Olle and Martinez-Serrano, Alberto and Kokaia, Merab},
  issn         = {0014-4886},
  language     = {eng},
  pages        = {653--656},
  publisher    = {Academic Press},
  series       = {Experimental Neurology},
  title        = {Functional properties of the human ventral mesencephalic neural stem cell line hVM1.},
  url          = {http://dx.doi.org/10.1016/j.expneurol.2010.01.013},
  volume       = {223},
  year         = {2010},
}