Advanced

Cerebral perfusion information obtained by dynamic contrast-enhanced phase-shift magnetic resonance imaging: comparison with model-free arterial spin labelling.

Wirestam, Ronnie LU ; Lind, Emelie; van Westen, Danielle LU ; Markenroth Bloch, Karin LU ; Ståhlberg, Freddy LU and Knutsson, Linda LU (2010) In Clinical Physiology and Functional Imaging2002-01-01+01:00 30(5). p.375-379
Abstract
Summary Phase-shift time curves following a bolus injection of gadolinium contrast agent were registered for grey-matter regions and large vessels in 14 subjects. Deconvolving a tissue phase-shift curve with a phase-based arterial input function resulted in a tissue residue function R(t). The peak value of R(t) provided a relative cerebral blood flow (CBF) index, while the area-to-height ratio of R(t) provided quantitative mean transit time (MTT). For comparison, quantitative CBF values in grey matter were acquired using model-free arterial spin labelling (ASL). The phase-based relative CBF estimates showed good linear correlation with ASL-based CBF (r = 0.82). Grey-matter MTT was 4.9 +/- 1.1 s (mean +/- SD).
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Physiology and Functional Imaging2002-01-01+01:00
volume
30
issue
5
pages
375 - 379
publisher
Wiley Online Library
external identifiers
  • wos:000280630600012
  • pmid:20618360
  • scopus:77955815940
ISSN
1475-0961
DOI
10.1111/j.1475-097X.2010.00947.x
language
English
LU publication?
yes
id
e501f7ca-9693-4bcb-9763-507309e3ed75 (old id 1645132)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20618360?dopt=Abstract
date added to LUP
2010-08-02 11:22:01
date last changed
2018-05-29 11:33:08
@article{e501f7ca-9693-4bcb-9763-507309e3ed75,
  abstract     = {Summary Phase-shift time curves following a bolus injection of gadolinium contrast agent were registered for grey-matter regions and large vessels in 14 subjects. Deconvolving a tissue phase-shift curve with a phase-based arterial input function resulted in a tissue residue function R(t). The peak value of R(t) provided a relative cerebral blood flow (CBF) index, while the area-to-height ratio of R(t) provided quantitative mean transit time (MTT). For comparison, quantitative CBF values in grey matter were acquired using model-free arterial spin labelling (ASL). The phase-based relative CBF estimates showed good linear correlation with ASL-based CBF (r = 0.82). Grey-matter MTT was 4.9 +/- 1.1 s (mean +/- SD).},
  author       = {Wirestam, Ronnie and Lind, Emelie and van Westen, Danielle and Markenroth Bloch, Karin and Ståhlberg, Freddy and Knutsson, Linda},
  issn         = {1475-0961},
  language     = {eng},
  number       = {5},
  pages        = {375--379},
  publisher    = {Wiley Online Library},
  series       = {Clinical Physiology and Functional Imaging2002-01-01+01:00},
  title        = {Cerebral perfusion information obtained by dynamic contrast-enhanced phase-shift magnetic resonance imaging: comparison with model-free arterial spin labelling.},
  url          = {http://dx.doi.org/10.1111/j.1475-097X.2010.00947.x},
  volume       = {30},
  year         = {2010},
}