Genetically determined mannan-binding lectin deficiency is of minor importance in determining susceptibility to severe infections and vascular organ damage in systemic lupus erythematosus.
(2007) In Lupus 16(4). p.245-253- Abstract
- Deficiency of mannan-binding lectin (MBL) has been reported to impact susceptibility to severe nfections and atherosclerosis in systemic lupus erythematosus (SLE). In this study, MBL gene polymorphisms were analysed in 143 SLE patients and the frequency of severe infections and organ damage according to SLICC/ACR Damage Index regarding cerebrovascular accidents, angina pectoris, coronary by-pass surgery, myocardial infarction and peripheral arterial disease leading to significant tissue loss, were recorded during a mean follow-up time of 15 years from diagnosis. In a multiple logistic regression model, smoking (P = 0.001), hypertension (P = 0.030), alcohol intake (P = 0.027) and higher triglyceride concentration (P = 0.026) were associated... (More)
- Deficiency of mannan-binding lectin (MBL) has been reported to impact susceptibility to severe nfections and atherosclerosis in systemic lupus erythematosus (SLE). In this study, MBL gene polymorphisms were analysed in 143 SLE patients and the frequency of severe infections and organ damage according to SLICC/ACR Damage Index regarding cerebrovascular accidents, angina pectoris, coronary by-pass surgery, myocardial infarction and peripheral arterial disease leading to significant tissue loss, were recorded during a mean follow-up time of 15 years from diagnosis. In a multiple logistic regression model, smoking (P = 0.001), hypertension (P = 0.030), alcohol intake (P = 0.027) and higher triglyceride concentration (P = 0.026) were associated with cerebrovascular, cardiovascular and peripheral arterial organ damage (CPAD), while the association with MBL deficiency did not reach significance (P = 0.098). Alcohol intake (> 15 g/month) was inversely correlated with CPAD (OR = 0.29, 95%Cl 0.096-0.87). MBL deficiency was not significantly more common in SLE patients with severe infections in a multivariate analysis (P > 0.3). In conclusion, classical risk factors such as smoking, hypertension, low alcohol intake and elevated triglyceride concentration were relatively more important for development of CPAD than MBL deficiency in SLE. Furthermore, MBL deficiency did not contribute to development of major infections in SLE. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/167558
- author
- Jönsen, Andreas LU ; Gullstrand, Birgitta LU ; Guner, N ; Bengtsson, Anders LU ; Nived, Ola LU ; Truedsson, Lennart LU and Sturfelt, Gunnar LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- atherosclerosis, mannan-binding lectin, SLICC-DI, systemic, lupus erythematosus, infection
- in
- Lupus
- volume
- 16
- issue
- 4
- pages
- 245 - 253
- publisher
- SAGE Publications
- external identifiers
-
- wos:000246669200002
- scopus:34249110312
- pmid:17439930
- ISSN
- 0961-2033
- DOI
- 10.1177/09612033070160040201
- language
- English
- LU publication?
- yes
- id
- 2d6bbbc0-5e93-4173-ba41-d57c2f3c11aa (old id 167558)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17439930&dopt=Abstract
- date added to LUP
- 2016-04-01 11:49:40
- date last changed
- 2022-01-26 18:52:22
@article{2d6bbbc0-5e93-4173-ba41-d57c2f3c11aa,
abstract = {{Deficiency of mannan-binding lectin (MBL) has been reported to impact susceptibility to severe nfections and atherosclerosis in systemic lupus erythematosus (SLE). In this study, MBL gene polymorphisms were analysed in 143 SLE patients and the frequency of severe infections and organ damage according to SLICC/ACR Damage Index regarding cerebrovascular accidents, angina pectoris, coronary by-pass surgery, myocardial infarction and peripheral arterial disease leading to significant tissue loss, were recorded during a mean follow-up time of 15 years from diagnosis. In a multiple logistic regression model, smoking (P = 0.001), hypertension (P = 0.030), alcohol intake (P = 0.027) and higher triglyceride concentration (P = 0.026) were associated with cerebrovascular, cardiovascular and peripheral arterial organ damage (CPAD), while the association with MBL deficiency did not reach significance (P = 0.098). Alcohol intake (> 15 g/month) was inversely correlated with CPAD (OR = 0.29, 95%Cl 0.096-0.87). MBL deficiency was not significantly more common in SLE patients with severe infections in a multivariate analysis (P > 0.3). In conclusion, classical risk factors such as smoking, hypertension, low alcohol intake and elevated triglyceride concentration were relatively more important for development of CPAD than MBL deficiency in SLE. Furthermore, MBL deficiency did not contribute to development of major infections in SLE.}},
author = {{Jönsen, Andreas and Gullstrand, Birgitta and Guner, N and Bengtsson, Anders and Nived, Ola and Truedsson, Lennart and Sturfelt, Gunnar}},
issn = {{0961-2033}},
keywords = {{atherosclerosis; mannan-binding lectin; SLICC-DI; systemic; lupus erythematosus; infection}},
language = {{eng}},
number = {{4}},
pages = {{245--253}},
publisher = {{SAGE Publications}},
series = {{Lupus}},
title = {{Genetically determined mannan-binding lectin deficiency is of minor importance in determining susceptibility to severe infections and vascular organ damage in systemic lupus erythematosus.}},
url = {{http://dx.doi.org/10.1177/09612033070160040201}},
doi = {{10.1177/09612033070160040201}},
volume = {{16}},
year = {{2007}},
}