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No association between inhaled corticosteroids and whole body DXA in postmenopausal women.

Elmståhl, Sölve LU ; Ekström, Henrik LU ; Johnell, Olof LU ; Gerhardsson de Verdier, Maria and Norjavaara, Ensio (2006) In Pharmacoepidemiology and Drug Safety 15(May 22). p.527-535
Abstract
Purpose Postmenopausal women treated with corticosteroids are regarded as a high-risk group due to the effect of both natural bone loss and possible adverse effects of treatment with inhaled corticosteroids (IC). Objective To compare bone mineral density (BMD) in postmenopausal women exposed only to IC (IC group, n = 106) with that of BMD in women not exposed to corticosteroids (n = 124) and women exposed to oral and/or intra-articular injections in addition to inhaled corticosteroids (OC group, n = 3 1). The women were recruited from a population-based prospective cohort study. Methods Dual X-ray absorptiometry (DXA) technique was used to measure BMD in whole body, spine, pelvis and lower extremities. A health questionnaire and an... (More)
Purpose Postmenopausal women treated with corticosteroids are regarded as a high-risk group due to the effect of both natural bone loss and possible adverse effects of treatment with inhaled corticosteroids (IC). Objective To compare bone mineral density (BMD) in postmenopausal women exposed only to IC (IC group, n = 106) with that of BMD in women not exposed to corticosteroids (n = 124) and women exposed to oral and/or intra-articular injections in addition to inhaled corticosteroids (OC group, n = 3 1). The women were recruited from a population-based prospective cohort study. Methods Dual X-ray absorptiometry (DXA) technique was used to measure BMD in whole body, spine, pelvis and lower extremities. A health questionnaire and an interview about past and present medication use were used. Results The mean duration and dose of IC were 9.5 +/- 4.5 years and 615 mu g daily. Whole body BMD did not significantly differ between the IC group (1.103 g/cm(2)) and the unexposed group (1.087 g/cm(2)). Within the IC group, BMD stratified for cumulative dose of IC, duration or current dose above or below 800 jig did not differ. Z-score BMD for tertiles did not differ when comparing the IC and OC groups. Conclusion No difference in BMD was noted between postmenopausal women exposed to inhaled corticosteroids and unexposed controls nor was there any dose response relationship between inhaled corticosteroid therapy and BMD. Copyright (c) 2006 John Wiley & Sons, Ltd. (Less)
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author
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type
Contribution to journal
publication status
published
subject
keywords
bone mineral density, cohort study, postmenopausal, inhaled corticosteroids
in
Pharmacoepidemiology and Drug Safety
volume
15
issue
May 22
pages
527 - 535
publisher
John Wiley and Sons
external identifiers
  • wos:000239289200013
  • scopus:33746594092
ISSN
1053-8569
DOI
10.1002/pds.1255
language
English
LU publication?
yes
id
f813636a-6ba5-4009-b55d-83254c66fe2a (old id 156626)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16715539&dopt=Abstract
date added to LUP
2016-04-01 11:54:32
date last changed
2021-06-30 04:02:46
@article{f813636a-6ba5-4009-b55d-83254c66fe2a,
  abstract     = {Purpose Postmenopausal women treated with corticosteroids are regarded as a high-risk group due to the effect of both natural bone loss and possible adverse effects of treatment with inhaled corticosteroids (IC). Objective To compare bone mineral density (BMD) in postmenopausal women exposed only to IC (IC group, n = 106) with that of BMD in women not exposed to corticosteroids (n = 124) and women exposed to oral and/or intra-articular injections in addition to inhaled corticosteroids (OC group, n = 3 1). The women were recruited from a population-based prospective cohort study. Methods Dual X-ray absorptiometry (DXA) technique was used to measure BMD in whole body, spine, pelvis and lower extremities. A health questionnaire and an interview about past and present medication use were used. Results The mean duration and dose of IC were 9.5 +/- 4.5 years and 615 mu g daily. Whole body BMD did not significantly differ between the IC group (1.103 g/cm(2)) and the unexposed group (1.087 g/cm(2)). Within the IC group, BMD stratified for cumulative dose of IC, duration or current dose above or below 800 jig did not differ. Z-score BMD for tertiles did not differ when comparing the IC and OC groups. Conclusion No difference in BMD was noted between postmenopausal women exposed to inhaled corticosteroids and unexposed controls nor was there any dose response relationship between inhaled corticosteroid therapy and BMD. Copyright (c) 2006 John Wiley & Sons, Ltd.},
  author       = {Elmståhl, Sölve and Ekström, Henrik and Johnell, Olof and Gerhardsson de Verdier, Maria and Norjavaara, Ensio},
  issn         = {1053-8569},
  language     = {eng},
  number       = {May 22},
  pages        = {527--535},
  publisher    = {John Wiley and Sons},
  series       = {Pharmacoepidemiology and Drug Safety},
  title        = {No association between inhaled corticosteroids and whole body DXA in postmenopausal women.},
  url          = {http://dx.doi.org/10.1002/pds.1255},
  doi          = {10.1002/pds.1255},
  volume       = {15},
  year         = {2006},
}