Earlier Apgar score increase in severely depressed term infants cared for in Swedish level III units with 40% oxygen versus 100% oxygen resuscitation strategies: a population-based register study.
(2006) In Pediatrics 118(6). p.1798-1804- Abstract
- OBJECTIVES. The aim of this study was to evaluate whether a resuscitation strategy based on administration of 40% oxygen influences mortality rates and rates of improvement in 5-minute Apgar scores, compared with a strategy based on 100% oxygen administration. METHODS. A population-based study evaluated data from 4 Swedish perinatal level III centers during the period of 1998 to 2003. During this period, the centers used either of 2 resuscitation strategies (initial oxygen administration of 40% or 100%). Live-born, singleton, term infants with 1-minute Apgar scores of < 4, with a birth weight appropriate for gestational age, and without major malformations were included in the study (n = 1223). RESULTS. Infants born in hospitals using a... (More)
- OBJECTIVES. The aim of this study was to evaluate whether a resuscitation strategy based on administration of 40% oxygen influences mortality rates and rates of improvement in 5-minute Apgar scores, compared with a strategy based on 100% oxygen administration. METHODS. A population-based study evaluated data from 4 Swedish perinatal level III centers during the period of 1998 to 2003. During this period, the centers used either of 2 resuscitation strategies (initial oxygen administration of 40% or 100%). Live-born, singleton, term infants with 1-minute Apgar scores of < 4, with a birth weight appropriate for gestational age, and without major malformations were included in the study (n = 1223). RESULTS. Infants born in hospitals using a 40% oxygen strategy had a more rapid Apgar score increase than did infants born in hospitals using a 100% oxygen strategy; however, no difference remained at 10 minutes. The mean Apgar score increased from 2.01 at 1 minute to 6.74 at 5 minutes in the 2 hospitals initiating resuscitation with 40% oxygen, compared with 2.01 to 6.38 in the 2 hospitals using 100% oxygen, with a mean difference in Apgar score increases of 0.36. At 5 minutes, 44.3% of infants born in the hospitals using 100% oxygen had an Apgar score of < 7, compared with 34.0% of infants at the hospitals using 40% oxygen. At 10 minutes, the mean Apgar scores were 8.16 at the hospitals using 40% oxygen and 8.07 at the hospitals using 100% oxygen. There were no significant differences in rates of neonatal death, hypoxic ischemic encephalopathy, or seizures in relation to the 2 oxygen strategies. CONCLUSION. Severely depressed term infants born in hospitals initiating resuscitation with 40% oxygen had earlier Apgar score recovery than did infants born in hospitals using a 100% oxygen strategy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/164198
- author
- Hellström-Westas, Lena LU ; Forsblad, Kristina ; Sjors, Gunnar ; Saugstad, Ola Didrik ; Björklund, Lars LU ; Marsal, Karel LU and Källén, Karin LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Resuscitation: methods, Registries, Newborn, Infant, Humans, Apgar Score, Oxygen: administration & dosage, Diseases: therapy, Severity of Illness Index, Sweden, Time Factors
- in
- Pediatrics
- volume
- 118
- issue
- 6
- pages
- 1798 - 1804
- publisher
- American Academy of Pediatrics
- external identifiers
-
- wos:000242478900076
- scopus:33947149592
- pmid:17142501
- ISSN
- 1098-4275
- DOI
- 10.1542/peds.2006-0102
- language
- English
- LU publication?
- yes
- id
- 477eb812-4345-4555-8983-3ea5cadeba74 (old id 164198)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17142501&dopt=Abstract
- date added to LUP
- 2016-04-01 16:23:33
- date last changed
- 2022-01-28 19:23:12
@article{477eb812-4345-4555-8983-3ea5cadeba74,
abstract = {{OBJECTIVES. The aim of this study was to evaluate whether a resuscitation strategy based on administration of 40% oxygen influences mortality rates and rates of improvement in 5-minute Apgar scores, compared with a strategy based on 100% oxygen administration. METHODS. A population-based study evaluated data from 4 Swedish perinatal level III centers during the period of 1998 to 2003. During this period, the centers used either of 2 resuscitation strategies (initial oxygen administration of 40% or 100%). Live-born, singleton, term infants with 1-minute Apgar scores of < 4, with a birth weight appropriate for gestational age, and without major malformations were included in the study (n = 1223). RESULTS. Infants born in hospitals using a 40% oxygen strategy had a more rapid Apgar score increase than did infants born in hospitals using a 100% oxygen strategy; however, no difference remained at 10 minutes. The mean Apgar score increased from 2.01 at 1 minute to 6.74 at 5 minutes in the 2 hospitals initiating resuscitation with 40% oxygen, compared with 2.01 to 6.38 in the 2 hospitals using 100% oxygen, with a mean difference in Apgar score increases of 0.36. At 5 minutes, 44.3% of infants born in the hospitals using 100% oxygen had an Apgar score of < 7, compared with 34.0% of infants at the hospitals using 40% oxygen. At 10 minutes, the mean Apgar scores were 8.16 at the hospitals using 40% oxygen and 8.07 at the hospitals using 100% oxygen. There were no significant differences in rates of neonatal death, hypoxic ischemic encephalopathy, or seizures in relation to the 2 oxygen strategies. CONCLUSION. Severely depressed term infants born in hospitals initiating resuscitation with 40% oxygen had earlier Apgar score recovery than did infants born in hospitals using a 100% oxygen strategy.}},
author = {{Hellström-Westas, Lena and Forsblad, Kristina and Sjors, Gunnar and Saugstad, Ola Didrik and Björklund, Lars and Marsal, Karel and Källén, Karin}},
issn = {{1098-4275}},
keywords = {{Resuscitation: methods; Registries; Newborn; Infant; Humans; Apgar Score; Oxygen: administration & dosage; Diseases: therapy; Severity of Illness Index; Sweden; Time Factors}},
language = {{eng}},
number = {{6}},
pages = {{1798--1804}},
publisher = {{American Academy of Pediatrics}},
series = {{Pediatrics}},
title = {{Earlier Apgar score increase in severely depressed term infants cared for in Swedish level III units with 40% oxygen versus 100% oxygen resuscitation strategies: a population-based register study.}},
url = {{http://dx.doi.org/10.1542/peds.2006-0102}},
doi = {{10.1542/peds.2006-0102}},
volume = {{118}},
year = {{2006}},
}