Decreased expression of brain-derived neurotrophic factor in BDNF(+/-) mice is associated with enhanced recovery of motor performance and increased neuroblast number following experimental stroke.
(2006) In Journal of Neuroscience Research 84(3). p.626-631- Abstract
- Brain-derived neurotrophic factor (BDNF) is involved in brain plasticity and neuronal survival. Generally, BDNF enhances synaptic activity and neurite growth, although the effect of BDNF on neuronal survival and brain plasticity following injury is equivocal. Housing rats in an enriched environment after experimental stroke enhances recovery of sensory-motor function, which is associated with a decrease in the BDNF mRNA and protein levels. We used BDNF+/- mice and wild-type littermate mice to investigate whether the decrease in the brain levels of BDNF affected motor function or infarct volume following transient occlusion of the middle cerebral artery (tMCAO) for 40 min. We found that the BDNF+/- mice had a significantly improved motor... (More)
- Brain-derived neurotrophic factor (BDNF) is involved in brain plasticity and neuronal survival. Generally, BDNF enhances synaptic activity and neurite growth, although the effect of BDNF on neuronal survival and brain plasticity following injury is equivocal. Housing rats in an enriched environment after experimental stroke enhances recovery of sensory-motor function, which is associated with a decrease in the BDNF mRNA and protein levels. We used BDNF+/- mice and wild-type littermate mice to investigate whether the decrease in the brain levels of BDNF affected motor function or infarct volume following transient occlusion of the middle cerebral artery (tMCAO) for 40 min. We found that the BDNF+/- mice had a significantly improved motor function on the rotating pole test 2 weeks after tMCAO compared with wild-type mice. When intermittently exposed to an enriched environment following tMCAO, the wild-type mice improved motor function to the same degree as BDNF mice. There was no effect of BDNF reduction on infarct volume. Neurogenesis is induced following experimental stroke, and in the striatum of BDNF+/- mice significantly increased numbers of neuroblasts compared with wildtype mice were seen, both in standard and in enriched conditions. We conclude that decreasing brain levels of BDNF enhances the recovery of function following experimental stroke. (c) 2006 Wiley-Liss, Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/158337
- author
- Nygren, Josefine LU ; Kokaia, Merab LU and Wieloch, Tadeusz LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- neurotrophic factor, focal ischemia, brain-derived, neurogenesis, enriched environment
- in
- Journal of Neuroscience Research
- volume
- 84
- issue
- 3
- pages
- 626 - 631
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:16770774
- wos:000239584700016
- scopus:33747020589
- ISSN
- 1097-4547
- DOI
- 10.1002/jnr.20956
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Wallenberg Neuroscience Centre, Lund (0131000110), Laboratory for Experimental Brain Research (013041000), Neurology, Lund (013027000)
- id
- 2ad081cb-7724-491b-8518-6ef2b422d417 (old id 158337)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16770774&dopt=Abstract
- date added to LUP
- 2016-04-01 15:35:28
- date last changed
- 2022-02-27 07:46:48
@article{2ad081cb-7724-491b-8518-6ef2b422d417,
abstract = {{Brain-derived neurotrophic factor (BDNF) is involved in brain plasticity and neuronal survival. Generally, BDNF enhances synaptic activity and neurite growth, although the effect of BDNF on neuronal survival and brain plasticity following injury is equivocal. Housing rats in an enriched environment after experimental stroke enhances recovery of sensory-motor function, which is associated with a decrease in the BDNF mRNA and protein levels. We used BDNF+/- mice and wild-type littermate mice to investigate whether the decrease in the brain levels of BDNF affected motor function or infarct volume following transient occlusion of the middle cerebral artery (tMCAO) for 40 min. We found that the BDNF+/- mice had a significantly improved motor function on the rotating pole test 2 weeks after tMCAO compared with wild-type mice. When intermittently exposed to an enriched environment following tMCAO, the wild-type mice improved motor function to the same degree as BDNF mice. There was no effect of BDNF reduction on infarct volume. Neurogenesis is induced following experimental stroke, and in the striatum of BDNF+/- mice significantly increased numbers of neuroblasts compared with wildtype mice were seen, both in standard and in enriched conditions. We conclude that decreasing brain levels of BDNF enhances the recovery of function following experimental stroke. (c) 2006 Wiley-Liss, Inc.}},
author = {{Nygren, Josefine and Kokaia, Merab and Wieloch, Tadeusz}},
issn = {{1097-4547}},
keywords = {{neurotrophic factor; focal ischemia; brain-derived; neurogenesis; enriched environment}},
language = {{eng}},
number = {{3}},
pages = {{626--631}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Journal of Neuroscience Research}},
title = {{Decreased expression of brain-derived neurotrophic factor in BDNF(+/-) mice is associated with enhanced recovery of motor performance and increased neuroblast number following experimental stroke.}},
url = {{http://dx.doi.org/10.1002/jnr.20956}},
doi = {{10.1002/jnr.20956}},
volume = {{84}},
year = {{2006}},
}