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Anthropometric measures and epithelial ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition

Lahmann, Petra H.; Cust, Anne E.; Friedenreich, Christine M.; Schulz, Mandy; Lukanova, Annekatrin; Kaaks, Rudolf; Lundin, Eva; Tjonneland, Anne; Halkjaer, Jytte and Severinsen, Marianne Tang, et al. (2010) In International Journal of Cancer 126(10). p.2404-2415
Abstract
We examined the associations of measured anthropometric factors, including general and central adiposity and height, with ovarian cancer risk. We also investigated these associations by menopausal status and for specific histological subtypes. Among 226,798 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, there were 611 incident cases of primary, malignant, epithelial ovarian cancer diagnosed during a mean 8.9 years of follow-up. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (as), adjusted for potential confounders. Compared to women with body mass index (BMI) < 25 kg/m(2), obesity (BMI >= 30 kg/m(2)) was associated with excess ovarian... (More)
We examined the associations of measured anthropometric factors, including general and central adiposity and height, with ovarian cancer risk. We also investigated these associations by menopausal status and for specific histological subtypes. Among 226,798 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, there were 611 incident cases of primary, malignant, epithelial ovarian cancer diagnosed during a mean 8.9 years of follow-up. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (as), adjusted for potential confounders. Compared to women with body mass index (BMI) < 25 kg/m(2), obesity (BMI >= 30 kg/m(2)) was associated with excess ovarian cancer risk for all women combined (HR = 1.33, 95% Cl = 1.05-1.68; p(trend) = 0.02) and postmenopausal women (HR = 1.59, 95% Cl = 1.20-2.10; p(trend) = 0.001), but the association was weaker for premenopausal women (HR = 1.16, 95% Cl = 0.65-2.06; p(trend) = 0.65). Neither height or weight gain, nor BMI-adjusted measures of fat distribution assessed by waist circumference, waist-hip ratio (WHR) or hip circumference were associated with overall risk. WHR was related to increased risk of mucinous tumors (BMI-adjusted HR per 0.05 unit increment = 1.17, 95% Cl = 1.00-1.38). For all women combined, no other significant associations with risk were observed for specific histological subtypes. This large, prospective study provides evidence that obesity is an important modifiable risk factor for epithelial ovarian cancer, particularly among postmenopausal women. (Less)
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publication status
published
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keywords
menopausal status, obesity, etiology, anthropometry, ovarian cancer
in
International Journal of Cancer
volume
126
issue
10
pages
2404 - 2415
publisher
John Wiley & Sons
external identifiers
  • wos:000276928700014
  • scopus:77951249951
ISSN
0020-7136
DOI
10.1002/ijc.24952
language
English
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yes
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4c08a734-b919-4180-aed4-e20436289df0 (old id 1601752)
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2010-05-20 10:14:23
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@article{4c08a734-b919-4180-aed4-e20436289df0,
  abstract     = {We examined the associations of measured anthropometric factors, including general and central adiposity and height, with ovarian cancer risk. We also investigated these associations by menopausal status and for specific histological subtypes. Among 226,798 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, there were 611 incident cases of primary, malignant, epithelial ovarian cancer diagnosed during a mean 8.9 years of follow-up. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (as), adjusted for potential confounders. Compared to women with body mass index (BMI) &lt; 25 kg/m(2), obesity (BMI &gt;= 30 kg/m(2)) was associated with excess ovarian cancer risk for all women combined (HR = 1.33, 95% Cl = 1.05-1.68; p(trend) = 0.02) and postmenopausal women (HR = 1.59, 95% Cl = 1.20-2.10; p(trend) = 0.001), but the association was weaker for premenopausal women (HR = 1.16, 95% Cl = 0.65-2.06; p(trend) = 0.65). Neither height or weight gain, nor BMI-adjusted measures of fat distribution assessed by waist circumference, waist-hip ratio (WHR) or hip circumference were associated with overall risk. WHR was related to increased risk of mucinous tumors (BMI-adjusted HR per 0.05 unit increment = 1.17, 95% Cl = 1.00-1.38). For all women combined, no other significant associations with risk were observed for specific histological subtypes. This large, prospective study provides evidence that obesity is an important modifiable risk factor for epithelial ovarian cancer, particularly among postmenopausal women.},
  author       = {Lahmann, Petra H. and Cust, Anne E. and Friedenreich, Christine M. and Schulz, Mandy and Lukanova, Annekatrin and Kaaks, Rudolf and Lundin, Eva and Tjonneland, Anne and Halkjaer, Jytte and Severinsen, Marianne Tang and Overvad, Kim and Fournier, Agnes and Chabbert-Buffet, Nathalie and Clavel-Chapelon, Francoise and Dossus, Laure and Pischon, Tobias and Boeing, Heiner and Trichopoulou, Antonia and Lagiou, Pagona and Naska, Androniki and Palli, Domenico and Grioni, Sara and Mattiello, Amalia and Tumino, Rosario and Sacerdote, Carlotta and Redondo, Maria-Luisa and Jakszyn, Paula and Sanchez, Maria-Jose and Tormo, Maria-Jose and Ardanaz, Eva and Arriola, Larraitz and Manjer, Jonas and Jirström, Karin and Bueno-de-Mesquita, H. Bas and May, Anne M. and Peeters, Petra H. M. and Onland-Moret, N. Charlotte and Bingham, Sheila and Khaw, Kay-Tee and Allen, Naomi E. and Spencer, Elizabeth and Rinaldi, Sabina and Slimani, Nadia and Chajes, Veronique and Michaud, Dominique and Norat, Teresa and Riboli, Elio},
  issn         = {0020-7136},
  keyword      = {menopausal status,obesity,etiology,anthropometry,ovarian cancer},
  language     = {eng},
  number       = {10},
  pages        = {2404--2415},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Anthropometric measures and epithelial ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1002/ijc.24952},
  volume       = {126},
  year         = {2010},
}