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Association between fat intake, physical activity and mortality depending on genetic variation in FTO.

Sonestedt, Emily LU ; Gullberg, Bo LU ; Ericson, Ulrika LU ; Wirfält, Elisabet LU ; Hedblad, Bo LU and Orho-Melander, Marju LU (2011) In International Journal of Obesity 35. p.1041-1049
Abstract
Objective:We wanted to explore if FTO genotype interacts with fat intake, or leisure-time physical activity, on fat mass, lean mass and mortality.Subjects and methods:Among 22 799 individuals (44-74 years) in the population-based Malmö diet and cancer cohort that were genotyped for rs9939609 in FTO and had information on dietary intake (from a modified diet history method) and no history of diabetes, cancer or cardiovascular disease, 2255 deaths (including 1100 cancer and 674 cardiovascular deaths) occurred during 12.0 years of follow-up. Leisure-time physical activity was determined from a list of 17 different physical activities in a questionnaire. Body composition was measured using bioelectric impedance method.Results:FTO genotype... (More)
Objective:We wanted to explore if FTO genotype interacts with fat intake, or leisure-time physical activity, on fat mass, lean mass and mortality.Subjects and methods:Among 22 799 individuals (44-74 years) in the population-based Malmö diet and cancer cohort that were genotyped for rs9939609 in FTO and had information on dietary intake (from a modified diet history method) and no history of diabetes, cancer or cardiovascular disease, 2255 deaths (including 1100 cancer and 674 cardiovascular deaths) occurred during 12.0 years of follow-up. Leisure-time physical activity was determined from a list of 17 different physical activities in a questionnaire. Body composition was measured using bioelectric impedance method.Results:FTO genotype associated strongly with both fat mass and lean mass (P(trend)<1 × 10(-16) for both) but we found only significant interactions with fat intake, or physical activity, on fat mass (P(interaction)=0.01 and 0.004). No significant interaction between FTO genotype and fat intake (P(interaction)=0.72), or leisure-time physical activity (P(interaction)=0.07), on total mortality were observed. However, we observed a significant interaction between leisure-time physical activity and FTO genotype on cardiovascular mortality (P(interaction)=0.03). The highest vs lowest quintile of physical activity was associated with 46% (95% confidence interval, 17-64%) reduced cardiovascular mortality among TT-carriers (P(trend)=0.004), and 11% reduced cardiovascular mortality among A-allele carriers (P(trend)=0.68).Conclusion:Our results indicate that FTO genotype associates with both fat mass and lean mass, but the level of fat intake and physical activity only modify the association with fat mass. In addition, FTO genotype may modify the association between physical activity and cardiovascular mortality.International Journal of Obesity advance online publication, 21 December 2010; doi:10.1038/ijo.2010.263. (Less)
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Contribution to journal
publication status
published
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in
International Journal of Obesity
volume
35
pages
1041 - 1049
publisher
Nature Publishing Group
external identifiers
  • wos:000293784100004
  • pmid:21179003
  • scopus:80051594894
ISSN
1476-5497
DOI
10.1038/ijo.2010.263
language
English
LU publication?
yes
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c96e86b2-fb91-4a3b-a162-3add15b44cbb (old id 1755860)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21179003?dopt=Abstract
date added to LUP
2011-01-03 18:19:02
date last changed
2017-09-03 04:46:56
@article{c96e86b2-fb91-4a3b-a162-3add15b44cbb,
  abstract     = {Objective:We wanted to explore if FTO genotype interacts with fat intake, or leisure-time physical activity, on fat mass, lean mass and mortality.Subjects and methods:Among 22 799 individuals (44-74 years) in the population-based Malmö diet and cancer cohort that were genotyped for rs9939609 in FTO and had information on dietary intake (from a modified diet history method) and no history of diabetes, cancer or cardiovascular disease, 2255 deaths (including 1100 cancer and 674 cardiovascular deaths) occurred during 12.0 years of follow-up. Leisure-time physical activity was determined from a list of 17 different physical activities in a questionnaire. Body composition was measured using bioelectric impedance method.Results:FTO genotype associated strongly with both fat mass and lean mass (P(trend)&lt;1 × 10(-16) for both) but we found only significant interactions with fat intake, or physical activity, on fat mass (P(interaction)=0.01 and 0.004). No significant interaction between FTO genotype and fat intake (P(interaction)=0.72), or leisure-time physical activity (P(interaction)=0.07), on total mortality were observed. However, we observed a significant interaction between leisure-time physical activity and FTO genotype on cardiovascular mortality (P(interaction)=0.03). The highest vs lowest quintile of physical activity was associated with 46% (95% confidence interval, 17-64%) reduced cardiovascular mortality among TT-carriers (P(trend)=0.004), and 11% reduced cardiovascular mortality among A-allele carriers (P(trend)=0.68).Conclusion:Our results indicate that FTO genotype associates with both fat mass and lean mass, but the level of fat intake and physical activity only modify the association with fat mass. In addition, FTO genotype may modify the association between physical activity and cardiovascular mortality.International Journal of Obesity advance online publication, 21 December 2010; doi:10.1038/ijo.2010.263.},
  author       = {Sonestedt, Emily and Gullberg, Bo and Ericson, Ulrika and Wirfält, Elisabet and Hedblad, Bo and Orho-Melander, Marju},
  issn         = {1476-5497},
  language     = {eng},
  pages        = {1041--1049},
  publisher    = {Nature Publishing Group},
  series       = {International Journal of Obesity},
  title        = {Association between fat intake, physical activity and mortality depending on genetic variation in FTO.},
  url          = {http://dx.doi.org/10.1038/ijo.2010.263},
  volume       = {35},
  year         = {2011},
}