No association between inhaled corticosteroids and whole body DXA in postmenopausal women.
(2006) In Pharmacoepidemiology and Drug Safety 15(May 22). p.527-535- Abstract
- Purpose Postmenopausal women treated with corticosteroids are regarded as a high-risk group due to the effect of both natural bone loss and possible adverse effects of treatment with inhaled corticosteroids (IC). Objective To compare bone mineral density (BMD) in postmenopausal women exposed only to IC (IC group, n = 106) with that of BMD in women not exposed to corticosteroids (n = 124) and women exposed to oral and/or intra-articular injections in addition to inhaled corticosteroids (OC group, n = 3 1). The women were recruited from a population-based prospective cohort study. Methods Dual X-ray absorptiometry (DXA) technique was used to measure BMD in whole body, spine, pelvis and lower extremities. A health questionnaire and an... (More)
- Purpose Postmenopausal women treated with corticosteroids are regarded as a high-risk group due to the effect of both natural bone loss and possible adverse effects of treatment with inhaled corticosteroids (IC). Objective To compare bone mineral density (BMD) in postmenopausal women exposed only to IC (IC group, n = 106) with that of BMD in women not exposed to corticosteroids (n = 124) and women exposed to oral and/or intra-articular injections in addition to inhaled corticosteroids (OC group, n = 3 1). The women were recruited from a population-based prospective cohort study. Methods Dual X-ray absorptiometry (DXA) technique was used to measure BMD in whole body, spine, pelvis and lower extremities. A health questionnaire and an interview about past and present medication use were used. Results The mean duration and dose of IC were 9.5 +/- 4.5 years and 615 mu g daily. Whole body BMD did not significantly differ between the IC group (1.103 g/cm(2)) and the unexposed group (1.087 g/cm(2)). Within the IC group, BMD stratified for cumulative dose of IC, duration or current dose above or below 800 jig did not differ. Z-score BMD for tertiles did not differ when comparing the IC and OC groups. Conclusion No difference in BMD was noted between postmenopausal women exposed to inhaled corticosteroids and unexposed controls nor was there any dose response relationship between inhaled corticosteroid therapy and BMD. Copyright (c) 2006 John Wiley & Sons, Ltd. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/156626
- author
- Elmståhl, Sölve LU ; Ekström, Henrik LU ; Johnell, Olof LU ; Gerhardsson de Verdier, Maria and Norjavaara, Ensio
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- bone mineral density, cohort study, postmenopausal, inhaled corticosteroids
- in
- Pharmacoepidemiology and Drug Safety
- volume
- 15
- issue
- May 22
- pages
- 527 - 535
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000239289200013
- scopus:33746594092
- ISSN
- 1053-8569
- DOI
- 10.1002/pds.1255
- language
- English
- LU publication?
- yes
- id
- f813636a-6ba5-4009-b55d-83254c66fe2a (old id 156626)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16715539&dopt=Abstract
- date added to LUP
- 2016-04-01 11:54:32
- date last changed
- 2024-01-08 01:06:18
@article{f813636a-6ba5-4009-b55d-83254c66fe2a,
abstract = {{Purpose Postmenopausal women treated with corticosteroids are regarded as a high-risk group due to the effect of both natural bone loss and possible adverse effects of treatment with inhaled corticosteroids (IC). Objective To compare bone mineral density (BMD) in postmenopausal women exposed only to IC (IC group, n = 106) with that of BMD in women not exposed to corticosteroids (n = 124) and women exposed to oral and/or intra-articular injections in addition to inhaled corticosteroids (OC group, n = 3 1). The women were recruited from a population-based prospective cohort study. Methods Dual X-ray absorptiometry (DXA) technique was used to measure BMD in whole body, spine, pelvis and lower extremities. A health questionnaire and an interview about past and present medication use were used. Results The mean duration and dose of IC were 9.5 +/- 4.5 years and 615 mu g daily. Whole body BMD did not significantly differ between the IC group (1.103 g/cm(2)) and the unexposed group (1.087 g/cm(2)). Within the IC group, BMD stratified for cumulative dose of IC, duration or current dose above or below 800 jig did not differ. Z-score BMD for tertiles did not differ when comparing the IC and OC groups. Conclusion No difference in BMD was noted between postmenopausal women exposed to inhaled corticosteroids and unexposed controls nor was there any dose response relationship between inhaled corticosteroid therapy and BMD. Copyright (c) 2006 John Wiley & Sons, Ltd.}},
author = {{Elmståhl, Sölve and Ekström, Henrik and Johnell, Olof and Gerhardsson de Verdier, Maria and Norjavaara, Ensio}},
issn = {{1053-8569}},
keywords = {{bone mineral density; cohort study; postmenopausal; inhaled corticosteroids}},
language = {{eng}},
number = {{May 22}},
pages = {{527--535}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Pharmacoepidemiology and Drug Safety}},
title = {{No association between inhaled corticosteroids and whole body DXA in postmenopausal women.}},
url = {{http://dx.doi.org/10.1002/pds.1255}},
doi = {{10.1002/pds.1255}},
volume = {{15}},
year = {{2006}},
}