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A Cereal-Based Evening Meal Rich in Indigestible Carbohydrates Increases Plasma Butyrate the Next Morning.

Nilsson, Anne LU ; Östman, Elin LU ; Knudsen, Knud E B; Holst, Jens J and Björck, Inger LU (2010) In Journal of Nutrition 140. p.1932-1936
Abstract
Epidemiological studies have shown an inverse relation between a whole grain consumption and risk of type-2 diabetes and cardiovascular disease. One tentative mechanism relates to colonic metabolism of indigestible carbohydrates. In a previous study, we reported a positive relation between colonic fermentation and improved glucose tolerance. This work can be seen as an extension of that study, focusing on the tentative role of specific colonic metabolites, i.e. SCFA. Plasma concentrations of acetate, propionate, and butyrate were determined in the morning in healthy participants (5 women and 10 men, mean +/- SD: 25.9 +/- 3.2 y, BMI < 25) following 8 different cereal-based evening meals (50 g available starch) varying in content of... (More)
Epidemiological studies have shown an inverse relation between a whole grain consumption and risk of type-2 diabetes and cardiovascular disease. One tentative mechanism relates to colonic metabolism of indigestible carbohydrates. In a previous study, we reported a positive relation between colonic fermentation and improved glucose tolerance. This work can be seen as an extension of that study, focusing on the tentative role of specific colonic metabolites, i.e. SCFA. Plasma concentrations of acetate, propionate, and butyrate were determined in the morning in healthy participants (5 women and 10 men, mean +/- SD: 25.9 +/- 3.2 y, BMI < 25) following 8 different cereal-based evening meals (50 g available starch) varying in content of indigestible carbohydrates. Each participant consumed all test meals in a random order on separate evenings. At a standardized breakfast following evening test meals, the postprandial glucose response (incremental area under the curve, 0-120 min) was inversely related to plasma butyrate (r = -0.26; P < 0.01) and acetate (r = -0.20; P < 0.05) concentrations. Evening meals composed of high-amylose barley kernels or high-beta-glucan barley kernels resulted in higher plasma butyrate concentrations the following morning compared with an evening meal with white wheat bread (P < 0.05). The results support the view that cereal products rich in indigestible carbohydrates may improve glucose tolerance through a mechanism involving colonic fermentation and generation of SCFA, where in particular butyric acid may be involved. This mechanism may be one explanation by which whole grain is protective against type 2 diabetes and cardiovascular disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Nutrition
volume
140
pages
1932 - 1936
publisher
American Society for Nutrition
external identifiers
  • wos:000283525700005
  • pmid:20810606
  • scopus:78149262117
ISSN
1541-6100
DOI
10.3945/jn.110.123604
language
English
LU publication?
yes
id
53b55626-f8ff-46da-a615-979142491ddb (old id 1688609)
date added to LUP
2010-10-22 12:25:26
date last changed
2018-07-15 03:01:51
@article{53b55626-f8ff-46da-a615-979142491ddb,
  abstract     = {Epidemiological studies have shown an inverse relation between a whole grain consumption and risk of type-2 diabetes and cardiovascular disease. One tentative mechanism relates to colonic metabolism of indigestible carbohydrates. In a previous study, we reported a positive relation between colonic fermentation and improved glucose tolerance. This work can be seen as an extension of that study, focusing on the tentative role of specific colonic metabolites, i.e. SCFA. Plasma concentrations of acetate, propionate, and butyrate were determined in the morning in healthy participants (5 women and 10 men, mean +/- SD: 25.9 +/- 3.2 y, BMI &lt; 25) following 8 different cereal-based evening meals (50 g available starch) varying in content of indigestible carbohydrates. Each participant consumed all test meals in a random order on separate evenings. At a standardized breakfast following evening test meals, the postprandial glucose response (incremental area under the curve, 0-120 min) was inversely related to plasma butyrate (r = -0.26; P &lt; 0.01) and acetate (r = -0.20; P &lt; 0.05) concentrations. Evening meals composed of high-amylose barley kernels or high-beta-glucan barley kernels resulted in higher plasma butyrate concentrations the following morning compared with an evening meal with white wheat bread (P &lt; 0.05). The results support the view that cereal products rich in indigestible carbohydrates may improve glucose tolerance through a mechanism involving colonic fermentation and generation of SCFA, where in particular butyric acid may be involved. This mechanism may be one explanation by which whole grain is protective against type 2 diabetes and cardiovascular disease.},
  author       = {Nilsson, Anne and Östman, Elin and Knudsen, Knud E B and Holst, Jens J and Björck, Inger},
  issn         = {1541-6100},
  language     = {eng},
  pages        = {1932--1936},
  publisher    = {American Society for Nutrition},
  series       = {Journal of Nutrition},
  title        = {A Cereal-Based Evening Meal Rich in Indigestible Carbohydrates Increases Plasma Butyrate the Next Morning.},
  url          = {http://dx.doi.org/10.3945/jn.110.123604},
  volume       = {140},
  year         = {2010},
}