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Hypoxia inducible factor-2alpha in cancer.

Löfstedt, Tobias LU ; Fredlund, Erik LU ; Holmquist Mengelbier, Linda LU ; Pietras, Alexander LU ; Ovenberger, Marie LU ; Poellinger, Lorenz and Påhlman, Sven LU (2007) In Cell Cycle 6(8). p.919-926
Abstract
Poorly oxygenated ( hypoxic) tumors are frequently more aggressive compared to corresponding tumors that are better oxygenated. Adaptation to hypoxia is primarily mediated by two closely related hypoxia inducible transcription factor complexes, HIF-1 and HIF-2, which become stabilized and activated at low oxygen levels. Whether HIF-1 and HIF-2 have different roles in tumorigenesis is an open question and an issue we discuss. With focus on HIF-2, we summarize reported phenotypical changes of HIF genetic models and HIF expression patterns during normal development, in adult non - malignant tissues and in tumors. We further address the much - discussed subject of target gene preferences between HIF-1 and HIF-2, given that both transcription... (More)
Poorly oxygenated ( hypoxic) tumors are frequently more aggressive compared to corresponding tumors that are better oxygenated. Adaptation to hypoxia is primarily mediated by two closely related hypoxia inducible transcription factor complexes, HIF-1 and HIF-2, which become stabilized and activated at low oxygen levels. Whether HIF-1 and HIF-2 have different roles in tumorigenesis is an open question and an issue we discuss. With focus on HIF-2, we summarize reported phenotypical changes of HIF genetic models and HIF expression patterns during normal development, in adult non - malignant tissues and in tumors. We further address the much - discussed subject of target gene preferences between HIF-1 and HIF-2, given that both transcription factors bind to the same DNA motif. Finally, we also discuss the observations that the oxygen - sensitive HIF-2 alpha subunit is accumulated and active under non - hypoxic conditions as exemplified by HIF-2 alpha expressing tumor macrophages and neuroblastoma cells located in seemingly well - vascularized tumor regions and how this phenomenon is related to tumor aggressiveness. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
target genes, neuroblastoma, regulation, development, adaptation, hypoxia, cancer, hypoxia-inducible factor
in
Cell Cycle
volume
6
issue
8
pages
919 - 926
publisher
Landes Bioscience
external identifiers
  • wos:000245948300010
ISSN
1551-4005
language
English
LU publication?
yes
id
4c854fdb-f32f-4633-b235-9fcb54aca5e2 (old id 167829)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17404509&dopt=Abstract
http://www.landesbioscience.com/journals/cc/article/4133
date added to LUP
2007-07-25 16:13:24
date last changed
2016-04-15 19:38:56
@article{4c854fdb-f32f-4633-b235-9fcb54aca5e2,
  abstract     = {Poorly oxygenated ( hypoxic) tumors are frequently more aggressive compared to corresponding tumors that are better oxygenated. Adaptation to hypoxia is primarily mediated by two closely related hypoxia inducible transcription factor complexes, HIF-1 and HIF-2, which become stabilized and activated at low oxygen levels. Whether HIF-1 and HIF-2 have different roles in tumorigenesis is an open question and an issue we discuss. With focus on HIF-2, we summarize reported phenotypical changes of HIF genetic models and HIF expression patterns during normal development, in adult non - malignant tissues and in tumors. We further address the much - discussed subject of target gene preferences between HIF-1 and HIF-2, given that both transcription factors bind to the same DNA motif. Finally, we also discuss the observations that the oxygen - sensitive HIF-2 alpha subunit is accumulated and active under non - hypoxic conditions as exemplified by HIF-2 alpha expressing tumor macrophages and neuroblastoma cells located in seemingly well - vascularized tumor regions and how this phenomenon is related to tumor aggressiveness.},
  author       = {Löfstedt, Tobias and Fredlund, Erik and Holmquist Mengelbier, Linda and Pietras, Alexander and Ovenberger, Marie and Poellinger, Lorenz and Påhlman, Sven},
  issn         = {1551-4005},
  keyword      = {target genes,neuroblastoma,regulation,development,adaptation,hypoxia,cancer,hypoxia-inducible factor},
  language     = {eng},
  number       = {8},
  pages        = {919--926},
  publisher    = {Landes Bioscience},
  series       = {Cell Cycle},
  title        = {Hypoxia inducible factor-2alpha in cancer.},
  volume       = {6},
  year         = {2007},
}