Advanced

Evaluation of direct oral anticoagulants and vitamin K antagonists in mesenteric venous thrombosis

Salim, Saman LU ; Ekberg, Olle LU ; Elf, Johan LU ; Zarrouk, Moncef LU ; Gottsäter, Anders LU and Acosta, Stefan LU (2019) In Phlebology 34(3). p.171-178
Abstract

Background/aim: Mesenteric venous thrombosis is a rare lethal disease. The main aim of the present study was to evaluate clinical efficacy and safety of direct oral anticoagulants and vitamin K antagonists in mesenteric venous thrombosis patients. Methods: Retrospective study of 102 mesenteric venous thrombosis patients treated between 2004 and 2017 at a center with a conservative medical first approach. Median clinical follow-up was 4 years. Results: Computed tomography showed successful recanalization of thrombosis in 71% of patients on vitamin K antagonists and 69% of patients on direct oral anticoagulants (p = 0.88). Overall major and esophageal variceal bleeding rate was 14.7% and 2.9%, respectively. No difference in major bleeding... (More)

Background/aim: Mesenteric venous thrombosis is a rare lethal disease. The main aim of the present study was to evaluate clinical efficacy and safety of direct oral anticoagulants and vitamin K antagonists in mesenteric venous thrombosis patients. Methods: Retrospective study of 102 mesenteric venous thrombosis patients treated between 2004 and 2017 at a center with a conservative medical first approach. Median clinical follow-up was 4 years. Results: Computed tomography showed successful recanalization of thrombosis in 71% of patients on vitamin K antagonists and 69% of patients on direct oral anticoagulants (p = 0.88). Overall major and esophageal variceal bleeding rate was 14.7% and 2.9%, respectively. No difference in major bleeding (p = 0.54) was found between vitamin K antagonists and direct oral anticoagulants. No mesenteric venous thrombosis recurrence occurred during follow-up, and one venous thromboembolism occurred after cessation of anticoagulation. Conclusion: Anticoagulation with direct oral anticoagulants and vitamin K antagonists was efficient in patients with mesenteric venous thrombosis. Bleeding complications was a concern during treatment in both groups.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
anticoagulation, computed tomography, direct oral anticoagulants, efficacy, Mesenteric venous thrombosis, recanalization, safety
in
Phlebology
volume
34
issue
3
pages
171 - 178
publisher
Springer
external identifiers
  • scopus:85047928818
  • pmid:29848218
ISSN
0268-3555
DOI
10.1177/0268355518779517
language
English
LU publication?
yes
id
15ec7fd4-f3e5-4035-a34e-0f6d0a63b8b0
date added to LUP
2018-06-14 16:08:46
date last changed
2020-07-01 04:37:54
@article{15ec7fd4-f3e5-4035-a34e-0f6d0a63b8b0,
  abstract     = {<p>Background/aim: Mesenteric venous thrombosis is a rare lethal disease. The main aim of the present study was to evaluate clinical efficacy and safety of direct oral anticoagulants and vitamin K antagonists in mesenteric venous thrombosis patients. Methods: Retrospective study of 102 mesenteric venous thrombosis patients treated between 2004 and 2017 at a center with a conservative medical first approach. Median clinical follow-up was 4 years. Results: Computed tomography showed successful recanalization of thrombosis in 71% of patients on vitamin K antagonists and 69% of patients on direct oral anticoagulants (p = 0.88). Overall major and esophageal variceal bleeding rate was 14.7% and 2.9%, respectively. No difference in major bleeding (p = 0.54) was found between vitamin K antagonists and direct oral anticoagulants. No mesenteric venous thrombosis recurrence occurred during follow-up, and one venous thromboembolism occurred after cessation of anticoagulation. Conclusion: Anticoagulation with direct oral anticoagulants and vitamin K antagonists was efficient in patients with mesenteric venous thrombosis. Bleeding complications was a concern during treatment in both groups.</p>},
  author       = {Salim, Saman and Ekberg, Olle and Elf, Johan and Zarrouk, Moncef and Gottsäter, Anders and Acosta, Stefan},
  issn         = {0268-3555},
  language     = {eng},
  number       = {3},
  pages        = {171--178},
  publisher    = {Springer},
  series       = {Phlebology},
  title        = {Evaluation of direct oral anticoagulants and vitamin K antagonists in mesenteric venous thrombosis},
  url          = {http://dx.doi.org/10.1177/0268355518779517},
  doi          = {10.1177/0268355518779517},
  volume       = {34},
  year         = {2019},
}