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Evaluation of direct oral anticoagulants and vitamin K antagonists in mesenteric venous thrombosis

Salim, Saman LU ; Ekberg, Olle LU ; Elf, Johan LU ; Zarrouk, Moncef LU ; Gottsäter, Anders LU and Acosta, Stefan LU (2018) In Phlebology
Abstract

Background/aim: Mesenteric venous thrombosis is a rare lethal disease. The main aim of the present study was to evaluate clinical efficacy and safety of direct oral anticoagulants and vitamin K antagonists in mesenteric venous thrombosis patients. Methods: Retrospective study of 102 mesenteric venous thrombosis patients treated between 2004 and 2017 at a center with a conservative medical first approach. Median clinical follow-up was 4 years. Results: Computed tomography showed successful recanalization of thrombosis in 71% of patients on vitamin K antagonists and 69% of patients on direct oral anticoagulants (p = 0.88). Overall major and esophageal variceal bleeding rate was 14.7% and 2.9%, respectively. No difference in major bleeding... (More)

Background/aim: Mesenteric venous thrombosis is a rare lethal disease. The main aim of the present study was to evaluate clinical efficacy and safety of direct oral anticoagulants and vitamin K antagonists in mesenteric venous thrombosis patients. Methods: Retrospective study of 102 mesenteric venous thrombosis patients treated between 2004 and 2017 at a center with a conservative medical first approach. Median clinical follow-up was 4 years. Results: Computed tomography showed successful recanalization of thrombosis in 71% of patients on vitamin K antagonists and 69% of patients on direct oral anticoagulants (p = 0.88). Overall major and esophageal variceal bleeding rate was 14.7% and 2.9%, respectively. No difference in major bleeding (p = 0.54) was found between vitamin K antagonists and direct oral anticoagulants. No mesenteric venous thrombosis recurrence occurred during follow-up, and one venous thromboembolism occurred after cessation of anticoagulation. Conclusion: Anticoagulation with direct oral anticoagulants and vitamin K antagonists was efficient in patients with mesenteric venous thrombosis. Bleeding complications was a concern during treatment in both groups.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
anticoagulation, computed tomography, direct oral anticoagulants, efficacy, Mesenteric venous thrombosis, recanalization, safety
in
Phlebology
publisher
Springer
external identifiers
  • scopus:85047928818
ISSN
0268-3555
DOI
10.1177/0268355518779517
language
English
LU publication?
yes
id
15ec7fd4-f3e5-4035-a34e-0f6d0a63b8b0
date added to LUP
2018-06-14 16:08:46
date last changed
2018-06-15 03:00:03
@article{15ec7fd4-f3e5-4035-a34e-0f6d0a63b8b0,
  abstract     = {<p>Background/aim: Mesenteric venous thrombosis is a rare lethal disease. The main aim of the present study was to evaluate clinical efficacy and safety of direct oral anticoagulants and vitamin K antagonists in mesenteric venous thrombosis patients. Methods: Retrospective study of 102 mesenteric venous thrombosis patients treated between 2004 and 2017 at a center with a conservative medical first approach. Median clinical follow-up was 4 years. Results: Computed tomography showed successful recanalization of thrombosis in 71% of patients on vitamin K antagonists and 69% of patients on direct oral anticoagulants (p = 0.88). Overall major and esophageal variceal bleeding rate was 14.7% and 2.9%, respectively. No difference in major bleeding (p = 0.54) was found between vitamin K antagonists and direct oral anticoagulants. No mesenteric venous thrombosis recurrence occurred during follow-up, and one venous thromboembolism occurred after cessation of anticoagulation. Conclusion: Anticoagulation with direct oral anticoagulants and vitamin K antagonists was efficient in patients with mesenteric venous thrombosis. Bleeding complications was a concern during treatment in both groups.</p>},
  author       = {Salim, Saman and Ekberg, Olle and Elf, Johan and Zarrouk, Moncef and Gottsäter, Anders and Acosta, Stefan},
  issn         = {0268-3555},
  keyword      = {anticoagulation,computed tomography,direct oral anticoagulants,efficacy,Mesenteric venous thrombosis,recanalization,safety},
  language     = {eng},
  month        = {01},
  publisher    = {Springer},
  series       = {Phlebology},
  title        = {Evaluation of direct oral anticoagulants and vitamin K antagonists in mesenteric venous thrombosis},
  url          = {http://dx.doi.org/10.1177/0268355518779517},
  year         = {2018},
}