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Absence of the common IGF1 19 CA-repeat allele is more common among BRCA1 mutation carriers than among non-carriers from BRCA1 families.

Henningson, Maria; Bågeman, Erika LU ; Törngren, Therese LU ; Borg, Åke LU ; Olsson, Håkan LU and Jernström, Helena LU (2007) In Familial Cancer 6(4). p.445-452
Abstract
BRCA1 mutations predispose to early-onset breast cancer. We previously reported an association between absence of the common IGF1 19 CA-repeat allele (IGF1-19/-19) and being a BRCA1 mutation carrier in young women from breast cancer high-risk families. Others have reported a four-fold risk of premenopausal breast cancer in women with a family history and the IGF1-19/-19 genotype. The aim of this study was to investigate whether the IGF1-19/-19 genotype was associated with being a BRCA1 mutation carrier among women from BRCA1 families. DNA was available from 268 women with known BRCA1 status from the South Swedish Health Care Region. IGF1 genotyping was successfully performed with fragment analysis in 211 women from 96 families. The... (More)
BRCA1 mutations predispose to early-onset breast cancer. We previously reported an association between absence of the common IGF1 19 CA-repeat allele (IGF1-19/-19) and being a BRCA1 mutation carrier in young women from breast cancer high-risk families. Others have reported a four-fold risk of premenopausal breast cancer in women with a family history and the IGF1-19/-19 genotype. The aim of this study was to investigate whether the IGF1-19/-19 genotype was associated with being a BRCA1 mutation carrier among women from BRCA1 families. DNA was available from 268 women with known BRCA1 status from the South Swedish Health Care Region. IGF1 genotyping was successfully performed with fragment analysis in 211 women from 96 families. The IGF1-19/-19 genotype was significantly more common among BRCA1 mutation carriers (14.2%) than among non-carriers (4.8%), OR 3.3 (95%CI 1.11-9.78, P = 0.03) adjusted for family clustering. We confirmed our previous finding of an association between the IGF1-19/-19 genotype and BRCA1 mutation status. Since the IGF1-19/-19 genotype in combination with OC use or multiparity confers an increased risk for early onset breast cancer in high-risk women and in women from the general population, future studies are needed to elucidate the importance of the IGF1-19/-19 genotype concerning the variability in breast cancer risk among BRCA1 mutation carriers. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
oral contraceptive, genotype, BRCA1, breast cancer, parity, IGF1
in
Familial Cancer
volume
6
issue
4
pages
445 - 452
publisher
Kluwer
external identifiers
  • wos:000250302300003
  • scopus:35448948734
ISSN
1389-9600
DOI
10.1007/s10689-007-9141-0
language
English
LU publication?
yes
id
8ecc723e-110e-4155-91aa-9ba8dbb22f6e (old id 168390)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17484040&dopt=Abstract
date added to LUP
2007-07-23 11:07:17
date last changed
2017-01-01 04:53:51
@article{8ecc723e-110e-4155-91aa-9ba8dbb22f6e,
  abstract     = {BRCA1 mutations predispose to early-onset breast cancer. We previously reported an association between absence of the common IGF1 19 CA-repeat allele (IGF1-19/-19) and being a BRCA1 mutation carrier in young women from breast cancer high-risk families. Others have reported a four-fold risk of premenopausal breast cancer in women with a family history and the IGF1-19/-19 genotype. The aim of this study was to investigate whether the IGF1-19/-19 genotype was associated with being a BRCA1 mutation carrier among women from BRCA1 families. DNA was available from 268 women with known BRCA1 status from the South Swedish Health Care Region. IGF1 genotyping was successfully performed with fragment analysis in 211 women from 96 families. The IGF1-19/-19 genotype was significantly more common among BRCA1 mutation carriers (14.2%) than among non-carriers (4.8%), OR 3.3 (95%CI 1.11-9.78, P = 0.03) adjusted for family clustering. We confirmed our previous finding of an association between the IGF1-19/-19 genotype and BRCA1 mutation status. Since the IGF1-19/-19 genotype in combination with OC use or multiparity confers an increased risk for early onset breast cancer in high-risk women and in women from the general population, future studies are needed to elucidate the importance of the IGF1-19/-19 genotype concerning the variability in breast cancer risk among BRCA1 mutation carriers.},
  author       = {Henningson, Maria and Bågeman, Erika and Törngren, Therese and Borg, Åke and Olsson, Håkan and Jernström, Helena},
  issn         = {1389-9600},
  keyword      = {oral contraceptive,genotype,BRCA1,breast cancer,parity,IGF1},
  language     = {eng},
  number       = {4},
  pages        = {445--452},
  publisher    = {Kluwer},
  series       = {Familial Cancer},
  title        = {Absence of the common IGF1 19 CA-repeat allele is more common among BRCA1 mutation carriers than among non-carriers from BRCA1 families.},
  url          = {http://dx.doi.org/10.1007/s10689-007-9141-0},
  volume       = {6},
  year         = {2007},
}