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Estimation of the Age-Dependent Decline of Glomerular Filtration Rate from Formulas Based on Creatinine and Cystatin C in the General Elderly Population.

Christensson, Anders LU and Elmståhl, Sölve LU (2011) In Nephron Clinical Practice 117(1). p.40-50
Abstract
Background/Aims: To evaluate the performance of estimation formulas for glomerular filtration rate (GFR) based on creatinine and cystatin C in elderly. Methods: This study includes 2,931 men and women comprising nine age cohorts (60-93 years) from a longitudinal population-based project in Sweden. The participants were divided into four age groups. GFR was estimated from four formulas: the Modification of Diet in Renal Disease (MDRD), CKD-EPI and Cockroft-Gault (CG) based on creatinine and one based on cystatin C (eGFR-CysC). CG was also adjusted for body surface area (BSA) to CG/BSA. Results: CG, CG/BSA and eGFR-CysC yielded significantly lower GFR values compared to MDRD and CKD-EPI in the oldest persons (>80 years). A low GFR (<30... (More)
Background/Aims: To evaluate the performance of estimation formulas for glomerular filtration rate (GFR) based on creatinine and cystatin C in elderly. Methods: This study includes 2,931 men and women comprising nine age cohorts (60-93 years) from a longitudinal population-based project in Sweden. The participants were divided into four age groups. GFR was estimated from four formulas: the Modification of Diet in Renal Disease (MDRD), CKD-EPI and Cockroft-Gault (CG) based on creatinine and one based on cystatin C (eGFR-CysC). CG was also adjusted for body surface area (BSA) to CG/BSA. Results: CG, CG/BSA and eGFR-CysC yielded significantly lower GFR values compared to MDRD and CKD-EPI in the oldest persons (>80 years). A low GFR (<30 ml/min/1.73 m(2)) was demonstrated with MDRD in 3.3% (80-89 years) and in 6.3% (>90 years). With CG/BSA it was 8.0% (80-89 years) and 27.2% (>90 years), and with eGFR-CysC it was 12.1% (80-89 years) and 27% (>90 years), respectively. The individual formulas showed different eGFR in the four age cohorts and also different slopes by increasing age. CG/BSA and eGFR-CysC both show steeper declines than MDRD and CKD-EPI. Conclusion: Age-associated decline of renal function is common in elderly and increases immensely after the age of 80 years. More than 25% of the oldest demonstrate eGFR <30 ml/min/1.73 m(2). CG and eGFR-CysC yielded the highest prevalence of decline and MDRD the lowest. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nephron Clinical Practice
volume
117
issue
1
pages
40 - 50
publisher
Karger
external identifiers
  • wos:000280683300009
  • pmid:20689324
  • scopus:77955122884
ISSN
1660-2110
DOI
10.1159/000319646
language
English
LU publication?
yes
id
91770abb-ca46-4203-a4c1-0c02a415a601 (old id 1665515)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20689324?dopt=Abstract
date added to LUP
2010-09-02 10:49:01
date last changed
2017-09-17 08:18:48
@article{91770abb-ca46-4203-a4c1-0c02a415a601,
  abstract     = {Background/Aims: To evaluate the performance of estimation formulas for glomerular filtration rate (GFR) based on creatinine and cystatin C in elderly. Methods: This study includes 2,931 men and women comprising nine age cohorts (60-93 years) from a longitudinal population-based project in Sweden. The participants were divided into four age groups. GFR was estimated from four formulas: the Modification of Diet in Renal Disease (MDRD), CKD-EPI and Cockroft-Gault (CG) based on creatinine and one based on cystatin C (eGFR-CysC). CG was also adjusted for body surface area (BSA) to CG/BSA. Results: CG, CG/BSA and eGFR-CysC yielded significantly lower GFR values compared to MDRD and CKD-EPI in the oldest persons (&gt;80 years). A low GFR (&lt;30 ml/min/1.73 m(2)) was demonstrated with MDRD in 3.3% (80-89 years) and in 6.3% (&gt;90 years). With CG/BSA it was 8.0% (80-89 years) and 27.2% (&gt;90 years), and with eGFR-CysC it was 12.1% (80-89 years) and 27% (&gt;90 years), respectively. The individual formulas showed different eGFR in the four age cohorts and also different slopes by increasing age. CG/BSA and eGFR-CysC both show steeper declines than MDRD and CKD-EPI. Conclusion: Age-associated decline of renal function is common in elderly and increases immensely after the age of 80 years. More than 25% of the oldest demonstrate eGFR &lt;30 ml/min/1.73 m(2). CG and eGFR-CysC yielded the highest prevalence of decline and MDRD the lowest.},
  author       = {Christensson, Anders and Elmståhl, Sölve},
  issn         = {1660-2110},
  language     = {eng},
  number       = {1},
  pages        = {40--50},
  publisher    = {Karger},
  series       = {Nephron Clinical Practice},
  title        = {Estimation of the Age-Dependent Decline of Glomerular Filtration Rate from Formulas Based on Creatinine and Cystatin C in the General Elderly Population.},
  url          = {http://dx.doi.org/10.1159/000319646},
  volume       = {117},
  year         = {2011},
}