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Decreased neutrophil function in newly diagnosed multiple myeloma patients is restored with lenalidomide therapy

Askman, Sandra LU ; Westerlund, Julia LU ; Pettersson, Åsa LU ; Hellmark, Thomas LU orcid ; Johansson, Åsa LU ; Wichert, Stina LU orcid and Hansson, Markus LU orcid (2024) In European Journal of Haematology
Abstract

OBJECTIVES: Bacterial infections are common and a major cause of morbidity and mortality in multiple myeloma (MM). We have investigated the function of polymorphonuclear leukocyte (PMN), the immune system's first line of defense against bacteria, in peripheral blood (PB) and bone marrow (BM) samples from patients with newly diagnosed MM (NDMM), smoldering MM (SMM), monoclonal gammopathy of undetermined significance (MGUS) and healthy controls.

METHODS: Phagocytosis and oxidative burst in PMN cells from patients and healthy donors were investigated using PhagoTest and PhagoBurst assay.

RESULTS: PMN from NDMM, SMM, and MGUS patients had reduced phagocytosis and oxidative burst ability compared with healthy controls. The... (More)

OBJECTIVES: Bacterial infections are common and a major cause of morbidity and mortality in multiple myeloma (MM). We have investigated the function of polymorphonuclear leukocyte (PMN), the immune system's first line of defense against bacteria, in peripheral blood (PB) and bone marrow (BM) samples from patients with newly diagnosed MM (NDMM), smoldering MM (SMM), monoclonal gammopathy of undetermined significance (MGUS) and healthy controls.

METHODS: Phagocytosis and oxidative burst in PMN cells from patients and healthy donors were investigated using PhagoTest and PhagoBurst assay.

RESULTS: PMN from NDMM, SMM, and MGUS patients had reduced phagocytosis and oxidative burst ability compared with healthy controls. The dysfunction was most prominent in BM samples from MM, SMM, and MGUS patients. Importantly the reduced phagocytosis in MM patients was restored in patients on lenalidomide therapy. Consistently the ability of Escherichia coli stimulated oxidative burst in BM was reduced for the MM, SMM, and MGUS cohort in contrast to the healthy controls and the patients on lenalidomide treatment.

CONCLUSION: Our results show that MM patients have neutrophil dysfunction that could contribute to susceptibility for bacterial infections and that lenalidomide therapy was associated with restored PMN function.

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author
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organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
European Journal of Haematology
publisher
Wiley-Blackwell
external identifiers
  • scopus:85189635410
  • pmid:38553844
ISSN
1600-0609
DOI
10.1111/ejh.14200
language
English
LU publication?
yes
additional info
© 2024 The Authors. European Journal of Haematology published by John Wiley & Sons Ltd.
id
15cd5b63-ab82-4ef8-9dc1-70a5e5b945b7
date added to LUP
2024-04-04 22:18:36
date last changed
2024-04-23 14:45:55
@article{15cd5b63-ab82-4ef8-9dc1-70a5e5b945b7,
  abstract     = {{<p>OBJECTIVES: Bacterial infections are common and a major cause of morbidity and mortality in multiple myeloma (MM). We have investigated the function of polymorphonuclear leukocyte (PMN), the immune system's first line of defense against bacteria, in peripheral blood (PB) and bone marrow (BM) samples from patients with newly diagnosed MM (NDMM), smoldering MM (SMM), monoclonal gammopathy of undetermined significance (MGUS) and healthy controls.</p><p>METHODS: Phagocytosis and oxidative burst in PMN cells from patients and healthy donors were investigated using PhagoTest and PhagoBurst assay.</p><p>RESULTS: PMN from NDMM, SMM, and MGUS patients had reduced phagocytosis and oxidative burst ability compared with healthy controls. The dysfunction was most prominent in BM samples from MM, SMM, and MGUS patients. Importantly the reduced phagocytosis in MM patients was restored in patients on lenalidomide therapy. Consistently the ability of Escherichia coli stimulated oxidative burst in BM was reduced for the MM, SMM, and MGUS cohort in contrast to the healthy controls and the patients on lenalidomide treatment.</p><p>CONCLUSION: Our results show that MM patients have neutrophil dysfunction that could contribute to susceptibility for bacterial infections and that lenalidomide therapy was associated with restored PMN function.</p>}},
  author       = {{Askman, Sandra and Westerlund, Julia and Pettersson, Åsa and Hellmark, Thomas and Johansson, Åsa and Wichert, Stina and Hansson, Markus}},
  issn         = {{1600-0609}},
  language     = {{eng}},
  month        = {{03}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{European Journal of Haematology}},
  title        = {{Decreased neutrophil function in newly diagnosed multiple myeloma patients is restored with lenalidomide therapy}},
  url          = {{http://dx.doi.org/10.1111/ejh.14200}},
  doi          = {{10.1111/ejh.14200}},
  year         = {{2024}},
}